Abstract:
AIMS:To study the risk of childhood cancer in relation to parental occupation and related exposures. METHODS:Self reported occupational data from mothers and fathers of 3838 children with cancer and 7629 control children were analysed. Odds ratios were calculated for 31 "occupational groups" by parent, diagnostic group (leukaemia, acute lymphoblastic leukaemia (ALL), central nervous system tumours, and other cancers) and time of exposure (periconception, birth, and diagnosis). RESULTS:Findings did not support the hypothesis that occupational exposure of fathers to ionising radiation increases the risk of childhood cancer in their offspring. Specific examination of periconceptual chemical exposures showed small but statistically significant increased risks for leukaemia and ALL among children whose fathers were exposed to exhaust fumes, driving, and/or inhaled particulate hydrocarbons. In the remaining analyses, a fourfold increase in the risk of other cancers was observed among the children of fathers working with leather but based on small numbers. Both maternal and paternal exposure to textile dust was related to an increased risk of other cancers. CONCLUSION:Results failed to produce any strong evidence to link parental occupational exposures with an increased risk of childhood cancer. No relation was found for paternal periconceptual exposure to ionising radiation. The consistency of the associations observed between childhood leukaemia and paternal occupational exposure to exhaust fumes, driving, and/or inhaled particulate hydrocarbons at periconception suggest a small risk for vehicle related exhaust. However, other explanations cannot be excluded and further research into the nature of the associations is required.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
McKinney PA,Fear NT,Stockton D,UK Childhood Cancer Study Investigators.doi
10.1136/oem.60.12.901subject
Has Abstractpub_date
2003-12-01 00:00:00pages
901-9issue
12eissn
1351-0711issn
1470-7926journal_volume
60pub_type
杂志文章abstract:OBJECTIVES:Job exposure matrices (JEMs) can be constructed from expert-rated assessments, direct measurement and self-reports. This paper describes the construction of a general population JEM based on self-reported physical exposures, its ability to create homogeneous exposure groups (HEG) and the use of different exp...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105287
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:The main objective of this study was to investigate exposure-response relations between adverse musculoskeletal outcomes and ergonomic exposure variables. METHODS:A cross sectional analytical study was conducted in 11 factories from seven sectors of manufacturing industry in South Africa. Exposure to workpl...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.1.46
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:Both ambient ozone and temperature are associated with human health. However, few data are available on whether ozone modifies temperature effects. This study aims to explore whether ozone modified associations between maximum temperature and cardiovascular mortality in the USA. METHODS:The authors obtained...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2007.033878
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:To assess sensitivity and specificity of a questionnaire designed to detect neurotoxic symptoms in workers exposed to solvents and in patients with a psycho-organic syndrome. METHODS:The Swedish Q16 is a self administered questionnaire for neurotoxic symptoms. The modified German version consists of 18 ques...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.1.19
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:Meatpacking remains a hazardous and largely unexamined industry. Despite prevention efforts, laceration injuries, among others, remain high. We estimated the magnitude of associations between transient exposures such as equipment malfunction, performing an unusual work task, rushing, and occurrence of lacera...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2009.048611
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:To examine the impact of workplace injury on opioid dependence, abuse and overdose (opioid-related morbidity) and if severity of injury increases the hazard of these health effects. METHODS:We used MarketScan databases to follow injured and propensity score matched non-injured workers, both without prior op...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106535
更新日期:2020-09-01 00:00:00
abstract:AIMS:To assess the prevalence of general health status, use of sleep medication, and use of medication for cardiovascular diseases, and to study their relation to aircraft noise exposure. METHODS:These health indicators were measured by a cross-sectional survey among 11 812 respondents living within a radius of 25 km ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2002.005488
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:Diazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk. We used updated diazinon exposure and cancer incidence inform...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102728
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVES:Apparent increases in human male reproductive disorders, including low sperm production, may have occurred because of increased chemical exposure. Various glycol ether-based solvents have pronounced adverse effects on sperm production and male fertility in laboratory animals. The authors investigated the eff...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2005.023952
更新日期:2007-07-01 00:00:00
abstract::Worldwide, millions of office workers use a computer. Reports of adverse health effects due to computer use have received considerable media attention. This systematic review summarises the evidence for a relationship between the duration of work time spent using the computer and the incidence of hand-arm and neck-sho...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.2006.026468
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To determine site-specific cancer incidence among women spinning-weaving and dyeing-finishing workers in the largest flax textile factory in Lithuania. METHOD:The cancer incidence of a cohort of 3447 women workers from a flax textile factory was investigated for the period 1978-2002. All subjects were employ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2009.048058
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:We investigated the relationship between urinary metabolites of di(2-ethylhexyl) phthalate (DEHP) and reproductive hormones in workers of polyvinyl chloride (PVC) production plants. After exposure, most of the DEHP is rapidly metabolised to mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) ph...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102532
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:Introduced in the UK in 2010, the fit note was designed to address the problem of long-term sickness absence. We explored (1) associations between demographic variables and fit note receipt, 'maybe fit' use and long-term conditions, (2) whether individuals with long-term conditions receive more fit notes and...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-106035
