Abstract:
OBJECTIVES:To assess the clinical value of retinal or choroidal biopsy in establishing a definitive diagnosis directing subsequent management and to assess the risk involved in such surgery. DESIGN:Retrospective noncomparative interventional case series. PARTICIPANTS:Thirteen patients with uveitis of suspected malignant or infectious origin. One patient had 2 consecutive biopsies on the same eye. METHODS:A retrospective review of a 4-year period was undertaken of all those cases in which the biopsy was taken for diagnostic purposes at a single institution. MAIN OUTCOME MEASURES:Ability of biopsy to establish a pathologic diagnosis and guide treatment and surgical complications. RESULTS:A transscleral approach was used in 4 and a pars plana vitrectomy approach in 10 of the biopsies. The only operative complication was a retinal break in 1 case. Postoperative events that might be related to the surgery included 1 localized retinal detachment, 2 cataracts, and 1 phthisical eye. The pathologic diagnosis differed from the initial clinical diagnosis in 5 of the 13 cases. The biopsy result directed specific appropriate treatment in 7 of the 13 cases. In the 6 remaining cases, no specific diagnosis was confirmed, but the results of the biopsy were useful in excluding malignancy and in some cases allowing a therapeutic trial. CONCLUSIONS:Retinal or choroidal biopsy is a valuable investigation that often changes clinical management when carried out for specific indications in patients with uveitis of suspected malignant or infectious origin. Although it is likely to remain an investigation of last resort, it should be considered at an earlier stage when there is diagnostic uncertainty if severe visual loss is to be prevented.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Johnston RL,Tufail A,Lightman S,Luthert PJ,Pavesio CE,Cooling RJ,Charteris Ddoi
10.1016/j.ophtha.2002.10.002subject
Has Abstractpub_date
2004-03-01 00:00:00pages
522-8issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(03)01502-1journal_volume
111pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:OBJECTIVE:To study the clinical and electroretinographic findings of affected males and female carriers in a family with X-linked cone-rod dystrophy (COD-1). DESIGN:Observational case series. PARTICIPANTS:Twenty-five members of a five-generation pedigree were examined. METHODS:A history of visual impairment includin...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00086-5
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:We conducted a meta-analysis of randomized trials of ranibizumab for age-related macular degeneration (AMD) to elucidate systemic vascular risk. CLINICAL RELEVANCE:Although intravitreal vascular endothelial growth factor inhibitors are widely used to treat AMD, whether they produce systemic adverse effects ...
journal_title:Ophthalmology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ophtha.2014.05.022
更新日期:2014-11-01 00:00:00
abstract::Carbonic anhydrase inhibitors used in the treatment of glaucoma are rarely associated with blood dyscrasias. Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature. This report documents two cases of aplastic anemia, at least one of w...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35229-9
更新日期:1980-04-01 00:00:00
abstract::Sixty consecutive eyes that met the standard criteria for cataract surgery underwent phacoemulsification with insertion of a posterior chamber lens implant. The filtration angle of each eye was examined with routine postoperative gonioscopy in a prospective manner. Peripheral anterior synechia (PAS) overlying the posi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32564-2
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To determine if instrument cleaning techniques affect the rate of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). DESIGN:Retrospective case series. PARTICIPANTS:Two hundred ten eyes of 109 patients. METHODS:A record review was performed of all patients who underwent LASIK at th...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00876-4
更新日期:2002-02-01 00:00:00
abstract::Stromal keratitis and iritis developed in the left eye of a healthy 45-year-old man with no history of ocular disease, trauma, or contact lens wear. The clinical course over a 2-year period was characterized by progressive central disciform keratitis, recurrent anterior stromal patchy infiltration, and iritis which wa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Ten patients, all younger than 50 years of age, had a temporal cilioretinal artery occlusion associated with a nonischemic central retinal vein occlusion. On fluorescein angiography, the cilioretinal artery eventually filled in all but one eye. The cilioretinal artery showed pulsations on fluorescein angiography in fi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32245-0
更新日期:1991-05-01 00:00:00
abstract:PURPOSE:Motor vehicle accidents (MVAs) are a pandemic associated with human suffering and a burden to national economies. Whiplash-associated disorders (WADs) after MVAs are associated commonly with disability claims, many of which are related to vision. Convergence insufficiency (CI) leads to visual disability associa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.11.030
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Earlier studies of subperiosteal abscess secondary to sinusitis showed considerable variation in the clinical course and bacteriology. At one extreme, patients recovered with intravenous antibiotics alone; at the other extreme, complex pathogens persisted despite early surgical drainage and appropriate antib...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(94)31297-8
更新日期:1994-03-01 00:00:00
abstract::The treatment of severe congenital ptosis may include frontalis suspension or maximal levator resection. A previous study of 145 consecutive frontalis suspensions for congenital ptosis showed a fairly high recurrence rate, frequent granuloma formation, and significant brow scars. In 28 patients undergoing 32 maximal l...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33714-x
更新日期:1986-04-01 00:00:00
abstract::Rotational ipsilateral penetrating autokeratoplasty is useful in the treatment of certain nonprogressive corneal scars. The procedure alleviates difficulties with the availability of donor tissue and with graft rejection. A method is presented for determining the maximum clear central corneal area that can be obtained...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35561-5
更新日期:1978-12-01 00:00:00
abstract::Two unusual cases of benign lymphoproliferative disease associated with orbital and systemic involvement are described. Both have occurred in adults with longstanding histories and clinical manifestations that have mimicked lymphomas. The orbital disease has been both antecedent and subsequent to the systemic lesions....
