Mixed lymphocyte reaction and graft survival in forty cadaveric renal transplants.

abstract：:Dysfunction of T cells is a common feature in chronic persistent viral infections, including hepatitis C virus (HCV), and although hepatic and peripheral T cells have been studied extensively in chronic HCV hepatitis, the role of splenic T cell responses in such patients is poorly defined. This is an important issue, ...

journal_title：Clinical and experimental immunology

authors： Hashimoto N,Shimoda S,Kawanaka H,Tsuneyama K,Uehara H,Akahoshi T,Kinjo N,Taketomi A,Shirabe K,Akashi K,Lleo A,Ansari AA,Gershwin ME,Maehara Y

更新日期：2011-08-01 00:00:00

abstract：:Supernatants of concanavalin A (Con A)-activated human spleen cells have been previously shown to inhibit polyclonal immunoglobulin (Ig) biosynthesis by pokeweed mitogen (PWM)-stimulated human spleen and peripheral blood mononuclear cells. In the present study, hydrocortisone was added at the beginning of in vitro cul...

journal_title：Clinical and experimental immunology

authors： Ilfeld D,Krakauer RS

更新日期：1982-04-01 00:00:00

abstract：:To investigate the possible role of IL-6 in the activation of the autoimmune process in systemic lupus erythematosus (SLE), we serially measured concentrations of IL-6, IgG, and anti-dsDNA antibodies before and during exacerbations in patients with SLE. In addition, we serially related the IL-6 response to the generat...

journal_title：Clinical and experimental immunology

authors： Spronk PE,ter Borg EJ,Limburg PC,Kallenberg CG

更新日期：1992-10-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DPIV), a T cell enzyme, has been implicated in the regulation of lymphocyte proliferation in response to lectins and allogeneic cells. A sensitive fluorimetric assay has been established for the enzyme and used to investigate DPIV activity, kinetics and the subcellular localization in lymphocy...

journal_title：Clinical and experimental immunology

authors： Harland C,Shah T,Webster AD,Peters TJ

更新日期：1988-11-01 00:00:00

abstract：:Human gut-associated immunoregulatory events were studied in a pokeweed mitogen (PWM)-stimulated culture system using lymphocytes obtained from the mesenteric lymph nodes (MLN) of female subjects undergoing gastroplasty for obesity. Compared with peripheral blood lymphocytes, lymphocytes obtained from MLN secreted IgG...

journal_title：Clinical and experimental immunology

authors： Pang G,Yeung S,Clancy RL,Cripps AW,Hennessy EJ,Santhanam AN

更新日期：1986-04-01 00:00:00

abstract：:There are few studies assessing the pathogenicity of human monoclonal anti-DNA antibodies. The use of SCID mice avoids the problem of rejection of the human hybridoma cells thus allowing in vivo assessment of human immunoglobulins. Using electron microscopy we have shown that the human IgG anti-dsDNA monoclonal antibo...

journal_title：Clinical and experimental immunology

authors： Mason LJ,Ravirajan CT,Latchman DS,Isenberg DA

更新日期：2001-10-01 00:00:00

abstract：:In this paper we describe the clinical and molecular features of a new case (GOR) of homozygous human TAP2 deficiency, analysing the phenotype and function of NK cells. The patient presented from infancy with recurrent sinopulmonary infections; a selective IgG2 deficiency, negative antibody response to polysaccharide ...

journal_title：Clinical and experimental immunology

authors： Matamoros N,Milà J,Llano M,Balas A,Vicario JL,Pons J,Crespí C,Martinez N,Iglesias-Alzueta J,López-Botet M

更新日期：2001-08-01 00:00:00

abstract：:By using a flow cytometric technique which allows direct identification of proliferating cells within mixed cell populations, we have previously described that soluble extracts obtained from Mycobacterium tuberculosis or M. avium represent strong stimuli for human gammadelta+ T cells. In the present study, we demonstr...

journal_title：Clinical and experimental immunology

authors： Batoni G,Esin S,Harris RA,Källenius G,Svenson SB,Andersson R,Campa M,Wigzell H

更新日期：1998-04-01 00:00:00

abstract：:A growing body of evidence points to autophagy as an essential component in the immune response to tuberculosis. Autophagy is a direct mechanism of killing intracellular Mycobacterium tuberculosis and also acts as a modulator of proinflammatory cytokine secretion. In addition, autophagy plays a key role in antigen pro...

journal_title：Clinical and experimental immunology

authors： Ní Cheallaigh C,Keane J,Lavelle EC,Hope JC,Harris J

更新日期：2011-06-01 00:00:00

abstract：:The repeated administration of a monoclonal anti-Sm antibody (KSml) resulted in a significant prolongation of life in MRL-lpr/lpr lupus mice with a 50% mortality of 36 weeks compared with 18-24 weeks in the control groups. Control animals injected with APC11 (a myeloma protein of the same isotype) lived no longer than...

