Pharmacological characteristics and side effects of a new galenic formulation of propofol without soyabean oil.

Abstract:

:We compared the pharmacokinetics, pharmacodynamics and safety profile of a new galenic formulation of propofol (AM149 1%), which does not contain soyabean oil, with a standard formulation of propofol (Disoprivan 1%). In a randomised, double-blind, cross-over study, 30 healthy volunteers received a single intravenous bolus injection of 2.5 mg.kg-1 propofol. Plasma propofol levels were measured for 48 h following drug administration and evaluated according to a three-compartment model. The pharmacodynamic parameters assessed included induction and emergence times, respiratory and cardiovascular effects, and pain on injection. Patients were monitored for side effects over 48 h. Owing to a high incidence of thrombophlebitis, the study was terminated prematurely and only the data of the two parallel treatment groups (15 patients in each group) were analysed. Plasma concentrations did not differ significantly between the two formulations. Anaesthesia induction and emergence times, respiratory and cardiovascular variables showed no significant differences between the two treatment groups. Pain on injection (80 vs. 20%, p < 0.01) and thrombophlebitis (93.3 vs. 6.6%, p < 0.001) occurred more frequently with AM149 than with Disoprivan. Although both formulations had similar pharmacokinetic and pharmacodynamic profiles the new formulation is not suitable for clinical use due to the high incidence of thrombophlebitis produced.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Paul M,Dueck M,Kampe S,Fruendt H,Kasper SM

doi

10.1046/j.1365-2044.2003.03345.x

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

1056-62

issue

11

eissn

0003-2409

issn

1365-2044

pii

3345

journal_volume

58

pub_type

临床试验,杂志文章,随机对照试验
  • Use of methohexitone, fentanyl and nitrous oxide for short surgical procedures.

    abstract::An anaesthetic technique for unpremedicated patients undergoing minor surgery is described. After the administration of atropine and fentanyl, anaesthesia was induced with methohexitone and maintained with nitrous oxide supplemented when necessary by further small doses of methohexitone. This technique provided good o...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1977.tb11595.x

    authors: Goroszeniuk T,Whitwam JG,Morgan M

    更新日期:1977-02-01 00:00:00

  • Evaluation of an insulated Tuohy needle system for the placement of interscalene brachial plexus catheters.

    abstract::Major shoulder surgery can be extremely painful. Interscalene brachial plexus catheters provide excellent postoperative analgesia but are technically difficult to place. A new insulated Tuohy needle system for plexus catheterisation is now available. This prospective study examined its ease of use and the postoperativ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1046/j.1365-2044.2003.03184.x

    authors: Denny NM,Barber N,Sildown DJ

    更新日期:2003-06-01 00:00:00

  • Acute cardiac herniation after radical pleuropneumonectomy.

    abstract::Acute cardiac herniation after radical pneumonectomy is extremely rare and is associated with an immediate mortality greater than 50%. We report a patient in whom cardiac herniation produced no signs or symptoms. The heart was returned to its correct position and the pericardial defect was repaired. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1046/j.1365-2044.1999.00611.x

    authors: Self RJ,Vaughan RS

    更新日期:1999-06-01 00:00:00

  • Plasma morphine levels produced by continuous infusion in children.

    abstract::Blood samples were taken from six children aged between 10 months and 15 years, at intervals over a period of 40 hours while they were receiving continuous morphine infusions. The plasma morphine values obtained showed similar and consistent levels 15-30 minutes after starting the infusions. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb12847.x

    authors: Bray RJ,Beeton C,Hinton W,Seviour JA

    更新日期:1986-07-01 00:00:00

  • The intubating laryngeal mask. Results of a multicentre trial with experience of 500 cases.

    abstract::A multicentre trial of the use of the intubating laryngeal mask was carried out at seven centres in the United Kingdom using the same agreed protocol. Lung ventilation followed by blind tracheal intubation through the intubating laryngeal mask was attempted on 500 ASA grade 1 and 2 patients. It was possible to insert ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1365-2044.1998.00614.x

    authors: Baskett PJ,Parr MJ,Nolan JP

    更新日期:1998-12-01 00:00:00

  • Impact of postoperative nausea and vomiting in the surgical setting.

