Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen.

abstract：:Follicular lymphoma (FL) is a low-grade B-cell non-Hodgkin's lymphoma (NHL) that frequently transforms into diffuse aggressive NHL. The majority of FLs display a t(14; 18) translocation that places the bcl-2 gene into juxtaposition with the lg heavy-chain (H) gene locus. Morphologically transformed malignant FL cells ...

journal_title：Blood

authors： Matolcsy A,Casali P,Warnke RA,Knowles DM

更新日期：1996-11-15 00:00:00

abstract：:The role of platelets in hemostasis and thrombosis is clearly established; however, the mechanisms by which platelets mediate inflammatory and immune pathways are less well understood. Platelets interact and modulate the function of blood and vascular cells by releasing bioactive molecules. Although the platelet is an...

journal_title：Blood

authors： Risitano A,Beaulieu LM,Vitseva O,Freedman JE

更新日期：2012-06-28 00:00:00

abstract：:High-dose melphalan followed by stem cell transplantation (HDM-SCT) has become the treatment of choice for patients with immunoglobulin light chain amyloidosis (AL). Unfortunately, treatment mortality can be excessive in certain subpopulations. We have noted that patients who gained more than 2% body weight during mob...

journal_title：Blood

authors： Leung N,Leung TR,Cha SS,Dispenzieri A,Lacy MQ,Gertz MA

更新日期：2005-11-15 00:00:00

abstract：:Natural killer (NK) cells contribute to host immunity, including tumor surveillance, through the production of interferon gamma (IFN-gamma). Although there is some knowledge about molecular mechanisms that induce IFN-gamma in NK cells, considerably less is known about the mechanisms that reduce its expression. Here, w...

journal_title：Blood

authors： Becknell B,Hughes TL,Freud AG,Blaser BW,Yu J,Trotta R,Mao HC,Caligiuri de Jesús ML,Alghothani M,Benson DM Jr,Lehman A,Jarjoura D,Perrotti D,Bates MD,Caligiuri MA

更新日期：2007-03-15 00:00:00

abstract：:Primary mediastinal large B-cell lymphoma (PMBCL) is a recognized non-Hodgkin lymphoma entity with unique pathologic, clinical, and molecular characteristics distinct from those of other diffuse large B-cell lymphomas. Immunohistochemical characterization and molecular studies strongly suggest that PMBCL is of germina...

journal_title：Blood

authors： Steidl C,Gascoyne RD

更新日期：2011-09-08 00:00:00

abstract：:We report 2 novel, cryptic chromosomal abnormalities in precursor B-cell acute lymphoblastic leukemia (BCP-ALL): a translocation, either t(X;14)(p22;q32) or t(Y;14)(p11;q32), in 33 patients and an interstitial deletion, either del(X)(p22.33p22.33) or del(Y)(p11.32p11.32), in 64 patients, involving the pseudoautosomal ...

journal_title：Blood

authors： Russell LJ,Capasso M,Vater I,Akasaka T,Bernard OA,Calasanz MJ,Chandrasekaran T,Chapiro E,Gesk S,Griffiths M,Guttery DS,Haferlach C,Harder L,Heidenreich O,Irving J,Kearney L,Nguyen-Khac F,Machado L,Minto L,Majid A,

更新日期：2009-09-24 00:00:00

abstract：:To investigate the tropism of the T-lymphotropic human herpesvirus 7 (HHV-7) for hematopoietic progenitors, cord blood CD34(+) cells were inoculated in vitro with HHV-7 and then induced to differentiate along the granulocytic and erythroid lineages by the addition of appropriate cytokine cocktails. In semisolid assays...

journal_title：Blood

authors： Mirandola P,Secchiero P,Pierpaoli S,Visani G,Zamai L,Vitale M,Capitani S,Zauli G

更新日期：2000-07-01 00:00:00

abstract：:The membrane skeleton of normal erythrocytes is largely organized into a hexagonal lattice of junctional complexes (JC) crosslinked by spectrin tetramers, and occasional double tetramers and hexamers. To explore possible skeletal alterations in hereditary spherocytosis (HS), elliptocytosis (HE), and pyropoikilocytosis...

journal_title：Blood

authors： Liu SC,Derick LH,Agre P,Palek J

更新日期：1990-07-01 00:00:00

abstract：:The purpose of this study was to determine the relative merits of idarubicin and daunorubicin in acute myeloid leukemia (AML) therapy. Thirty-two sites provided 214 previously untreated adults with AML aged 15 years or more who were randomized to receive for induction therapy cytarabine 100 mg/m2/d as a continuous 7-d...

journal_title：Blood

authors： Wiernik PH,Banks PL,Case DC Jr,Arlin ZA,Periman PO,Todd MB,Ritch PS,Enck RE,Weitberg AB

更新日期：1992-01-15 00:00:00

abstract：:The translocation between chromosomes 8 and 21, t(8;21) (q22;q22), is the most frequent abnormality in acute myeloid leukemia (AML) with French-American-British type M2 (FAB-M2) morphology. The breakpoints in this translocation have been characterized at the molecular level, and the genes involved are AML1 on chromoso...