journal_title：Clinical and experimental immunology

authors： Brennan FM,Williams DG,Bovill D,Stocks MR,Maini RN

更新日期：1986-07-01 00:00:00

abstract：:By immunological screening of a cDNA library derived from protoscoleces of Echinococcus granulosus with IgE from patients with cystic echinococcosis (CE) and allergic manifestations, we isolated a protein identical to E. granulosus cyclophilin. The protein, named EA21, has close homology with Malassezia furfur cycloph...

journal_title：Clinical and experimental immunology

authors： Ortona E,Vaccari S,Margutti P,Delunardo F,Rigano R,Profumo E,Buttari B,Rasool O,Teggi A,Siracusano A

更新日期：2002-04-01 00:00:00

abstract：:It has earlier been reported that the human monoclonal antibody (MoAb 33G2) and polyclonal antibodies reactive with Pf332 may interfere in vitro with the erythrocytic cycle of Plasmodium falciparum at two potential target sites for protective antibodies, indicating that the antigen may constitute an important target f...

journal_title：Clinical and experimental immunology

authors： Iqbal J,Perlmann P,Greenwood BM,Berzins K

更新日期：1993-10-01 00:00:00

abstract：:Macrophage activation syndrome (MAS) is hyperinflammatory life-threatening syndrome, associated typically with high levels of serum ferritin. This is an iron storage protein including heavy (H) and light (L) subunits, categorized on their molecular weight. The H-/L subunits ratio may be different in tissues, depending...

journal_title：Clinical and experimental immunology

authors： Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Guggino G,Triolo G,Giacomelli R

更新日期：2018-02-01 00:00:00

abstract：:Delayed hypersensitivity skin reactions to tuberculin when injected alone or in mixture with antigens of M. leprae were examined in leprosy patients and in healthy controls. The tuberculin reaction was significantly inhibited in more than one half of both LL and BT patients by the soluble extract of M. leprae (leprosi...

journal_title：Clinical and experimental immunology

authors： Sengupta U,Sinha S,Ramu G,Lamb J,Ivanyi J

更新日期：1987-04-01 00:00:00

abstract：:To gain insight into possible determinants of in vivo polyclonal B cell activation seen in rheumatoid arthritis (RA), we enumerated immunoglobulin secreting cells appearing in cultures of peripheral blood mononuclear cells that were stimulated with pokeweed mitogen (PWM) or a newly described polyclonal B cell activato...

journal_title：Clinical and experimental immunology

authors： Pardo I,Carafa C,Dziarski R,Levinson AI

更新日期：1984-05-01 00:00:00

abstract：:Eighteen patients showing hypersensitivity to nitrofurantoin with symptoms like sudden fever, malaise, cough, pleuritis, leucocytosis and sometimes eosinophilia were analysed for immune reactions, i.e. lymphocyte transformation and specific antibodies. In addition, thirty-three individuals treated with the drug but wi...

journal_title：Clinical and experimental immunology

authors： Bäck O,Lidén S,Ahlstedt S

更新日期：1977-06-01 00:00:00

abstract：:Nine patients with active systemic lupus erythematosus entered a double-blind randomized trial to study the therapeutic effect of vigorous versus sham reinfusion plasmapheresis. Four of them received real plasmapheresis while five received sham reinfusion plasmapheresis. In the present communication we report the effe...

journal_title：Clinical and experimental immunology

authors： Tsokos GC,Balow JE,Huston DP,Wei N,Decker JL

更新日期：1982-05-01 00:00:00

abstract：:Intraepithelial lymphocytes (IELs) can be identified among epithelial cells in systemic mucosal tissues. Although intestinal IELs play a crucial role in mucosal immunity, their bronchial counterparts have not been well studied. The purpose of this study was to determine the immunological functions of human bronchial I...

journal_title：Clinical and experimental immunology

authors： Hirosako S,Goto E,Fujii K,Tsumori K,Hirata N,Tsumura S,Kamohara H,Kohrogi H

更新日期：2009-02-01 00:00:00

abstract：:The carcinoembryonic antigen (CEA) distribution obtained after fractionation of thirty sera of patients with gastrointestinal tumours by gel filtration in Sephadex G200 was compared with that resulting from extraction of the sera with perchloric acid. In all cases gel filtration yielded a fraction of free CEA and in t...

journal_title：Clinical and experimental immunology

authors： Kapsopoulou-Dominos K,Anderer FA

更新日期：1979-07-01 00:00:00

abstract：:In order to study T-cell function related to the production of autoimmune nephropathy, we immunized random-bred mice, homozygous athymic nude (nu/nu) mice and heterozygous hairy (nu/+) mice with human glomeruli contained in Freund's complete adjuvant. The random-bred and heterozygous hairy mice developed circulating a...

