Are peripheral opioid antagonists the solution to opioid side effects?

abstract：:Patients who undergo infrainguinal revascularization surgery are at increased risk for perioperative thrombotic complications. Aspirin decreases thrombotic events in the nonoperative setting; however, aspirin is often discontinued to avoid perioperative hemorrhagic complications. We used a decision analysis to determi...

journal_title：Anesthesia and analgesia

authors： Neilipovitz DT,Bryson GL,Nichol G

更新日期：2001-09-01 00:00:00

abstract：:The anesthetic effect of lidocaine was evaluated in rats by determining the change in anesthetic requirement of cyclopropane MAC that was produced by blood concentrations of lidocaine in the clinically useful range. A linear reduction in anesthetic requirement was produced with concentrations up to 1 mug/ml. Further i...

journal_title：Anesthesia and analgesia

authors： DiFazio CA,Neiderlehner JR,Burney RG

更新日期：1976-11-01 00:00:00

abstract：UNLABELLED:Surgery causes changes in hemostasis, leading to a hypercoagulable state that has been linked to both arterial and venous thrombotic complications. The etiology of this state is unknown, but many investigators have hypothesized that perioperative neuroendocrine changes are responsible. We have previously dem...

journal_title：Anesthesia and analgesia

authors： Rosenfeld BA,Nguyen ND,Sung I,Faraday N

更新日期：1998-03-01 00:00:00

abstract：UNLABELLED:Carpal tunnel release is often performed as an outpatient procedure. We designed this retrospective study to assess the effect of different anesthesia techniques on intraoperative cardiovascular stability and discharge time. According to the anesthesia technique received, 62 consecutive patients were categor...

journal_title：Anesthesia and analgesia

authors： Gebhard RE,Al-Samsam T,Greger J,Khan A,Chelly JE

更新日期：2002-08-01 00:00:00

abstract：UNLABELLED:The electrophysiologic effects of sevoflurane are not well characterized in humans. Among patients with refractory epilepsy, this study compared 1) electroencephalographic (EEG) interictal spike activity during wakefulness and sevoflurane anesthesia, and 2) electrocorticographically (ECoG) recorded intericta...

journal_title：Anesthesia and analgesia

authors： Watts AD,Herrick IA,McLachlan RS,Craen RA,Gelb AW

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Neuropathic pain is a result of a primary lesion or dysfunction of the peripheral or central nervous system, and its treatment is challenging. Animal models have been helpful in understanding mechanisms of neuropathic pain and in developing new treatment strategies. In this study, we examined the effect of p...

journal_title：Anesthesia and analgesia

authors： Ozsoylar O,Akçali D,Cizmeci P,Babacan A,Cahana A,Bolay H

更新日期：2008-10-01 00:00:00

abstract：:A 91-yr-old man (57 kg, 156 cm, ASA III) received an infraclavicular brachial plexus block for surgery of bursitis of the olecranon. Twenty minutes after infraclavicular injection of 30 mL of mepivacaine 1% (Scandicain) and 5 min after supplementation of 10 mL of prilocaine 1% (Xylonest) using an axillary approach, th...

journal_title：Anesthesia and analgesia

authors： Litz RJ,Roessel T,Heller AR,Stehr SN

更新日期：2008-05-01 00:00:00

abstract：:Patients undergoing potentially painful interventional radiological procedures generally require a combination of analgesia and sedation. This sedation/analgesia should allow the patient to communicate while also remaining calm. Bispectral index (BIS) monitoring could be useful in achieving this. The primary end-point...

journal_title：Anesthesia and analgesia

authors： Dahaba AA,Lischnig U,Kronthaler R,Bornemann H,Georgiev V,Rehak PH,Metzler H

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Tissue factor pathway inhibitor (TFPI) is a 40-kDa, endogenous protein that inhibits tissue factor (TF)-initiated coagulation by bonding with activated factor X (FXa). The TFPI/FXa complex then subsequently binds with TF/activated factor VII (FVIIa) complex, ultimately inhibiting thrombin generation. Heparin...

journal_title：Anesthesia and analgesia

authors： Audu P,Nielsen VG,Armstead V,Powell G,Kim J,Kim L,Mehta M

更新日期：2006-10-01 00:00:00

abstract：UNLABELLED:Reports of transient neurological symptoms with the use of subarachnoid lidocaine has generated interest in alternate local anesthetics of intermediate duration, such as mepivacaine. This prospective randomized, double-blinded, dose-response study examined the anesthetic and recovery profiles of 60- and 80-m...

journal_title：Anesthesia and analgesia

authors： Pawlowski J,Sukhani R,Pappas AL,Kim KM,Lurie J,Gunnerson H,Corsino A,Frey K,Tonino P