journal_title：Blood

authors： Nucifora G,Larson RA,Rowley JD

更新日期：1993-08-01 00:00:00

abstract：:Long-living memory stem T cells (T(SCM)) with the ability to self-renew and the plasticity to differentiate into potent effectors could be valuable weapons in adoptive T-cell therapy against cancer. Nonetheless, procedures to specifically target this T-cell population remain elusive. Here, we show that it is possible ...

journal_title：Blood

authors： Cieri N,Camisa B,Cocchiarella F,Forcato M,Oliveira G,Provasi E,Bondanza A,Bordignon C,Peccatori J,Ciceri F,Lupo-Stanghellini MT,Mavilio F,Mondino A,Bicciato S,Recchia A,Bonini C

更新日期：2013-01-24 00:00:00

abstract：:A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One main route of K(+) loss in the RBC is the Gardos channel, a calcium (C...

journal_title：Blood

authors： Stocker JW,De Franceschi L,McNaughton-Smith GA,Corrocher R,Beuzard Y,Brugnara C

更新日期：2003-03-15 00:00:00

abstract：:Two tumor necrosis factor receptors (TNFRs) with molecular weights of 55 kD (TNFR-p55) and 75 kD (TNFR-p75) have recently been identified and cloned. In previous studies, TNFR-p55 has been shown to exclusively mediate bidirectional effects of TNF-alpha on committed bone marrow granulocyte-macrophage progenitor cells, ...

journal_title：Blood

authors： Rusten LS,Jacobsen SE

更新日期：1995-02-15 00:00:00

abstract：:Whether platelet volume increases during the morphological changes preceding aggregation has been investigated. Previous research is controversial; resistive-counting techniques reveal an increase, centrifugal methods do not. Platelets were sized with a computerized, resistive-particle counter before and after incubat...

journal_title：Blood

authors： Gear AR

更新日期：1981-09-01 00:00:00

abstract：:Many lineage-specific developmental regulator genes are transcriptionally primed in embryonic stem (ES) cells; RNA Pol(II) is bound at their promoters but is prevented from productive elongation by the activity of polycomb repressive complexes (PRC) 1 and 2. This epigenetically poised state is thought to enable ES cel...

journal_title：Blood

authors： Mazzarella L,Jørgensen HF,Soza-Ried J,Terry AV,Pearson S,Lacaud G,Kouskoff V,Merkenschlager M,Fisher AG

更新日期：2011-01-06 00:00:00

abstract：:Increasing evidence indicates that the gut microbiota is closely associated with acute graft-versus-host disease (aGVHD) in stem cell transplantation (SCT). Fecal microbiota transplantation (FMT) could represent an alternative treatment option for aGVHD. However, FMT for SCT patients carries a potential risk of infect...

journal_title：Blood

authors： Kakihana K,Fujioka Y,Suda W,Najima Y,Kuwata G,Sasajima S,Mimura I,Morita H,Sugiyama D,Nishikawa H,Hattori M,Hino Y,Ikegawa S,Yamamoto K,Toya T,Doki N,Koizumi K,Honda K,Ohashi K

更新日期：2016-10-20 00:00:00

abstract：:Antiangiogenic agents and therapeutic strategies have entered the clinical oncology arena. The classical tumor size measurements defined to monitor efficacy of chemotherapy, however, might not be appropriate for these newer therapeutics. We previously found that circulating endothelial cells (CECs) were increased in n...

journal_title：Blood

authors： Mancuso P,Colleoni M,Calleri A,Orlando L,Maisonneuve P,Pruneri G,Agliano A,Goldhirsch A,Shaked Y,Kerbel RS,Bertolini F

更新日期：2006-07-15 00:00:00

abstract：:Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by clonal myeloproliferation, dysregulated kinase signaling, and release of abnormal cytokines. In recent years, important progress has been made in the knowledge of the molecular biology and the prognostic assessment of MF. Convention...

journal_title：Blood

authors： Cervantes F

更新日期：2014-10-23 00:00:00

abstract：:The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is rare in T-cell acute lymphoblastic leukemia (T-ALL). We recently identified NUP214-ABL1 as a variant ABL1 fusion gene in 6% of T-ALL patients. Here we describe the identification of another ...

journal_title：Blood

authors： De Keersmaecker K,Graux C,Odero MD,Mentens N,Somers R,Maertens J,Wlodarska I,Vandenberghe P,Hagemeijer A,Marynen P,Cools J

更新日期：2005-06-15 00:00:00

abstract：:The promising activity of BET protein inhibitors (BETi's) is compromised by adaptive or innate resistance in acute myeloid leukemia (AML). Here, modeling of BETi-persister/resistance (BETi-P/R) in human postmyeloproliferative neoplasm (post-MPN) secondary AML (sAML) cells demonstrated accessible and active chromatin i...

