Abstract:
:Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and collagen. Measurements were made 24 and 72 h and 7 and 90 days after the ischemic event in 29 patients with atherosclerotic ischemic stroke. Platelet aggregability was significantly decreased after 72 h compared to that at 24 h of stroke onset. However, platelet CD63 and P-selectin expression remained high even 90 days after the events. These findings suggest that platelet hyperactivation in atherosclerotic ischemic stroke may be sustained for a considerable period.
journal_name
Plateletsjournal_title
Plateletsauthors
Cha JK,Jo WS,Shin HC,Bae HR,Ho JM,Kim JWdoi
10.1080/09537100310001644024subject
Has Abstractpub_date
2004-02-01 00:00:00pages
3-7issue
1eissn
0953-7104issn
1369-1635pii
6JR2FH4WLFV2GE1Kjournal_volume
15pub_type
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