Abstract:
:Proteins and nucleic acids are able to adopt their native conformation and perform their biological role only in the presence of water with which they actively interact in a mutually modifying way. Traditionally, hydrophobic effect has been considered to be the major factor stabilizing biopolymeric structures. However, solvent reorganization around polar groups is an event thermodynamically more unfavorable than solvent reorganization around nonpolar groups. Consequently, burial of polar groups with formation of complementary solute-solute hydrogen bonds out of contact with water is an energetically favorable process that also provides a major force driving macromolecular association and folding. In contrast to nonpolar groups, polar groups may form their complementary intra- or intersolute hydrogen bonds out of contact with water only provided that an appropriate solute structure has been formed with properly positioned hydrogen bond donors and acceptors. Formation of such structures is disfavored entropically and may not be possible due to steric reasons. However, the interior of a folded protein, alpha-helices and beta-sheets, double helical nucleic acid structures, and protein-ligand interfaces all provide rigid matrices where polar groups may form their complementary hydrogen bonds. For these structures, the inward drive of polar groups represents a considerable stabilizing factor.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Chalikian TVdoi
10.1002/bip.10538subject
Has Abstractpub_date
2003-12-01 00:00:00pages
492-6issue
4eissn
0006-3525issn
1097-0282journal_volume
70pub_type
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