Abstract:
:noni, the juice of the fruit from the Morinda citrifolia plant, has been used for centuries as a medicinal agent. We tested the effects of noni juice in a three-dimensional fibrin clot matrix model using human placental vein and human breast tumor explants as sources for angiogenic vessel development. Noni in concentrations of 5% (vol/vol) or greater was highly effective in inhibiting the initiation of new vessel sprouts from placental vein explants, compared with initiation in control explants in media supplemented with an equivalent amount of saline. These concentrations of noni were also effective in reducing the growth rate and proliferation of newly developing capillary sprouts. When used at a concentration of 10% in growth media, noni was able to induce vessel degeneration and apoptosis in wells with established capillary networks within a few days of its application. We also found that 10% noni juice in media was an effective inhibitor of capillary initiation in explants from human breast tumors. In tumor explants which did show capillary sprouting, the vessels rapidly degenerated (2-3 days) in those exposed to media supplemented with 10% noni.
journal_name
Angiogenesisjournal_title
Angiogenesisauthors
Hornick CA,Myers A,Sadowska-Krowicka H,Anthony CT,Woltering EAdoi
10.1023/B:AGEN.0000011800.04507.4bsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
143-9issue
2eissn
0969-6970issn
1573-7209pii
5255604journal_volume
6pub_type
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