Abstract:
:Small pulmonary nodules are a common radiographic finding that presents an important diagnostic challenge in contemporary medicine. While pulmonary nodules are the major radiographic indicator of lung cancer, they may also be signs of a variety of benign conditions. Measurement of nodule growth rate over time has been shown to be the most promising tool in distinguishing malignant from nonmalignant pulmonary nodules. In this paper, we describe three-dimensional (3-D) methods for the segmentation, analysis, and characterization of small pulmonary nodules imaged using computed tomography (CT). Methods for the isotropic resampling of anisotropic CT data are discussed. 3-D intensity and morphology-based segmentation algorithms are discussed for several classes of nodules. New models and methods for volumetric growth characterization based on longitudinal CT studies are developed. The results of segmentation and growth characterization methods based on in vivo studies are described. The methods presented are promising in their ability to distinguish malignant from nonmalignant pulmonary nodules and represent the first such system in clinical use.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Kostis WJ,Reeves AP,Yankelevitz DF,Henschke CIdoi
10.1109/TMI.2003.817785subject
Has Abstractpub_date
2003-10-01 00:00:00pages
1259-74issue
10eissn
0278-0062issn
1558-254Xjournal_volume
22pub_type
杂志文章abstract::The authors describe a technique to reduce truncation artifacts in chemical shift images taken for in vivo magnetic resonance spectroscopy by using boundary information available from anatomic images. In this approach, high spatial frequency components are extrapolated from the observed data by making use of the bound...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.97578
更新日期:1991-01-01 00:00:00
abstract::Studies reported in the literature indicate that breast cancer risk is associated with mammographic densities. An objective, repeatable, and a quantitative measure of risk derived from mammographic densities will be of considerable use in recommending alternative screening paradigms and/or preventive measures. However...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.938247
更新日期:2001-08-01 00:00:00
abstract::Computed tomography (CT) has become the new reference standard for quantification of emphysema. The most popular measure of emphysema derived from CT is the pixel index (PI), which expresses the fraction of the lung volume with abnormally low intensity values. As PI is calculated from a single, fixed threshold on inte...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2006.871545
更新日期:2006-04-01 00:00:00
abstract::A technique determines the optimal window width for orbiting rod transmission studies in positron emission tomography (PET). Windowing reduces noise in orbiting rod transmission studies. Lines-of-response (LOR) which intersect the rods generate primarily true coincidence events. LOR which pass far from the rods genera...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.387708
更新日期:1995-01-01 00:00:00
abstract::Iterative maximum likelihood (ML) transmission computed tomography algorithms have distinct advantages over Fourier-based reconstruction, but unfortunately require increased computation time. The convex algorithm [1] is a relatively fast iterative ML algorithm but it is nevertheless too slow for many applications. The...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.746730
更新日期:1998-12-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) provides a window on the human brain at work. Spontaneous brain activity measured during resting-state has already provided many insights into brain function. In particular, recent interest in dynamic interactions between brain regions has increased the need for more advanc...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2017.2755369
更新日期:2018-01-01 00:00:00
abstract::Spine-related disorders are amongst the most frequently encountered problems in clinical medicine. For several applications such as 1) to improve the assessment of the strength of the spine, as well as 2) to optimize the personalization of spinal interventions, image-based biomechanical modeling of the vertebrae is ex...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2387114
更新日期:2015-08-01 00:00:00
abstract::A good statistical model of speckle formation is useful for designing a good adaptive filter for speckle reduction In ultrasound B-scan images. Previously, statistical models have been used, but they failed to account for the log compression of the echo envelope employed by clinical ultrasound systems. Log-compression...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.544498
更新日期:1996-01-01 00:00:00
abstract::We describe a new approach to the problem of collimator optimization in nuclear medicine; our methodology is illustrated for the challenging case of gallium-67 imaging. Collimator-design methods based on empirical rules, such as specification of an allowable level of single-septal penetration (SSP) at a fixed energy, ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2005.857211
更新日期:2005-10-01 00:00:00
abstract::The response characteristics of two tomographic systems were compared for imaging of positron emitters: a) a SPECT system with a 3/8 in crystal and 511 keV detector shielding, equipped with a specially designed 511 keV collimator, and b) a PET V system using coincidence detection. SPECT transverse plane resolution was...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.1986.4307776
更新日期:1986-01-01 00:00:00
abstract::We present a common framework, for registering images to an atlas and for forming an unbiased atlas, that tolerates the presence of pathologies such as tumors and traumatic brain injury lesions. This common framework is particularly useful when a sufficient number of protocol-matched scans from healthy subjects cannot...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2015.2448556
更新日期:2015-12-01 00:00:00
abstract::The most frequent extracranial solid tumors of childhood, named peripheral neuroblastic tumors (pNTs), are very challenging to diagnose due to their diversified categories and varying forms. Auxiliary diagnosis methods of such pediatric malignant cancers are highly needed to provide pathologists assistance and reduce ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2020.3027547
更新日期:2021-01-01 00:00:00
abstract::In magnetic resonance imaging, spatial localization is usually achieved using Fourier encoding which is realized by applying a magnetic field gradient along the dimension of interest to create a linear correspondence between the resonance frequency and spatial location following the Larmor equation. In the presence of...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.712126
更新日期:1998-06-01 00:00:00