journal_title：Clinical and experimental immunology

authors： Bolton WK,Benton FR,Lobo PI

更新日期：1978-09-01 00:00:00

abstract：:Kawasaki disease (KD) is a systemic vasculitis with cardiac and noncardiac complications. Anti--endothelial cell antibodies (AECA) are found among many patients with KD. The aim of this study was to investigate the pathogenic role of AECA in KD using in vitro and in vivo experimental models. F(ab)2 fragments of IgG-AE...

journal_title：Clinical and experimental immunology

authors： Grunebaum E,Blank M,Cohen S,Afek A,Kopolovic J,Meroni PL,Youinou P,Shoenfeld Y

更新日期：2002-11-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharides, plays an important role in the innate immune response. In this study, we investigated the role of TLR4 in the development of experimental colitis with regard to the biological actions of macrophage migration inhibitory factor (MIF) using TLR4 null ((-/...

journal_title：Clinical and experimental immunology

authors： Ohkawara T,Takeda H,Nishihira J,Miyashita K,Nihiwaki M,Ishiguro Y,Takeda K,Akira S,Iwanaga T,Sugiyama T,Asaka M

更新日期：2005-09-01 00:00:00

abstract：:Autoantibodies directed against the Sm proteins of the spliceosome complex are found in approximately 25% of systemic lupus erythematosus (SLE) patients sera. To determine which regions of the Sm D polypeptide are involved in the lupus autoimmune response, binding to overlapping octapeptides of Sm D has been evaluated...

journal_title：Clinical and experimental immunology

authors： James JA,Mamula MJ,Harley JB

更新日期：1994-12-01 00:00:00

abstract：:The regulation of cytokine production and T cell proliferation by other cytokines is mandatory in mediating inflammatory responses but the full understanding is far from complete. We have previously reported increased production of IL-2 and IL-2 receptors (IL-2R) in IgA nephropathy. The present study was undertaken to...

journal_title：Clinical and experimental immunology

authors： Lai KN,Leung JC,Li PK,Lui SF

更新日期：1991-08-01 00:00:00

abstract：:Recently we reported that monocyte phagocytosis and chemotaxis are impaired in X-linked agammaglobulinaemia (XLA) and common variable immunodeficiency (CVI) patients. Few data exist on the in vivo expression of receptors for the constant region of immunoglobulin (IgG) (Fc gammaR) and complement receptors (CR) in these...

journal_title：Clinical and experimental immunology

authors： Amoras AL,da Silva MT,Zollner RL,Kanegane H,Miyawaki T,Vilela MM

更新日期：2007-12-01 00:00:00

abstract：:Serum IgG-antilipoprotein-autoantibody activity (at 4 degrees C) of a plane xanthoma patient was shown by double-immunodiffusion method. Cryoglobulins in the serum were dissociated to polyclonal IgG and alpha- and beta-lipoproteins by acidification and were reconstructed by neutralization. IgG fraction of the cryoglob...

journal_title：Clinical and experimental immunology

authors： Kodama H

更新日期：1977-06-01 00:00:00

abstract：:Individuals with a negative intradermal reaction to tuberculin PPD have long been described in the Mycobacterium tuberculosis exposed, immune-competent population. Here, we studied PPD-specific blood T lymphocytes from these subjects for phenotypic markers relevant to skin migration, including the expression of the sk...

journal_title：Clinical and experimental immunology

authors： Magnani ZI,Confetti C,Besozzi G,Codecasa LR,Panina-Bordignon P,Lang R,Rossi GA,Pardi R,Burastero SE

更新日期：2000-01-01 00:00:00

abstract：:Cellular immune responses against the oncoantigen anaplastic lymphoma kinase (ALK) in patients with ALK-positive anaplastic large cell lymphoma (ALCL) have been detected using peptide-based approaches in individuals preselected for human leucocyte antigen (HLA)-A*02:01. In this study, we aimed to evaluate nucleophosmi...

journal_title：Clinical and experimental immunology

authors： K Singh V,Werner S,Hackstein H,Lennerz V,Reiter A,Wölfel T,Damm-Welk C,Woessmann W

更新日期：2016-10-01 00:00:00

abstract：:The effect of various exogenous cells on the in-vitro PWM stimulation of immunoglobulin synthesis by normal human peripheral blood mononuclear cells was investigated. The accessory cells tested were bovine and human endothelial cells, bovine and human fibroblasts, normal human monocytes, and a monocyte cell line U937....

journal_title：Clinical and experimental immunology

authors： King MA,Roche WR,Nelson DS

更新日期：1986-09-01 00:00:00

abstract：:Aspergillus fumigatus, a ubiquitous fungus, is implicated in the pathogenesis of a number of clinically different allergic diseases in man, including allergic bronchopulmonary aspergillosis. Peptide-based immunotherapy may offer an alternative treatment strategy for the management of allergic disease. The objective of...

journal_title：Clinical and experimental immunology

authors： Svirshchevskaya EV,Alekseeva L,Marchenko A,Viskova N,Andronova TM,Benevolenskii SV,Kurup VP

更新日期：2002-02-01 00:00:00