Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni).

Abstract:

:noni, the juice of the fruit from the Morinda citrifolia plant, has been used for centuries as a medicinal agent. We tested the effects of noni juice in a three-dimensional fibrin clot matrix model using human placental vein and human breast tumor explants as sources for angiogenic vessel development. Noni in concentrations of 5% (vol/vol) or greater was highly effective in inhibiting the initiation of new vessel sprouts from placental vein explants, compared with initiation in control explants in media supplemented with an equivalent amount of saline. These concentrations of noni were also effective in reducing the growth rate and proliferation of newly developing capillary sprouts. When used at a concentration of 10% in growth media, noni was able to induce vessel degeneration and apoptosis in wells with established capillary networks within a few days of its application. We also found that 10% noni juice in media was an effective inhibitor of capillary initiation in explants from human breast tumors. In tumor explants which did show capillary sprouting, the vessels rapidly degenerated (2-3 days) in those exposed to media supplemented with 10% noni.

journal_name

Angiogenesis

journal_title

Angiogenesis

authors

Hornick CA,Myers A,Sadowska-Krowicka H,Anthony CT,Woltering EA

doi

10.1023/B:AGEN.0000011800.04507.4b

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

143-9

issue

2

eissn

0969-6970

issn

1573-7209

pii

5255604

journal_volume

6

pub_type

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