Abstract：
BACKGROUND:Natural killer (NK) cells are a third population of lymphocytes that can kill certain tumor cells. This killing is regulated by signals received through activating and inhibitory receptors. 2B4 (CD244), a member of the CD2 subset of Immunoglobulin superfamily, was identified as an activating receptor on NK cells. Interaction of 2B4 with its ligand CD48 or anti-2B4 mAb stimulates NK cell cytolytic function as well as production of INF-gamma. MATERIALS AND METHODS:A murine tumor model was used to study the in vivo role of 2B4. 2B4 and CD48 were activated in vivo by injecting anti-2B4 and anti-CD48 monoclonal antibodies. RESULTS:Activation of 2B4 or CD48 resulted in a five-fold reduction in tumor metastasis. IFN-gamma knockout mice had a two-fold increase in metastasis as compared to wild-type after 2B4 activation. CONCLUSION:Activation of 2B4 and CD48 reduces metastasis of B16F10 melanoma cells and this anti-tumor effect involves both cytolytic function and cytokine production.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Johnson LA,Vaidya SV,Goldfarb RH,Mathew PAsubject
Has Abstractpub_date
2003-09-01 00:00:00pages
3651-5issue
5Aeissn
0250-7005issn
1791-7530journal_volume
23pub_type
杂志文章abstract：BACKGROUND:DeltaNp63 is an isoform of the p53 homolog p63, which lacks an amino-terminal transactivation domain. The aim of this study was to detect the deltaNp63 expression in the squamous carcinoma component of adenosquamous carcinoma and evaluate its usefulness as a specific squamous carcinoma marker. PATIENTS AND ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：:Advanced or metastatic pancreatic cancer is an incurable disease. The main treatment is chemotherapy with cytotoxic agents. On the basis of our experience in clinical trials, the objectives have been to determine response rate, life prolongation and clinical benefit. In our trials and in those of other authors, all of...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2008-03-01 00:00:00
abstract：:The present study assessed the immunohistochemical expression of ras p21 oncoprotein in 41 cases of benign and cancerous lesions of the prostate gland and correlated p21 expression with survival of patients operated for prostate cancer. Our results show that p21 is detected in both categories of patients, the expressi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Malignant cells appear to possess a special aptitude for survival. We attempted to prove this in vitro by acute nutritional and energy deprivation as a survival threat. A phosphate-buffered saline (PBS) survival test in cell culture allowed static observations. These were supplemented by classic and quantitative phase...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：AIM:To estimate the clinical outcomes of induction chemotherapy (IC) followed by standard chemoradiotherapy (CRT) and CRT alone in patients with locally advanced human papilloma virus (HPV)-negative oropharyngeal squamous cell carcinoma. PATIENTS AND METHODS:Consecutive patients with histologically-proven HPV-negative...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11276
更新日期：2016-12-01 00:00:00
abstract：:The sodium iodide symporter (NIS) is a plasma membrane protein that mediates active uptake of inorganic iodide from plasma into thyroid cells. Expression of the NIS gene in tumor cells may provide a novel mechanism for treating cancer. Previously, we cloned cDNA of rat NIS into the retroviral vector LXSN, transduced h...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Vitamin D is known for its anti-cancerogenous potential. Prostaglandin E2 (PGE2) is a proliferation and inflammation activating agent. The production of PGE2 is dependent on the activity of cyclooxygenase-2 (COX-2). A link between vitamin D and PGE2 metabolism was recently shown. MATERIALS AND METHODS:In MD...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Cancer of the oesophagus is the most common gastrointestinal malignancy in South African blacks. The aim of this study was to determine the reversible and irreversible lipid peroxidation in cancer of the oesophagus; a feature that has not been assessed before in this or other cancer tissue. METHODS:Biopsies...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:Hurthle cell neoplasms may occur as a benign adenoma or carcinoma; the latter displays comparatively aggressive clinical behaviour. Fine-needle aspiration cytology (FNAC) represents a reliable tool for screening Hurthle cell lesions before surgery. Nevertheless, the cytological interpretation of these lesion...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Since tumor markers can be increased in the course of many benign diseases, the aim of this study was to verify if this also occurs in the course of rheumatic diseases. MATERIALS AND METHODS:We investigated the incidence and characteristics of Tumor M2-PK in the EDTA-plasma of 137 patients suffering from rh...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:There are only few reports on total gastrectomy by a laparoscopic surgical approach. One explanation is the fear of complications due to anastomotic dehiscence in oesophagojejunal anastomosis known to carry high morbidity and mortality. The introduction of staplers have contributed to making anastomosis safe...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND/AIM:Lipitor is a cholesterol-lowering drug and Celebrex is a Cyclooxygenase-2 inhibitor. We investigated the effects of Lipitor and Celebrex on human prostate cancer VCaP cells cultured in vitro and grown as orthotopic xenograft tumors in SCID mice. MATERIALS AND METHODS:Apoptosis was measured by morphologi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：:Multiple components in cigarette smoke were analyzed for their ability to form active oxygen species using a spin trapping agent, 5, 5-dimethyl-1-pyrroline-N-oxide. The main source of O2 and H2O2 was ascribed to polyphenols in a particulate phase, whereas a synergistic effect was also observed between these polyphenol...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Few investigators have focused on possible interactions among several MMPs collectively. MATERIALS AND METHODS:Immunostaining for MMP-7, MMP-2 and MT1-MMP was performed on 51 early invasive (T1) colorectal carcinomas, and correlations between the expressions of pairs of MMPs were examined. RESULTS:MMP-7 ex...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:12-O-retinoylphorbol-13-acetate (RPA), an incomplete tumor promoter of the phorbol ester type and protein kinase C (PKC) activator, consists of two characteristic structural elements: the phorbol body and the retinoyl ester chain. Therefore, possible binding of the incomplete tumor promoter RPA to the human transport ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND/AIM:Silencing mediator of retinoid and thyroid receptors (SMRT) is a nuclear corepressor in thyroid and estrogen hormones pathways. The aim was to evaluate SMRT expression in relation to thyroid hormone levels and prognostic markers in breast cancer (BC). PATIENTS AND METHODS:Serum and tumor tissues were ob...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14663
