Abstract:
:An immunoenzymometric assay (IEMA) for a new CA125-like antigen, CA602, was developed. Five monoclonal antibodies raised against a human ovarian carcinoma cell line could detect their respective antigens in the sera of ovarian carcinoma patients. The antigen levels detected in serum by the various antibodies correlated significantly to each other, and to CA125 levels. The results of epitope analyses and combined IEMAs suggested that the epitopes recognized by these antibodies are not same, but exist on the same antigen which bears the CA125 epitope. A sensitive IEMA was developed with 602-1 and 602-6 antibodies which showed high reactivity to the CA125-like antigen. The antigen defined by these two antibodies was designated as CA602, and serum CA602 levels correlated well with CA125 levels. The CA602 antigen is a CA125-like antigen. Furthermore, the serum CA602 levels did not correlate to CA54/61 levels. The combined assays of CA602 and CA54/61 may increase the detection of ovarian carcinoma.
journal_name
J Clin Lab Analjournal_title
Journal of clinical laboratory analysisauthors
Mochizuki H,Sato I,Nagoya K,Furusako S,Yamauchi T,Masuko H,Sato H,Morishita H,Yajima M,Sasaki Hdoi
10.1002/jcla.1860060204subject
Has Abstract,Author List Incompletepub_date
1992-01-01 00:00:00pages
84-90issue
2eissn
0887-8013issn
1098-2825journal_volume
6pub_type
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journal_title:Journal of clinical laboratory analysis
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journal_title:Journal of clinical laboratory analysis
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