Hybrid integrate-and-fire model of a bursting neuron.

Abstract:

:We present a reduction of a Hodgkin-Huxley (HH)--style bursting model to a hybridized integrate-and-fire (IF) formalism based on a thorough bifurcation analysis of the neuron's dynamics. The model incorporates HH--style equations to evolve the subthreshold currents and includes IF mechanisms to characterize spike events and mediate interactions between the subthreshold and spiking currents. The hybrid IF model successfully reproduces the dynamic behavior and temporal characteristics of the full model over a wide range of activity, including bursting and tonic firing. Comparisons of timed computer simulations of the reduced model and the original model for both single neurons and moderately sized networks (n < or = 500) show that this model offers improvement in computational speed over the HH--style bursting model.

journal_name

Neural Comput

journal_title

Neural computation

authors

Breen BJ,Gerken WC,Butera RJ Jr

doi

10.1162/089976603322518768

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

2843-62

issue

12

eissn

0899-7667

issn

1530-888X

journal_volume

15

pub_type

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