Abstract:
BACKGROUND:Cytochrome c oxidase is a marker enzyme of the mitochondrial inner membrane. A change in the structure and activity of cytochrome c oxidase may alter the electron transport in the inner membrane, leading to insufficient adenosine triphosphate (ATP) production. ATP is essential for maintaining the function of cells. The aim of this study was to compare the expression of cytochrome c oxidase subunit I mRNA in placentas from normal and preeclamptic pregnancies. METHODS:By means of in situ hybridization, frozen sections of placentas from 23 women with preeclampsia and 29 women with uneventful pregnancies were examined. Digoxigenin (DIG)-labeled probes were used to detect the expression of cytochrome c oxidase subunit I mRNA in the placentas. The expression density was assessed by using an image disposal and analysis system. RESULTS:Positive expression of cytochrome c oxidase subunit I mRNA was found in the cytoplasm of villous syncytiotrophoblasts. The mean light density of cytochrome c oxidase subunit I mRNA in placental villi of normal pregnant women was 0.2638, and 0.1763 in women with preeclampsia, a statistically significant difference (P < 0.05). The number density of cytochrome c oxidase subunit I mRNA in placental villi was also significantly reduced in preeclamptic women compared with the control group (P < 0.05). CONCLUSIONS:Our study demonstrates a reduced amount of cytochrome c oxidase subunit I mRNA in preeclamptic placentas compared to control placentas. We hypothesize that a reduced expression may play a role in the pathophysiology of preeclampsia.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
He L,Wang Z,Sun Ydoi
10.1111/j.0001-6349.2004.00345.xsubject
Has Abstractpub_date
2004-02-01 00:00:00pages
144-8issue
2eissn
0001-6349issn
1600-0412pii
345journal_volume
83pub_type
杂志文章abstract:OBJECTIVE:To compare in controlled cardiovascular autonomic function tests the effects of hormone therapy (HT) on heart rate variability (HRV) responses in postmenopausal women with and without pretreatment hot flushes. DESIGN:A randomized placebo-controlled trial. SETTING:Finland, Helsinki University Central Hospita...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aogs.12164
更新日期:2013-08-01 00:00:00
abstract::We investigated the effect of a changed routine to identify women with a nonviable pregnancy, in order to utilize health care resources more efficiently during office hours rather than relying on emergency care services. From hospital register data about where and when women with miscarriages were treated, there was a...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2011.01144.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To assess trends for hysterectomy methods in the Nordic countries and to compare outcomes of hysterectomies in Finland done by trainees with those done by specialists. DESIGN:Register-based study. SETTING:NOMESCO database for the Nordic countries and the Finnish Hospital Discharge Register. POPULATION:Nati...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12654
更新日期:2015-07-01 00:00:00
abstract::Screening protocols for alloimmunization during pregnancy usually make a difference between primi- and multigravidae as well as between Rh(D) negative and Rh(D) positive pregnant women. We have evaluated a new screening program including antibody tests at 25 and 35 gestational weeks only, for all, and regardless of Rh...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349309021130
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVE:To identify prognostic factors influencing the outcome of infertility treatment using intrauterine insemination with donor semen (IUI-D). DESIGN:Retrospective study of all patients undergoing IUI-D between August 1st, 1990 and July 31st, 1998. SETTING:University-affiliated infertility clinic. PATIENTS:Thre...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2001.080004342.x
更新日期:2001-04-01 00:00:00
abstract::In a series of 43 healthy women menstrual blood loss was determined before and after insertion of copper IUD (Gravigard). The menstrual blood loss before insertion was compared with the blood loss 1, 2, 3, 4, 5, 6, 7 and 12 months after insertion. An increase amounting to approximately 20 ml per period without signifi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347509156760
更新日期:1975-01-01 00:00:00
abstract::Serum angiotensin-converting enzyme (SACE) levels were determined in normotensive pregnant subjects and patients with pre-eclampsia in the third trimester of pregnancy and 5 days, 3 and 6 months after parturition, and also in the first and second trimester in the normotensive group. SACE levels were reduced during pre...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348309156235
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION:Infections are a leading cause of mortality and morbidity in preschool children. We aimed to assess the impact of the co-occurrence of cesarean section, early birth and formula feeding on hospitalization with infection in early childhood. MATERIAL AND METHODS:Population-based retrospective record-linkage ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13371
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Cytogenetic studies in patients with reproductive failure AIM:To investigate the contribution of chromosomal abnormalities in sub fertility and in couples with repeated abortions. METHODS:Hundred and 13 couples who had at least two or more spontaneous abortions and 65 women and 63 men with infertility were...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2003.820109.x
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:To elucidate the sequences of changes in bone metabolism and bone density during pregnancy, lactation and postweaning. METHODS:Women were recruited (n = 254) in early pregnancy and followed for 2 years. Markers of bone formation (osteocalcin) and resorption (NTx) were measured at five occasions. Bone minera...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.00428.x
更新日期:2004-11-01 00:00:00
abstract::302 samples from 22 normal pregnancies were frozen and kept for the analysis of free calcium ion concentration [Ca2+](7.4) at 37 degrees C and pH 7.40, after equilibration with CO2. Individual regressions were performed, and the concentration was found to increase slightly but significantly (5%, p less than 0.005) wit...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348109158137
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:To describe pregnancy outcomes of adolescent and adult primigravidae receiving antimalarials and hematinic supplementation and compare findings with a survey in this area a decade earlier. DESIGN:Cross-sectional surveys in intervention and control sites. SETTING:Community, antenatal and delivery facilities ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349.2010.487892
