Abstract:
:The present report describes the radioactive labeling of polar lipids in in vitro cultures of Plasmodium falciparum as well as their extraction with organic solvents and their partial characterization by chemical and enzymatic methods. All substances detected could be cleaved by alkali, suggesting that they were esters rather than sphingolipids or compounds containing alkyl groups. Dolichol-cycle intermediates were not detected. Phosphatidylinositol, phosphatidylethanolamine, and phosphatidylcholine were labeled by fatty acids and inositol or ethanolamine, respectively, confirming their de novo synthesis by the parasite. Metabolic labeling with glucosamine and cleavage by phosphatidylinositol-specific phospholipase C provided evidence of the formation of N-acetyl-glucosaminyl-phosphatidylinositol, an obligate precursor in the biosynthesis of glycosylphosphatidylinositol membrane anchors of proteins.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Dieckmann-Schuppert A,Bender S,Holder AA,Haldar K,Schwarz RTdoi
10.1007/BF00931698subject
Has Abstractpub_date
1992-01-01 00:00:00pages
416-22issue
5eissn
0932-0113issn
1432-1955journal_volume
78pub_type
杂志文章abstract::The ultrastructure of alpha-bacteroids in relation to the fat-body cells of the lantern bug Pyrops candelaria was described. The fat-body-cell cytoplasm contained numerous mitochondria, rough endoplasmic reticula, vacuoles, and storage granules. Its nucleus had scattered chromatin materials. The alpha-bacteroid was en...
journal_title:Parasitology research
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journal_title:Parasitology research
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journal_title:Parasitology research
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journal_title:Parasitology research
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journal_title:Parasitology research
pub_type: 杂志文章
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journal_title:Parasitology research
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journal_title:Parasitology research
pub_type: 杂志文章
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journal_title:Parasitology research
pub_type: 杂志文章
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abstract::In temperate regions, some avian haemosporidian parasites have evolved seasonal transmission strategies, with chronic infections relapsing during spring and transmission peaking during the hosts' breeding season. Because lineages with seasonal transmission strategies are unlikely to produce gametocytes in winter, we p...
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journal_title:Parasitology research
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abstract::An endopeptidase specific to the Plasmodium falciparum erythrocytic schizont stage and to free merozoites was detected using the fluorogenic GlcA-Val-Leu-Gly-Lys(or Arg)-AEC substrate. The enzyme was purified by high performance liquid chromatography (HPLC); its optimal activity was around pH 7.5 and its isoelectric p...
journal_title:Parasitology research
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journal_title:Parasitology research
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journal_title:Parasitology research
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