    abstract::Postoperative nausea and vomiting is one of the most common complications of inpatient and day case surgical procedures. In a climate where total cost of an illness is becoming increasingly important, postoperative nausea and vomiting is a major contributor to direct and indirect costs for both the hospital and patien...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2044.1994.tb03580.x

    authors: Hirsch J

    更新日期:1994-01-01 00:00:00

  • Interaction of vecuronium and atracurium during halothane anaesthesia in children.

    abstract::The combination of vecuronium and atracurium was studied in 60 children of ASA physical status 1 or 2. In part I, the dose-response relationships were determined in 30 children who were randomly assigned to receive a single bolus of 0.02, 0.025 or 0.03 mg kg-1 of vecuronium or 0.075, 0.01 or 0.0125 mg.kg-1 of atracuri...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1998.00259.x

    authors: Sloan MH,Bissonnette B,Lerman J

    更新日期:1998-01-01 00:00:00

  • Propofol sedation after open heart surgery. A clinical and pharmacokinetic study.

    abstract::One hundred adult patients who required mechanical ventilation after open heart surgery for coronary revascularisation were studied. All received a standard premedication and a high dose opioid anaesthetic. On arrival in the intensive care unit they were allocated randomly to receive either propofol or midazolam to ma...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1990.tb14743.x

    authors: McMurray TJ,Collier PS,Carson IW,Lyons SM,Elliott P

    更新日期:1990-04-01 00:00:00

  • Subarachnoid spread of epidural local anaesthetic following dural puncture.

    abstract::A case is described of an extensive block and hypotension which occurred after inadvertent dural puncture and subsequent epidural injection of bupivacaine. The subarachnoid spread of solution from the extradural space was confirmed radiologically. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1988.tb04155.x

    authors: Leach A,Smith GB

    更新日期:1988-08-01 00:00:00

  • Evaluation of the HemoCue for measuring intra-operative haemoglobin concentrations: a comparison with the Coulter Max-M.

    abstract::We compared haemoglobin concentration values obtained using a portable haemoglobinometer, the HemoCue, in the operating theatre with the results obtained by the Coulter Max-M in the laboratory. Haemoglobin concentrations were measured on 52 arterial blood samples obtained from 13 patients during aortic surgery, in the...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2044.1998.00328.x

    authors: Lardi AM,Hirst C,Mortimer AJ,McCollum CN

    更新日期:1998-04-01 00:00:00

  • Intracranial hypotension headache after uncomplicated caudal epidural injection.

    abstract::A caudal epidural injection was performed on a middle-aged woman for pain in her right foot. Although the procedure was uncomplicated and a good epidurogram was obtained, the patient went on to develop an orthostatic headache with generalised weakness and syncopal episodes that were treated successfully by epidural bl...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2011.06980.x

    authors: Thomas R,Thanthulage S

    更新日期:2012-04-01 00:00:00

  • Nathan Keep--William Morton's Salieri?

    abstract::Dr Nathan Cooley Keep (1800-1875) was a Boston dentist and doctor who carried our pioneering work in both dentistry and anaesthesia. He worked with William Morton before the first public demonstration of ether anaesthesia, formed the world's first anaesthetic partnership with Morton but parted company with him and lat...

    journal_title:Anaesthesia

    pub_type: 传,历史文章,杂志文章

    doi:10.1111/j.1365-2044.1995.tb04563.x

    authors: Keep P

    更新日期:1995-03-01 00:00:00

  • The effect of pre-emptive acupuncture treatment on analgesic requirements after day-case knee arthroscopy.

    abstract::The role of acupuncture analgesia in the management of postoperative pain is yet to be clearly evaluated. We conducted a prospective, double-blind, randomised controlled study to evaluate the effect of acupuncture pretreatment on the analgesic requirement after knee arthroscopy. Forty-two patients presenting for unila...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2044.1999.01030.x

    authors: Gupta S,Francis JD,Tillu AB,Sattirajah AI,Sizer J

    更新日期:1999-12-01 00:00:00

  • Accidental intravenous injection of cetrimide. A case report.

