Primary small bowel carcinoid tumor with bilateral breast metastases: report of 2 cases with different clinical presentations.

Abstract:

CONTEXT:Carcinoid tumor metastatic to the breast is uncommon and can closely mimic a mammary carcinoma. The differentiation of metastatic carcinoid tumor from primary breast tumor is important, however, owing to different clinical management and prognosis. OBJECTIVE:The purpose of this study was to describe 2 patients with bilateral metastatic carcinoid tumors to the breast with different clinical manifestations. DESIGN:We examined the radiological, clinical, cytologic, histologic, immunohistochemical, and ultrastructural features of these 2 cases. RESULTS:In case 1, the tumor presented initially as a stellate mass on mammogram and was diagnosed as grade II infiltrating ductal carcinoma. It was only after the discovery of small intestinal, liver, ovarian, and contralateral breast masses, as well as careful morphologic and immunohistochemical evaluations, that the true nature of the tumor was realized. In case 2, the tumor initially presented as a small intestinal tumor with liver metastases and bilateral breast masses. The breast masses were diagnosed accurately as metastatic carcinoid tumor by morphologic and immunohistochemical evaluations. CONCLUSIONS:Metastatic carcinoid tumor to the breast is uncommon, but poses a diagnostic challenge in that morphologically it can closely mimic a primary breast tumor. Careful attention to clinical features and the use of auxiliary immunohistochemical studies can help in arriving at the correct diagnosis.

journal_name

Arch Pathol Lab Med

authors

Mosunjac MB,Kochhar R,Mosunjac MI,Lau SK

doi

10.1043/1543-2165(2004)128<292:PSBCTW>2.0.CO;2

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

292-7

issue

3

eissn

0003-9985

issn

1543-2165

pii

OA3071

journal_volume

128

pub_type

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