abstract::An automatic method has been developed for segmentation of abdominal computed tomography (CT) images for virtual colonoscopy obtained after a bowel preparation of a low-residue diet with ingested contrast solutions to enhance the image intensities of residual colonic materials. Removal of the enhanced materials was pe...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.897814
更新日期:2000-12-01 00:00:00
abstract::Magnetic resonance parameter mapping (e.g., T1 mapping, T2 mapping, T*2 mapping) is a valuable tool for tissue characterization. However, its practical utility has been limited due to long data acquisition time. This paper addresses this problem with a new model-based parameter mapping method. The proposed method util...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2322815
更新日期:2014-09-01 00:00:00
abstract::A novel image reconstruction algorithm has been developed and demonstrated for fluorescence-enhanced frequency-domain photon migration (FDPM) tomography from measurements of area illumination with modulated excitation light and area collection of emitted fluorescence light using a gain modulated image-intensified char...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/tmi.2004.839359
更新日期:2005-02-01 00:00:00
abstract::Image guided interventions have seen growing interest in recent years. The use of X-rays for the procedure impels limiting the dose over time. Image sequences obtained thereby exhibit high levels of noise and very low contrasts. Hence, the development of efficient methods to enable optimal visualization of these seque...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2014.2349034
更新日期:2015-01-01 00:00:00
abstract::An automated method is reported for segmenting 3-D fluid-associated abnormalities in the retina, so-called symptomatic exudate-associated derangements (SEAD), from 3-D OCT retinal images of subjects suffering from exudative age-related macular degeneration. In the first stage of a two-stage approach, retinal layers ar...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2012.2191302
更新日期:2012-08-01 00:00:00
abstract::Micro-computed tomography (micro-CT) has been widely used to generate high-resolution 3-D tissue images from small animals nondestructively, especially for mineralized skeletal tissues. However, its application to the analysis of soft cardiovascular tissues has been limited by poor inter-tissue contrast. Recent ex viv...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2012.2209183
更新日期:2013-01-01 00:00:00
abstract::Sulcal fundi are 3-D curves that lie in the depths of the cerebral cortex and, in addition to their intrinsic value in brain research, are often used as landmarks for downstream computations in brain imaging. In this paper, we present a geometric algorithm that automatically extracts the sulcal fundi from magnetic res...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2006.886810
更新日期:2007-04-01 00:00:00
abstract::It is well known that the inverse radon transform exists in two forms for odd and even dimension functions, respectively. This note shows that these formulas become zero when the dimension requirement is violated, which results in a simple unified formula for the inverse radon transform of arbitrary dimensions. ...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.476117
更新日期:1995-01-01 00:00:00
abstract::A new class of acquisition schemes for helical cone-beam computed tomography (CB-CT) scanning is introduced, and their effect on the reconstruction methods is analyzed. These acquisition schemes are based on a new detector shape that is bounded by the helix. It will be shown that the data acquired with these schemes a...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/42.887834
更新日期:2000-09-01 00:00:00
abstract::An automatic system is presented to find the location of the major anatomical structures in color fundus photographs; the optic disc, the macula, and the vascular arch. These structures are found by fitting a single point-distribution-model to the image, that contains points on each structure. The method can handle op...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2006.885336
更新日期:2007-01-01 00:00:00
abstract::This paper establishes for the first time that a coupled ultrasound (US) and electrical impedance tomography (EIT) system can serve as a non-invasive, spatially localized approach to extract clinically relevant muscle properties. The US/EIT system represents a potential enhancement to electrical impedance myography (E...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2018.2886152
更新日期:2019-06-01 00:00:00
abstract::3D Statistical Shape Models (3D-SSM) are widely used for medical image segmentation. However, during segmentation, they typically perform a very limited unidirectional search for suitable landmark positions in the image, relying on weak learners or use-case specific appearance models that solely take local image infor...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2016.2600502
更新日期:2017-01-01 00:00:00
abstract::This paper investigates the problem of atlas registration of brain images with gliomas. Multiparametric imaging modalities (T1, T1-CE, T2, and FLAIR) are first utilized for segmentations of different tissues, and to compute the posterior probability map (PBM) of membership to each tissue class, using supervised learni...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2010.2078833
更新日期:2011-02-01 00:00:00
abstract::We consider 3-D brain structures as continuous parameterized surfaces and present a metric for their comparisons that is invariant to the way they are parameterized. Past comparisons of such surfaces involve either volume deformations or nonrigid matching under fixed parameterizations of surfaces. We propose a new mat...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2010.2099130
更新日期:2011-03-01 00:00:00
abstract::In waveform design for magnetic resonance applications, periodic continuous-wave excitation offers potential advantages that remain largely unexplored because of a lack of understanding of the Bloch equation with periodic continuous-wave excitations. Using harmonic balancing techniques the steady state solutions of th...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2015.2423313
更新日期:2015-10-01 00:00:00
abstract::Magnetic resonance imaging (MRI) pulse sequence consoles typically employ closed proprietary hardware, software, and interfaces, making difficult any adaptation for innovative experimental technology. Yet MRI systems research is trending to higher channel count receivers, transmitters, gradient/shims, and unique inter...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2011.2169681
更新日期:2012-02-01 00:00:00
abstract::Radio-frequency current density imaging (RF-CDI) is an imaging technique that noninvasively measures current density distribution at the Larmor frequency utilizing magnetic resonance imaging (MRI). Previously implemented RF-CDI techniques were only able to image a single slice transverse to the static magnetic field B...
journal_title:IEEE transactions on medical imaging
pub_type: 杂志文章
doi:10.1109/TMI.2008.2012161
更新日期:2009-07-01 00:00:00