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34189-6
更新日期:1984-09-01 00:00:00
abstract:PURPOSE:To determine whether intravitreal triamcinolone acetonide (IVTA) improves the efficacy of photodynamic therapy (PDT) with verteporfin in predominantly classic subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). DESIGN:Prospective randomized study. PARTICIPANTS:Six...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2006.04.039
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:Novel anterior segment optical coherence tomography (ASOCT) parameters associated with angle closure include anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and iris curvature (I-curv). We aimed to investigate ch...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2012.01.019
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To describe Descemet's membrane endothelial keratoplasty (DMEK) techniques, perioperative challenges, management, and visual and refractive outcomes. DESIGN:Prospective, multicenter, consecutive case series. PARTICIPANTS:Sixty eyes of 56 patients with Fuchs' endothelial dystrophy, pseudophakic bullous keratop...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2009.07.010
更新日期:2009-12-01 00:00:00
abstract::The authors studied 11 eyes of 10 patients who complained of a recent decrease in vision and whose eyes had the clinical appearance of stage 5 retinopathy of prematurity (ROP) as diagnosed by the presence of a dense, opaque retrolenticular membrane. Patients ranged in age from 4 to 33 years, and birth weights ranged f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32170-5
更新日期:1991-07-01 00:00:00
abstract::The authors used the Humphrey Retinal Analyzer to study the effect of acute changes in intraocular pressure (IOP) on the topography of the optic nerve head in normotensive and hypertensive eyes of cynomolgus monkeys. Chronically elevated IOP was produced monocularly in monkeys by argon laser angle treatment. In 8 hype...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32345-5
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:To analyze the temporal correlations of vascular endothelial growth factor (VEGF) suppression, morphologic recurrence of choroidal neovascularization (CNV), and visual acuity loss in eyes with exudative age-related macular degeneration (AMD) treated with ranibizumab. DESIGN:Nonrandomized, prospective, clini...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.07.041
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:Droperidol and the new serotonin-3 antagonists are effective drugs for the prophylaxis of postoperative nausea and vomiting (PONV). The aim of this trial was to evaluate whether dolasetron could be a substitute for droperidol, because the Food and Drug Administration has required a Black Box warning on the drop...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ophtha.2004.01.031
更新日期:2004-08-01 00:00:00
abstract:PURPOSE:Static threshold automated perimetry is a demanding test which can be tiring for some patients. The authors investigate how to optimize early stages of the test which can shorten examination time and improve performance. The effectiveness of measuring every point twice to improve diagnostic precision (proportio...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31612-x
更新日期:1993-04-01 00:00:00
abstract:PURPOSE:Intraoperative floppy iris syndrome (IFIS) caused by systemic alpha-blockers has been associated with an increased risk of cataract surgical complications when the surgeon was unaware of the medication history and did not anticipate its occurrence. This study was undertaken to evaluate the surgical outcomes and...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2007.01.011
更新日期:2007-05-01 00:00:00
abstract::Thirteen keratophakia patients were followed for 13 to 35 months. Eighteen cases of hyperopic keratomileusis or hyperopic keratomileusis using preserved corneal tissue were followed for 2 to 30 months. All 13 patients who underwent keratophakia achieved 20/50 or better acuity. All seven patients having hyperopic kerat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)34957-4
更新日期:1981-08-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of intravitreal aflibercept in patients with neovascular age-related macular degeneration (AMD) previously resistant to treatment with other anti-vascular endothelial growth factor agents. DESIGN:Prospective, open-label, noncontrolled, registered clinical trial. PARTICIPANTS:Fort...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2013.08.035
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To report the usefulness of the Boston type I keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) in the management of corneal opacification, corneal limbal stem cell failure, or both in a large single-surgeon series. DESIGN:Retrospective review of consecutive clinical case series. PARTICIPANTS...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.12.058
更新日期:2009-04-01 00:00:00
abstract::Seventeen patients having a posterior uveal melanoma underwent enucleation following documentation of tumor growth. Duration of follow-up from diagnosis to enucleation ranged from 3 weeks to 30 months. The mean rate of enlargement in cubic tumor volume was 56.3 mm3/mo for eight spindle cell melanomas and 270.3 mm3/mo ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34088-x
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the influence of disc neovascularization on the outcome of vitreous surgery for tractional retinal detachment (TRD) after branch retinal vein occlusion (BRVO). DESIGN:The study design was a retrospective case series. PARTICIPANTS:Twenty-two eyes of 22 patients who had undergo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)93021-4
更新日期:1998-03-01 00:00:00
abstract::Efforts have been made to develop noncorticosteroidal anti-inflammatory therapy. The goals of such therapy have been to eradicate the primary cause, prevent the initial tissue injury, moderate inflammatory response, and enhance tissue repair while minimizing and eliminating the undesirable aspects of the therapy. ...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(79)35546-4
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of a single intravitreal injection of ocriplasmin 125 μg across relevant subpopulations of patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction (VMT), including when associated with macular hole. DESIGN:Two multicenter, randomized, placebo-controlled, double-ma...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2014.07.045
更新日期:2015-01-01 00:00:00
abstract::Autosomal dominant vitreoretinochoroidopathy (ADVIRC), a recently described disease, is clinically characterized by a slowly progressive or stationary circumferential peripheral pigmentary retinopathy with fibrillar condensation of the vitreous. Histopathologic study of an 88-year-old patient with this disease showed ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32663-7
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To describe the histopathology of Molteno implant capsules in cases of primary and secondary glaucoma and to correlate them with surgical technique and clinical outcomes in quiet eyes. DESIGN:Human tissue study with clinicopathological correlation. MATERIALS:Seventy-five autopsy eyes or surgical pathology s...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00803-0
更新日期:2003-11-01 00:00:00