Abstract:
:The variables regions of three syngeneic anti-idiotypic antibodies (Ab2s) were cloned and sequenced. They are encoded by different VL genes, two are from different members of V kappa-Ox1 superfamily. The H chains are encoded by VH genes belonging to three different VH families, J558, Q52 and 7183. Together with a previous report from this laboratory, the nucleotide sequences of four Ab2s to anti-alpha(1----6)dextrans have been presented. They are derived from a number of unrelated germline genes, and differ from similar studies in anti-NP, anti-GAT and anti-Ars systems. Three of four Ab2s in the anti-alpha(1----6)dextran system appear to have D-D fusions, which has also been reported in several other Ab2s.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Chen J,Borden P,Liao J,Kabat EAdoi
10.1016/0161-5890(92)90045-ysubject
Has Abstractpub_date
1992-09-01 00:00:00pages
1121-9issue
9eissn
0161-5890issn
1872-9142journal_volume
29pub_type
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