Abstract:
:6-Amino-6-deoxyfumagillol (5) was synthesized by reductive amination of 6-oxo-6-deoxyfumagillol (4), which was obtained by oxidation of fumagillol (2). The reduction proceeded stereoselectively by the equatorial attack of hydride and 5 was found to have the same stereochemistry as that of 2. Several derivatives of 5 were prepared and most of them showed anti-angiogenic activity comparable to that of fumagillol derivatives.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Marui S,Kishimoto Sdoi
10.1248/cpb.40.575subject
Has Abstractpub_date
1992-03-01 00:00:00pages
575-9issue
3eissn
0009-2363issn
1347-5223journal_volume
40pub_type
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