Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX.

Abstract:

:We report the first clinical PET study using [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine ([11C]MPDX) for imaging adenosine A1 receptors in the human brain. The binding of [11C]MPDX evaluated quantitatively as the distribution volume by a graphical analysis was high in the striatum and thalamus, and low in the cerebellum. The distribution pattern of [11C]MPDX was coincident with that of adenosine A1 receptors in vitro reported previously, and was different from those of blood flow and [18F]FDG. The [11C]MPDX PET has the potential for mapping adenosine A1 receptors in the human brain.

journal_name

Ann Nucl Med

authors

Fukumitsu N,Ishii K,Kimura Y,Oda K,Sasaki T,Mori Y,Ishiwata K

doi

10.1007/BF03006445

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

511-5

issue

6

eissn

0914-7187

issn

1864-6433

journal_volume

17

pub_type

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