更新日期：2020-11-01 00:00:00
abstract：:Prophylactic cranial irradiation (PCI) is still an open question despite the fact that ten randomized trials have been published in the past, addressing its impact on overall survival, disease-free survival and incidence of brain recurrences. The majority of these trials allow us to conclude that PCI is only useful in...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：AIM:To compare a new-generation fecal immunochemical test (FIT) with the leading guaiac-based test in detection of fecal occult blood (FOB) in colonoscopy-referral patients. PATIENTS AND METHODS:A cohort of 300 patients referred for colonoscopy was examined by two different tests for FOB: ColonView quick test (CV) (FI...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Vasculogenic mimicry (VM) refers to the process in which highly invasive cancer cells mimic endothelial cells by forming blood channels. In the present study, we investigated the effect of curcumin, a natural product from turmeric, on VM of SK-Hep-1 human hepatocellular carcinoma (HCC) cells. MATERIALS AND ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-04-01 00:00:00
abstract：:Therapy of patients with metastatic renal cell carcinoma (mRCC) requires sequential use of several agents with different mechanisms and minimal cross-resistance between the different agents. Tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors prolong progression-free survival (PFS) in...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：:Human primary breast cancers were analysed for somatic loss of heterozygosity (LOH) at chromosome 18 with 15 polymorphic microsatellite markers. LOH was observed in 148 of the 228 cases analyzed, (65%). Three smallest common deletion regions (SCDR) were detected on the long arm of chromosome 18. The marker D18S51 at t...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:Carbon ion radiotherapy has precise dose distribution and high biological effectiveness and is likely a promising therapy for patients with sarcomas. We evaluated the outcomes of carbon ion radiotherapy in patients with unresectable chondrosarcomas. PATIENTS AND METHODS:A retrospective analysis of 75 tumors...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12162
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Infiltrates of lymphocytes are found in both autoimmune thyroid disease and papillary cancer and are responsible for thyroid destruction in autoimmune disease. Their role in neoplastic transformation is not yet clear. MATERIALS AND METHODS:Phenotypic studies and the capacity to undergo apoptosis were assess...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
abstract：AIM:The current study reports the type of salvage chemotherapy following osimertinib and its treatment efficacy in patients with non-small-cell lung carcinoma (NSCLC) who acquire resistance to osimertinib. PATIENTS AND METHODS:In this retrospective cohort study, data from the medical charts of 40 patients with NSCLC t...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14186
更新日期：2020-04-01 00:00:00
abstract：:In spite of endoscopic surveillance programs, 90% of patients initially presenting with Barrett's carcinoma have locally advanced disease. In these patients, preoperative chemotherapy increases the chance of a curative resection in responding patients. Unfortunately, response occurs in only 50% of patients after chemo...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2010-04-01 00:00:00
abstract：:Adenomatoid odontogenic tumour (AOT) is a benign tumour of odontogenic origin. The differential diagnosis of AOT is crucial in terms of surgical management. The 23-year old male patient presented in this case study was referred to the maxillofacial surgery clinic due to the incidental radiological finding of a large o...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Phytoestrogens are known to prevent tumor induction. But their molecular mechanisms of action are largely unknown. This study aimed to examine the effect of genistein and quercetin on proliferation and apoptosis in HER2-expressing breast cancer cells. MATERIALS AND METHODS:The antiproliferative effects of p...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Although paclitaxel was given triweekly in phase II trials prior to its approval for gastric cancer in Japan, it is currently more often delivered by a weekly schedule in the second-line setting. PATIENTS AND METHODS:A phase II trial with response rate as the primary end-point was conducted. Patients with m...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：:Sentinel lymph node biopsy (SLNB) is currently the suggested axillary staging procedure in patients with early-stage breast cancer (BC) and usually requires intraoperative frozen-section (FS) examination of the removed nodes. However, other techniques, such as touch imprint cytology (IC), real-time reverse transcripta...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：AIM:The American thyroid association (ATA) recommends that additional imaging procedures supplement cervical ultrasonography (US) in any patient with a basal calcitonin value above 150 pg/ml in the follow-up of medullary thyroid carcinoma (MTC). The aim of the present study was to reaffirm or challenge this cut-off for...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
