Light emitting diode irradiation protect against the amyloid beta 25-35 induced apoptosis of PC12 cell in vitro.

Abstract:

BACKGROUND AND OBJECTIVES:Whether light emitting diode (LED) irradiation has effects on "beta-amyloid (A beta) induced apoptosis," a leading hypothesis of the cause of Alzheimer's disease (AD), or not? STUDY DESIGN/MATERIALS AND METHODS:Monolayer cell cultures of PC12 were subjected to A beta or/and LED irradiation at various intensity. Cell apoptosis was confirmed by morphological criteria, DNA fragmentation assay, and FAScan flow cytometer assay. RESULTS:Treatment of the cells with LED irradiation significantly diminished A beta induced apoptosis within 24 hours. CONCLUSIONS:The LED irradiation, when utilized at power of 0.9 W/m(2) and 60 minutes has significantly diminished A beta induced apoptosis of PC12 cells.

journal_name

Lasers Surg Med

authors

Duan R,Zhu L,Liu TC,Li Y,Liu J,Jiao J,Xu X,Yao L,Liu S

doi

10.1002/lsm.10216

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

199-203

issue

3

eissn

0196-8092

issn

1096-9101

journal_volume

33

pub_type

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