Abstract:
:Survivin is overexpressed in several types of haematological malignancies making it an attractive target for therapeutic cytotoxic T-lymphocyte responses. Here, we identify two peptide epitopes derived from the murine survivin protein and demonstrate that Balb/c mice treated with syngeneic dendritic cells pulsed with the survivin epitopes were able to reject an otherwise lethal tumour inoculation of the A20 lymphoma. For the first time, these data provide evidence for the use of survivin peptide epitopes in T cell-based immunotherapeutic concepts against a B-cell lymphoma in vivo.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Siegel S,Wagner A,Schmitz N,Zeis Mdoi
10.1046/j.1365-2141.2003.04535.xsubject
Has Abstractpub_date
2003-09-01 00:00:00pages
911-4issue
6eissn
0007-1048issn
1365-2141pii
4535journal_volume
122pub_type
杂志文章abstract::Umbilical cord blood is a valuable source of haemopoietic stem/progenitor cells (HSC) for transplantation. This study explored the effect of maternal plasma/human serum albumin (HSA) in the purification and culture conditions of CD34+ cells derived from human umbilical cord blood. During CD34+ cell enrichment, includi...
journal_title:British journal of haematology
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doi:10.1111/j.1365-2141.2007.06606.x
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abstract::The prognostic significance of SOCS3 protein expression was determined in de novo follicular lymphomas (FL) with t(14;18) and bcl-2 overexpression. Presentation lymph nodes from 82 FL patients for whom clinical information was available were immunohistochemically segregated into SOCS3-positive (n = 42) or -negative (n...
journal_title:British journal of haematology
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doi:10.1111/j.1365-2141.2006.06248.x
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journal_title:British journal of haematology
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doi:10.1046/j.1365-2141.2000.02043.x
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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更新日期:2004-03-01 00:00:00
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journal_title:British journal of haematology
pub_type: 杂志文章,评审
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journal_title:British journal of haematology
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abstract::Atrial fibrillation (AF) is a common cardiac arrhythmia with a 5-20% annual risk of stroke. Warfarin reduces this risk by at least 60%. Despite adequate anticoagulation within the target International Normalized Ratio (INR) range of 2.0-3.0, some patients still experience thrombotic and bleeding events. It is now poss...
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journal_title:British journal of haematology
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abstract::Anti-thymocyte globulins (ATG) are currently used to prevent graft-versus-host disease in haematopoietic stem cell transplants from alternative donors and to treat and prevent acute organ rejection after transplantation. Many recent studies have demonstrated that ATG can also be beneficial in patients with myeloma, ly...
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journal_title:British journal of haematology
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journal_title:British journal of haematology
pub_type: 杂志文章
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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