Variable region cDNA sequences of three mouse monoclonal anti-idiotypic antibodies specific for anti-alpha(1----6)dextrans with groove- or cavity-type combining sites.

Abstract:

:The variables regions of three syngeneic anti-idiotypic antibodies (Ab2s) were cloned and sequenced. They are encoded by different VL genes, two are from different members of V kappa-Ox1 superfamily. The H chains are encoded by VH genes belonging to three different VH families, J558, Q52 and 7183. Together with a previous report from this laboratory, the nucleotide sequences of four Ab2s to anti-alpha(1----6)dextrans have been presented. They are derived from a number of unrelated germline genes, and differ from similar studies in anti-NP, anti-GAT and anti-Ars systems. Three of four Ab2s in the anti-alpha(1----6)dextran system appear to have D-D fusions, which has also been reported in several other Ab2s.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Chen J,Borden P,Liao J,Kabat EA

doi

10.1016/0161-5890(92)90045-y

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

1121-9

issue

9

eissn

0161-5890

issn

1872-9142

journal_volume

29

pub_type

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