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To investigate the sources of high concentrations of particles of < 10 microns diameter (PM10) in classrooms, observed in a previous study on childhood exposure to PM10, and to study the correlation between classroom and outdoor concentrations of mass and elements of PM10. METHODS:Measurements of PM10 were ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.7.482
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVES:To explore the use of 99technetiumm-hexamethyl propylene amine oxime single photon computed tomography (HMPAO-SPECT) of the brain as a means of detecting nervous tissue damage in divers and to determine if there is any correlation between brain image and a diver's history of diving or decompression illness (...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.4.247
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVES:The aim was to assess the association between occupational biomechanical exposure and the occurrence of radial nerve entrapment (RNE) in construction workers over a 13-year follow-up period. METHODS:A cohort of 229 707 male construction workers who participated in a national occupational health surveillance...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105311
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:Dental instruments such as the right angle or straight handpiece, air turbine, and ultrasonic scaler have the ability to produce dental aerosols containing water, saliva, microorganisms, blood, tooth particles, lubricating oil, and restorative materials. The purpose of this study was to find out whether pers...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.2.125
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVES:To describe the relation with age of risk of reported injury after a fall among women at work in two countries, the United Kingdom and Sweden, with particular emphasis on fractures, and to interpret these data. METHODS:Rates of accidents compiled under the national reporting regulations of each country duri...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.11.785
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:The study investigated the utility of unmetabolised naphthalene (Nap) and phenanthrene (Phe) in urine as surrogates for exposures to mixtures of polycyclic aromatic hydrocarbons (PAHs). METHODS:The report included workers exposed to diesel exhausts (low PAH exposure level, n = 39) as well as those exposed t...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.041418
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To investigate the differences between measurements of personal exposure to particulate air pollution and static area measurements in a group of people working close to traffic and to determine whether such differences might obscure any threshold for health effects in epidemiological studies. METHODS:Persona...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.12.790
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVES:To estimate the risk of lymphoma among farmers in Spain. METHODS:This is a multicentre case control study conducted in Spain. Cases were subjects diagnosed with lymphoma according to the World Health Organization (WHO) classification in four hospitals between 1998-2002. Hospital controls were frequency matc...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2005.024026
更新日期:2006-10-01 00:00:00
abstract:AIMS:To describe the age standardised prevalence of symptomatic osteoarthritis (OA) in a nationwide cross sectional survey of 10 412 patients in France, and their functional and work limitations. METHODS:Cases in the survey were compared with their expected counterpart by age, gender, and occupational groupings using ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.11.882
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:While several studies have reported associations of daily exposures to PM2.5 (particles less than 2.5 µm) with mortality, few studies have examined the impact of its constituents such as black carbon (BC), which is also a significant contributor to global climate change. METHODS:We assessed the association ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102184
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:To determine whether results from questionnaires, exposure measurements, and laboratory tests, commonly used in occupational health practice, can predict the presence or absence of sensitisation in workers exposed to high molecular weight (HMW) allergens. The study aims to develop and validate a diagnostic r...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.3.189
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To explore the relationship between occupations and specific occupational exposures and oesophageal cancer (OC) by histological type. METHODS:A multicentre hospital-based case-control study was conducted in two Mediterranean provinces of Spain. Occupational, sociodemographic and lifestyle information was col...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2007.037929
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:To determine cell differential counts and the number of asbestos bodies (ABs) in bronchoalveolar lavage (BAL) fluid obtained from patients with asbestosis, and to correlate the results with their survival. METHODS:The BAL cell differential counts and ABs from 91 patients with asbestosis were determined. The...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105606
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:There is growing evidence of an association between low-dose external γ-radiation and circulatory system diseases (CSDs), yet sparse data exist about an association with chronic internal uranium exposure and the role of non-radiation risk factors. We conducted a nested case-control study of French AREVA NC P...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104575
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Few studies have investigated cancer risks in carbon black workers and the findings were inconclusive. METHODS:The current study explores the mortality of a cohort of 1535 male German blue-collar workers employed at a carbon black manufacturing plant for at least one year between 1960 and 1998. Vital status...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.026526
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:The effect of indoor temperature control on summer and winter ambulatory blood pressure levels at work was studied. METHOD:Ambulatory systolic blood pressure (SBP) and diastolic blood pressure (DBP) were monitored once in summer and once in winter in 101 healthy normotensive subjects aged 28-63 years, engage...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.11.715
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVES:Standardised mortality ratios (SMRs) play an important role in the epidemiological literature, particularly in evaluations of occupational hazards. While some authors have argued that comparisons of SMRs should be avoided, many investigators find such analyses appealing particularly when data are sparse. For...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-100792
更新日期:2013-02-01 00:00:00