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The purpose of the study was to evaluate the immediate outcome and complications of the tension-free vaginal tape (TVT) and laparoscopic mesh colposuspension (LC) procedures in the treatment of female stress urinary incontinence (SUI). METHODS:One hundred and twenty-eight patients suffering from urodynamica...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the distribution of circulating adiponectin isoforms in pregnant women with gestational diabetes mellitus (GDM) and compare isoform distribution changes 12 months after delivery. DESIGN CROSS-SECTIONAL STUDY SETTING:University Hospital. POPULATION:Sixty-four consecutive pregnant women who underw...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12137
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To describe quality of life in men and women who had terminated in vitro fertilization (IVF) within the public health system 4-5.5 years previously, and for whom treatment did not result in childbirth. DESIGN:Cross-sectional study. SETTING:Reproductive Unit, Sahlgrenska University Hospital, Gothenburg, Swed...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340802705956
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Early mother-infant relationships in preterm populations were evaluated in the context of a systematic review of the literature. DESIGN AND SETTING:A systematic search of three electronic databases (PsychINFO, PubMed and Cochrane Library) was undertaken. Three studies of maternal attachment, 18 studies of mo...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1600-0412.2011.01304.x
更新日期:2012-02-01 00:00:00
abstract::A prospective study of the clinical value of the symphysis-fundus (SF) distance was performed on 528 women, all at risk for developing intrauterine growth retardation (IUGR). Four different types of SF curves were observed and denoted as normal, static, catch-up and low. A normal or static SF curve predicted a normal ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348409155527
更新日期:1984-01-01 00:00:00
abstract::Tumors of the fallopian tube are extremely rare. A case of a papilloma occluding the right fallopian tube of a woman with primary sterility is reported. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348809004177
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To study the effect of hysterectomy or levonorgestrel-releasing intrauterine system (LNG-IUS) on premenstrual symptoms in women treated for menorrhagia. DESIGN:Secondary analysis of a randomized controlled trial. SETTING:Five university hospitals in Finland. SAMPLE:A cohort of 236 women, aged 35-49 years (...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0412.2011.01340.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Alteration in the vaginal flora has been associated with adverse pregnancy outcomes. The objective of this study was to examine the impact of changes in individual microflora on genital immunity among low-risk pregnant women in early pregnancy. DESIGN:Cross-sectional study. SETTING:Large, tertiary care, aca...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2011.01082.x
更新日期:2011-05-01 00:00:00
abstract::In a prospective, randomized study the duration and effectiveness of four different regimens of PCB were studied: Bupivacaine both with and without adrenaline, and chloroprocaine with and without adrenaline. The pain relief was immediate and almost complete in most patients in all four treatment groups. The duration o...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016348309155804
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Clinical guidelines for post-term management differ, and studies on women's attitudes are lacking. We aimed to assess the experiences and attitudes among women managed with serial antenatal monitoring or induction of labor, and the effects of post-term pregnancy on self-reports of quality of life. METHODS:W...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016340701416929
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Chorioamnionitis (CAM) may accelerate lung maturation in fetuses. It is possible that CAM prevents infant death after live birth. METHODS:A retrospective study of live-born singletons at < 32 weeks of gestation between 1993 and 1997. Perinatal risk factors for adverse outcomes were analyzed using a logistic...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the long-term prognosis of fecundity among couples with unexplained infertility and to compare pregnancy course and outcome in spontaneous versus treatment-related pregnancies. METHODS:A prospective follow-up study of 70 couples with a diagnosis of unexplained infertil...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::Current methodologies to assess the process of labor, such as tocodynamometry or intrauterine pressure catheters, fetal fibronectin, cervical length measurement and digital cervical examination, have several major drawbacks. They only measure the onset of labor indirectly and do not detect cellular changes characteris...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0412.2010.01031.x
更新日期:2011-02-01 00:00:00
abstract::Pulmonary hypertension is defined as pulmonary artery pressure greater than 30/15 mmHg. The etiologies of pulmonary hypertension can be divided into primary and secondary ones. The causes of the latter include long-lasting left-to-right shunts (congenital cardiac defects e.g. ventricular septal defect), pulmonary thro...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349409072516
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:To determine the performance of trained midwives in second trimester ultrasound screening for fetal structural abnormalities in a low-risk population. DESIGN:Retrospective study. SETTING:University Department of Obstetrics and Gynecology. POPULATION:About 13,882 women with singleton pregnancies. METHODS:T...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902934688
更新日期:2009-01-01 00:00:00
abstract::The level of blood natural killer (NK) cell activity was determined in relation to chlamydial infections. A group of 10 women who had recovered from chlamydial salpingitis was compared with a similar group who had had chlamydial cervicitis. Ten healthy female blood donors with no history of chlamydial infections serve...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348409155547
更新日期:1984-01-01 00:00:00
abstract:INTRODUCTION:Fetal growth restriction (FGR) is associated with poor perinatal outcomes. Screening and prevention tools for FGR, such as uterine artery Doppler imaging and aspirin, underperform in high-risk groups, compared with general antenatal populations. There is a paucity of sensitive screening tests for the early...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12823
更新日期:2016-03-01 00:00:00
abstract::Fluorescence polarization (FP) values were determined in 59 samples of amniotic fluid and in 56 samples of newborn gastric aspirate, collected from the 28th to 41st week of gestation. Both amniotic fluid and gastric aspirate FP values showed a significant correlation respectively with gestational age (r = 0.77; p less...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348509155140
更新日期:1985-01-01 00:00:00