    abstract::An unusual case of cetrimide toxicity, probably the first of its kind to be recorded, is reported. It occurred after accidental intravenous injection in an infant and the management is discussed. Cardiac arrest, muscle paralysis, haemolysis and other complications were successfully treated. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1975.tb00897.x

    authors: Gode GR,Jayalakshmi TS,Kalla GN

    更新日期:1975-07-01 00:00:00

  • The emergency management of diabetes mellitus.

    abstract::Some of the acute metabolic derangements of unstable diabetes have been discussed. The management of patients undergoing surgical operations has also been considered. No problems are usually encountered in diabetic patients treated with diet alone or with oral hypoglycaemic compounds, although chlorpropamide may need ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1975.tb00900.x

    authors: Maw DS

    更新日期:1975-07-01 00:00:00

  • Evoked potential monitoring in anaesthesia and analgesia.

    abstract::Electrophysiological monitoring of selected neural pathways of the brain, brainstem, spinal cord and peripheral nervous system has become mandatory in some surgery of the nervous system where preventable neural injury can occur. Evoked potentials are relatively simple methods of testing the integrity of various aspect...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2044.2000.01120.x

    authors: Kumar A,Bhattacharya A,Makhija N

    更新日期:2000-03-01 00:00:00

  • Anaesthesia and the epileptic pateint. A review.

    abstract::A review is presented of some of the problems that may arise in association with anaesthesia for epileptic patients. There is the possibility of precipitating anticonvulsant drug toxicity. Numerous drug interactions are possible with some anticonvulsant agents, such as phenobarbitone and phenytoin, which affect hepati...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1975.tb00792.x

    authors: Evans DE

    更新日期:1975-01-01 00:00:00

  • Prediction of prolonged laryngoscopy.

    abstract::Duration of laryngoscopy must be kept as short as possible to prevent disturbances of oxygenation and ventilation. Because the factors associated with prolonged laryngoscopy are not well known, we studied 1000 patients undergoing tracheal intubation under general anaesthesia to determine the possible effects of their ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1046/j.1365-2044.2001.02084-5.x

    authors: Saghaei M,Safavi MR

    更新日期:2001-12-01 00:00:00

  • Epidural sufentanil versus intramuscular buprenorphine for postoperative analgesia. A double-blind comparative trial.

    abstract::Epidural sufentanil 50 micrograms was compared with intramuscular buprenorphine 0.3 mg for postoperative pain relief. Patients were assigned randomly to one of two treatment groups and received both an intramuscular and epidural injection, one of which was a placebo. Onset of pain relief was faster and quality of anal...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1987.tb05222.x

    authors: Donadoni R,Rolly G

    更新日期:1987-11-01 00:00:00

  • Pharyngeal abscess presenting with upper airway obstruction and atlanto-axial subluxation in a small infant.

    abstract::We describe an infant who presented with a combination of upper airway obstruction and atlanto-axial subluxation, secondary to a pharyngeal abscess resulting from cosmetic ear piercing. This combination posed a number of difficulties for the anasthetist and a detailed plan was formulated to prepare the child for anast...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1046/j.1365-2044.2000.01278.x

    authors: Brookes A,Moriarty A

    更新日期:2000-05-01 00:00:00

  • Continuous infusion vs. intermittent bolus injection of furosemide in acute decompensated heart failure: systematic review and meta-analysis of randomised controlled trials.

    abstract::Loop diuretics remain a fundamental pharmacological therapy to remove excess fluid and improve symptom control in acute decompensated heart failure. Several recent randomised controlled trials have examined the clinical benefit of continuous vs. bolus furosemide in acute decompensated heart failure, but have reported ...

    journal_title:Anaesthesia

    pub_type: 杂志文章,meta分析

    doi:10.1111/anae.14038

    authors: Ng KT,Yap JLL

    更新日期:2018-02-01 00:00:00

  • Spinal narcotics and central nervous system depression.

    abstract::A case of central nervous system depression which developed 7 hours after an intrathecal injection of 4 mg of morphine is described. The patient lapsed into coma with bradypnoea and "pin-point' pupils and there was no response to naloxone 0.4 mg. Treatment was continued for 3 hours. No postoperative analgesics were re...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1981.tb08679.x

    authors: Sidi A,Davidson JT,Behar M,Olshwang D

    更新日期:1981-11-01 00:00:00

  • Placement of coiled catheters into the paravertebral space.