更新日期：2000-09-01 00:00:00

abstract：UNLABELLED:Acute withdrawal syndromes, including agitation and a long weaning time, are common adverse effects after long-term sedation with midazolam. We performed this study to determine whether the sequential use of midazolam and propofol could reduce adverse effects as compared with midazolam alone. We studied 26 p...

journal_title：Anesthesia and analgesia

authors： Saito M,Terao Y,Fukusaki M,Makita T,Shibata O,Sumikawa K

更新日期：2003-03-01 00:00:00

abstract：:Wound perfusion and oxygenation are important determinants of the development of postoperative wound infections. Supplemental fluid administration significantly increases tissue oxygenation in surrogate wounds in the subcutaneous tissue of the upper arm in perioperative surgical patients. We tested the hypothesis that...

journal_title：Anesthesia and analgesia

authors： Kabon B,Akça O,Taguchi A,Nagele A,Jebadurai R,Arkilic CF,Sharma N,Ahluwalia A,Galandiuk S,Fleshman J,Sessler DI,Kurz A

更新日期：2005-11-01 00:00:00

abstract：UNLABELLED:Rapacuronium (Org 9487) is a rapid-onset and short- to intermediate-acting muscle relaxant. Its 3-desacetyl metabolite, Org 9488, also exerts neuromuscular-blocking activity that may become apparent after prolonged maintenance of relaxation with rapacuronium. In this study, the pharmacokinetic behavior (n = ...

journal_title：Anesthesia and analgesia

authors： Schiere S,Proost JH,Schuringa M,Wierda JM

更新日期：1999-03-01 00:00:00

abstract：UNLABELLED:We investigated the role of cardiopulmonary bypass (CPB) in compromised lung function associated with cardiac surgery. Low-frequency respiratory impedance (Zrs) was measured in patients undergoing cardiac surgery with (n = 30; CPB group) or without (n = 29; off-pump coronary artery bypass [OPCAB] group) CPB....

journal_title：Anesthesia and analgesia

authors： Babik B,Asztalos T,Peták F,Deák ZI,Hantos Z

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Midazolam is the most commonly used premedication in children. It has been shown to be more effective than parental presence or placebo in reducing anxiety and improving compliance at induction of anesthesia. Clonidine, an alpha(2) agonist, has been suggested as an alternative. Dexmedetomidine is a more alph...

journal_title：Anesthesia and analgesia

authors： Yuen VM,Hui TW,Irwin MG,Yuen MK

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:An anesthesia department implemented scheduling of anesthetics outside of operating rooms (non-OR) by clerks and nurses from other departments using its hospital's enterprise-wide scheduling system. METHODS:Observational studies chronicled the change over 2 yr as non-OR time was allocated by specialty, and ...

journal_title：Anesthesia and analgesia

authors： Dexter F,Xiao Y,Dow AJ,Strader MM,Ho D,Wachtel RE

更新日期：2007-12-01 00:00:00

abstract：:This study was performed to compare the efficacy of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting (PONV) and to compare the possible adverse effects of these drugs in gynecologic incontinence surgery. Using a randomized, double-blind study design, we studied 150 women under...

journal_title：Anesthesia and analgesia

authors： Purhonen S,Kauko M,Koski EM,Nuutinen L

更新日期：1997-03-01 00:00:00

abstract：UNLABELLED:We tested baicalin for its antiinflammatory and analgesic effects (and the mechanisms) in a rat model of carrageenan-evoked thermal hyperalgesia. Pre- or posttreatment with baicalin (10, 30, or 100 mg/kg intraperitoneally) caused a significant analgesic effect with a similar effect of dose-matched ibuprofen....

journal_title：Anesthesia and analgesia

authors： Chou TC,Chang LP,Li CY,Wong CS,Yang SP

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Vascular access is often technically difficult in children because of the small caliber and impalpability of the veins. In this study, we sought to determine if use of the Vein Entry Indicator Device (VEIDtrade mark) in children facilitates peripheral venous access. METHODS:Two-hundred-two healthy (ASA grad...

journal_title：Anesthesia and analgesia

authors： Simhi E,Kachko L,Bruckheimer E,Katz J

更新日期：2008-11-01 00:00:00

abstract：:To determine the effect of liver disease on the pharmacokinetics of rocuronium, the authors administered 0.6 mg/kg (twice the ED95) to 10 patients with liver disease and compared these results to values in 10 healthy surgical patients. Anesthesia was induced with thiopental and maintained with isoflurane (0.9%-1.1% en...

journal_title：Anesthesia and analgesia

authors： Magorian T,Wood P,Caldwell J,Fisher D,Segredo V,Szenohradszky J,Sharma M,Gruenke L,Miller R

