Abstract:
:A new method for the measurement of pulmonary gas exchange during inhalational anaesthesia is described which measures fresh gas and exhaust gas flows using carbon dioxide as an extractable marker gas. The theoretical precision of the method was compared by Monte Carlo modelling with other approaches which use marker gas dilution. A system was constructed for automated measurement of uptake of oxygen, nitrous oxide, volatile anaesthetic agent and elimination of carbon dioxide by an anaesthetized patient. The accuracy and precision of the method was tested in vitro on a lung gas exchange simulator, by comparison with simultaneous measurements made using nitrogen as marker gas and the Haldane transformation. Good agreement was obtained for measurement of simulated uptake or elimination of all gases studied over a physiologically realistic range of values. Mean bias for oxygen and nitrous oxide uptake was 0.003 l min(-1), for isoflurane 0.0001 l min(-1) and for carbon dioxide 0.001 l min(-1). Limits of agreement lay within 10% of the mean uptake rate for nitrous oxide, within 5% for oxygen and isoflurane and within 1% for carbon dioxide. The extractable marker gas method allows accurate and continuous measurement of gas exchange in an anaesthetic breathing system with any inspired gas mixture.
journal_name
Physiol Measjournal_title
Physiological measurementauthors
Peyton PJ,Robinson GJ,Terry D,Junor PAdoi
10.1088/0967-3334/25/1/001subject
Has Abstractpub_date
2004-02-01 00:00:00pages
1-14issue
1eissn
0967-3334issn
1361-6579journal_volume
25pub_type
杂志文章abstract::The main components responsible for the mechanical behavior of the arterial wall are collagen, elastin, and smooth muscle cells (SMCs) in the medial layer. We determined the structural and mechanical changes in porcine carotid arteries after administration of Triton® X-100, elastase, and collagenase using the inflatio...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/33/8/1335
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journal_title:Physiological measurement
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更新日期:2004-04-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:1995-08-01 00:00:00
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journal_title:Physiological measurement
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doi:10.1088/0967-3334/29/4/006
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更新日期:2006-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/0967-3334/35/6/1035
更新日期:2014-06-01 00:00:00
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journal_title:Physiological measurement
pub_type: 杂志文章,评审
doi:10.1088/0967-3334/26/3/R02
更新日期:2005-06-01 00:00:00
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更新日期:2017-05-01 00:00:00
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journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
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journal_title:Physiological measurement
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更新日期:2015-04-01 00:00:00
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journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
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更新日期:2008-06-01 00:00:00
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journal_title:Physiological measurement
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更新日期:1998-08-01 00:00:00
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journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/33/6/1015
更新日期:2012-06-01 00:00:00