A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane.

Abstract:

BACKGROUND:The aim of this study was to evaluate the health effects of exposure mainly to 1-bromopropane, which is an alternative to ozone-depleting solvents, and to establish biomarkers for assessing 1-bromopropane exposure. METHODS:Twenty-four female and 13 male workers of a 1-bromopropane-factory were interviewed, and their urine and blood samples were collected. Measured parameters included 1-bromopropane levels in the factory, as well as individual exposure levels, urinary 1-bromopropane levels, enzymatic activity and M subunit's concentration of serum creatine kinase (CK). RESULTS:Frequent symptoms reported by workers exposed to 1-bromopropane were nose, throat, and eyes irritation or malaise and/or headache. Urinary 1-bromopropane levels correlated significantly with individual exposure levels, but enzymatic activity or CK-M subunit did not. CONCLUSIONS:The symptoms suggested irritation of the mucous membrane and possible adverse effects on the central nervous system. There were no severe chronic symptoms suggestive of neurological damage in workers exposed to less than 170 ppm. Urinary 1-bromopropane level may be a good indicator of exposure. Am. J. Ind. Med. 45:63-75, 2004.

journal_name

Am J Ind Med

authors

Ichihara G,Li W,Ding X,Peng S,Yu X,Shibata E,Yamada T,Wang H,Itohara S,Kanno S,Sakai K,Ito H,Kanefusa K,Takeuchi Y

doi

10.1002/ajim.10320

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

63-75

issue

1

eissn

0271-3586

issn

1097-0274

journal_volume

45

pub_type

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