journal_title：Blood

authors： Saenz DT,Fiskus W,Mill CP,Perera D,Manshouri T,Lara BH,Karkhanis V,Sharma S,Horrigan SK,Bose P,Kadia TM,Masarova L,DiNardo CD,Borthakur G,Khoury JD,Takahashi K,Bhaskara S,Lin CY,Green MR,Coarfa C,Crews CM,Versto

更新日期：2020-04-09 00:00:00

abstract：:The International Lymphoma Radiation Oncology Group (ILROG) guidelines for using radiation therapy (RT) in hematological malignancies are widely used in many countries. The emergency situation created by the COVID-19 pandemic may result in limitations of treatment resources. Furthermore, in recognition of the need to ...

journal_title：Blood

authors： Yahalom J,Dabaja BS,Ricardi U,Ng A,Mikhaeel NG,Vogelius IR,Illidge T,Qi S,Wirth A,Specht L

更新日期：2020-05-21 00:00:00

abstract：:Lumiliximab is a chimeric macaque-human monoclonal antibody to CD23, a protein expressed on virtually all chronic lymphocytic leukemia (CLL) cells. We examined the ability of lumiliximab to mediate apoptosis, antibody-dependent cellular cytotoxicity, and complement-dependent cytotoxicity against primary CLL cells and ...

journal_title：Blood

authors： Pathan NI,Chu P,Hariharan K,Cheney C,Molina A,Byrd J

更新日期：2008-02-01 00:00:00

abstract：:Immunosuppressive therapy can produce hematologic improvement in a large proportion of patients with severe aplastic anemia. Antithymocyte globulin (ATG) is the current treatment of choice for patients who do not have histocompatible sibling donors or who are otherwise inegligible for allogeneic bone marrow transplant...

journal_title：Blood

authors： Rosenfeld SJ,Kimball J,Vining D,Young NS

更新日期：1995-06-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) can kill target cells by the granule/exocytosis pathway or the Fas-mediated apoptosis pathway. The sensitivity of chronic lymphocytic leukemia (CLL) B cells to CTL-mediated apoptosis before and after CD40 activation was examined. Resting or CD40-activated CLL cells were found to be equal...

journal_title：Blood

authors： Chu P,Wierda WG,Kipps TJ

更新日期：2000-06-15 00:00:00

abstract：:From ten patients with advanced malignant disease involving the bone marrow, autologous hematopoietic stem cells were collected from the peripheral blood during eight four-hour pheresis procedures and cryopreserved. No manipulations to increase the number of stem cells circulating in the blood were used during the col...

journal_title：Blood

authors： Kessinger A,Armitage JO,Landmark JD,Smith DM,Weisenburger DD

更新日期：1988-03-01 00:00:00

abstract：:We evaluated the efficacy of umbilical cord blood (UCB) in the setting of a nonmyeloablative regimen consisting of fludarabine (200 mg/m2), cyclophosphamide (50 mg/kg), and a single fraction of total body irradiation (200 cGy) with cyclosporine and mycophenolate mofetil for posttransplantation immunoprophylaxis. The t...

journal_title：Blood

authors： Brunstein CG,Barker JN,Weisdorf DJ,DeFor TE,Miller JS,Blazar BR,McGlave PB,Wagner JE

更新日期：2007-10-15 00:00:00

abstract：:In this issue of Blood, Palomo et al provide new insight into the mechanism of action of defibrotide as an endothelial protective agent, while Richardson et al present the encouraging final results of the phase 3 clinical study of defibrotide for the treatment of severe hepatic veno-occlusive disease (VOD), showing a ...

journal_title：Blood

authors： Arai S

更新日期：2016-03-31 00:00:00

abstract：:Little is known about mechanisms involved in skin-specific homing of cutaneous T-cell lymphoma (CTCL). Chemokine/chemokine receptor interactions have been implicated in the homing of lymphoma cells to various tissue sites. We investigated tissue samples and tumor cell suspensions of patients with CD30(+) CTCL (n = 8) ...

journal_title：Blood

authors： Kleinhans M,Tun-Kyi A,Gilliet M,Kadin ME,Dummer R,Burg G,Nestle FO

更新日期：2003-02-15 00:00:00

abstract：:Myeloma is a unique hematologic malignancy that exclusively homes in the bone marrow and induces massive osteoclastic bone destruction presumably by producing cytokines that promote the differentiation of the hematopoietic progenitors to osteoclasts (osteoclastogenesis). It is recognized that neighboring bone marrow s...

journal_title：Blood

authors： Michigami T,Shimizu N,Williams PJ,Niewolna M,Dallas SL,Mundy GR,Yoneda T

更新日期：2000-09-01 00:00:00

abstract：:Human alpha2-antiplasmin (alpha2AP), also known as alpha2-plasmin inhibitor, is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. There are 2 N-terminal forms of alpha2AP that circulate in human plasma: a 464-residue protein with Met as the N-terminus, Met-alpha2AP, and a 452-residue version w...

journal_title：Blood

authors： Lee KN,Jackson KW,Christiansen VJ,Chung KH,McKee PA

更新日期：2004-05-15 00:00:00