    abstract::There are conflicting results with regard to the use of catheter-based techniques for continuous paravertebral block. Local anaesthetic spread within the paravertebral space is limited and the clinical effect is often variable. Discrepancies between needle tip position and final catheter position can also be problemat...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2011.06988.x

    authors: Luyet C,Meyer C,Herrmann G,Hatch GM,Ross S,Eichenberger U

    更新日期:2012-03-01 00:00:00

  • Haemodynamic effects of intravenous nimodipine following aneurysmal subarachnoid haemorrhage: implications for monitoring.

    abstract::Nimodipine is widely used in patients with aneurysmal subarachnoid haemorrhage for the prevention and treatment of delayed ischaemic neurological deficits. Intravenous nimodipine has significant vasodilatory properties and may compromise the achievement of haemodynamic targets in patients who receive hypertensive hype...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2044.1997.112-az0105.x

    authors: Radhakrishnan D,Menon DK

    更新日期:1997-05-01 00:00:00

  • Anaesthesia for separation of conjoined twins.

    abstract::Anaesthetic procedures for successful separation of pygopagus twins are described. A bony union in the sacral region and communication of the subarachnoid space in this region were the main abnormalities. Various anaesthetic problems during the operation and in the immediate postoperative period are discussed. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1984.tb06436.x

    authors: Roy M

    更新日期:1984-12-01 00:00:00

  • Evaluation of cardiac output in intensive care using a non-invasive arterial pulse contour technique (Nexfin(®)) compared with echocardiography.

    abstract::In this prospective study, cardiac output was measured in 38 intensive care unit patients before and after a fluid challenge, using both pulse contour analysis (Nexfin(®); BMEYE, Amsterdam, the Netherlands) and transthoracic echocardiography. The ability of the Nexfin device to detect significant changes in the veloci...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.12341

    authors: Taton O,Fagnoul D,De Backer D,Vincent JL

    更新日期:2013-09-01 00:00:00

  • Exposure of nitrous oxide to X-rays. Production of nitric oxide and nitrogen dioxide.

    abstract::X-radiation has been shown to produce nitric oxide (NO) and nitrogen dioxide (NO2) in the presence of nitrous oxide (N2O). The purpose of the present study was to confirm how much NO and NO2 was produced when constant amounts of nitrous oxide were exposed to constant X-radiation. Twenty polyethylene bottles (capacity ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1980.tb05073.x

    authors: Yanagida H,Nakajima M

    更新日期:1980-12-01 00:00:00

  • Failed extradural anaesthesia for caesarean section. Complication of subsequent spinal block.

    abstract::Two cases of unexpected high spinal anaesthesia following failed extradural anaesthesia for Caesarean section are described. In both cases rapid and unexpected advance of blockade, after the subarachnoid injection of moderate doses of local anaesthetic, required tracheal intubation. In one of the cases 15 ml of 0.9% s...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1992.tb02393.x

    authors: Beck GN,Griffiths AG

    更新日期:1992-08-01 00:00:00

  • Calculating the probability of random sampling for continuous variables in submitted or published randomised controlled trials.

    abstract::In a previous paper, one of the authors (JBC) used a chi-squared method to analyse the means (SD) of baseline variables, such as height or weight, from randomised controlled trials by Fujii et al., concluding that the probabilities that the reported distributions arose by chance were infinitesimally small. Subsequent ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.13126

    authors: Carlisle JB,Dexter F,Pandit JJ,Shafer SL,Yentis SM

    更新日期:2015-07-01 00:00:00

  • Suxamethonium induced myalgia and the effect of pre-operative administration of oral aspirin. A comparison with a standard treatment and an untreated group.

    abstract::Eighty-four fit, unpremedicated patients who presented for routine surgery and received a standard anaesthetic technique were allocated randomly to three equal groups. Group 1 received tubocurarine 0.05 mg/kg before induction of anaesthesia. Group 2 received soluble aspirin 600 mg orally one hour before surgery, while...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1988.tb06689.x

    authors: McLoughlin C,Nesbitt GA,Howe JP

    更新日期:1988-07-01 00:00:00