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Although invasive monitoring is the standard method for intracranial pressure (ICP) measurement, it is not without potential for serious complications. Noninvasive methods have been proposed as alternatives to invasive ICP monitoring. The study aimed to investigate the diagnostic accuracy of the currently av...

journal_title：Anesthesia and analgesia

authors： Sallam A,Abdelaal Ahmed Mahmoud M Alkhatip A,Kamel MG,Hamza MK,Yassin HM,Hosny H,Younis MI,Ramadan E,Algameel HZ,Abdelhaq M,Abdelkader M,Mills KE,Mohamed H

更新日期：2020-09-24 00:00:00

abstract：UNLABELLED:In a randomized trial, we compared topical anesthesia by a lidocaine-prilocaine cream (EMLA; Laboratorie ASTRA, Manterre, France) with subcutaneous local lidocaine infiltration for radial artery cannulation. Patients included 538 adults scheduled for coronary angiography using a radial approach. EMLA was app...

journal_title：Anesthesia and analgesia

authors： Joly LM,Spaulding C,Monchi M,Ali OS,Weber S,Benhamou D

更新日期：1998-08-01 00:00:00

abstract：:Three-centimetre linear incisions were made in 90 young male Lew/f Mai rats by scalpel through skin to the investing fascia of the left flank. The skin was undermined sharply for a distance of 0.5 cm along both sides of the entire length of the incision. The wound site was closed per primam with Michel clips and left ...

journal_title：Anesthesia and analgesia

authors： Shah NK,Kripke BJ,Sanzone CF,Cosman EB

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:In this study, we sought to determine whether a simplified ultrasound measurement of the largest transverse diameter, using a standard ultrasound machine, could be used to diagnose postoperative urinary retention (POUR). This method may replace expensive bladder volume measuring devices or a more complex ult...

journal_title：Anesthesia and analgesia

authors： Daurat A,Choquet O,Bringuier S,Charbit J,Egan M,Capdevila X

更新日期：2015-05-01 00:00:00

abstract：UNLABELLED:Our aim in this study, performed using a closed cranial window preparation, was to investigate the effect of systemic pretreatment with dexmedetomidine on cerebrovascular response to isoflurane or sevoflurane. After instrumentation under pentobarbital anesthesia, 48 dogs were assigned to one of two groups: t...

journal_title：Anesthesia and analgesia

authors： Ohata H,Iida H,Dohi S,Watanabe Y

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Spinal cord monitoring is associated with a significantly lower rate of neurologic deficits after deformity surgery, and has been shown to have predictive value in cervical, thoracic, and lumbar surgery. Lower extremity motor evoked potentials (MEPs) are particularly sensitive to anesthetics and physiologic ...

journal_title：Anesthesia and analgesia

authors： Deiner SG,Kwatra SG,Lin HM,Weisz DJ

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Pain in sickle cell disease (SCD) is characterized by episodes of acute pain, primarily responsible for acute health care utilization, and persistent chronic pain. Pain severity and frequency vary significantly among patients with SCD. In this study, we investigated the possible contribution of monoamine gen...

journal_title：Anesthesia and analgesia

authors： Jhun E,He Y,Yao Y,Molokie RE,Wilkie DJ,Wang ZJ

更新日期：2014-11-01 00:00:00

abstract：:One of the most prevalent symptoms after major surgery is pain. When postoperative pain treatment is unsatisfactory, it can lead to poor surgical recovery, decreased quality of life, and increased health care costs. Current analgesics, single or in combination, have limited efficacy due to low potency, limited duratio...

journal_title：Anesthesia and analgesia

authors： Cata JP,Gorur A,Yuan X,Berg NK,Sood AK,Eltzschig HK

更新日期：2020-06-01 00:00:00

abstract：:Combinations of alpha 2 agonists and opiates are used in the clinical management of pain to harness their potential synergistic interaction for analgesia while limiting their side-effects. To better predict the clinical consequences of this combination, we studied the behavioral effects of dexmedetomidine, a highly se...

journal_title：Anesthesia and analgesia

authors： Hayashi Y,Guo TZ,Maze M

更新日期：1996-09-01 00:00:00

abstract：:Elevated serum ammonia may play a role in central nervous system derangement after transurethral resection of the prostate. Glycine used as a surgical irrigant for prostate resection produces ammonia as a by-product after liver and renal metabolism. The presence of liver dysfunction often leads to an inability to remo...

journal_title：Anesthesia and analgesia

authors： Frink EJ Jr,DiGiovanni DA,Davis JR,Brown BR Jr

更新日期：1989-12-01 00:00:00