A national survey of genitourinary medicine clinic attenders provides little evidence of sexual transmission of hepatitis C virus infection.

Abstract:

OBJECTIVE:To determine the prevalence and genetic diversity of hepatitis C virus in genitourinary medicine clinic attenders and to assess the extent of sexual transmission of the virus. METHODS:A cross sectional, unlinked, anonymous survey in 14 genitourinary medicine clinics situated in England, Wales, and Northern Ireland. Serum specimens from genitourinary medicine clinic attenders, retained as part of the Unlinked Anonymous Prevalence Monitoring Programme (UAPMP) serum archive, were tested in small pools, for the presence of antibody to hepatitis C virus (anti-HCV). The main outcome measures were prevalence of antibodies to hepatitis C virus and identification of hepatitis C virus genotypes. RESULTS:Testing of 17,586 specimens from 1995 showed an adjusted prevalence of anti-HCV in genitourinary medicine clinic attenders of 1.03% (95% CI: 0.89 to 1.16) overall and 0.65% (95% CI: 0.51 to 0.78) among those who did not report injecting drug use. Prevalence in injecting drug users attending genitourinary medicine clinics was 36.9% in both 1995 and 1996. Heterosexual injecting drug users had a higher prevalence of anti-HCV than homosexual/bisexual injectors. The most common hepatitis C genotypes were types 3a and 1a. There was a high degree of concordance between genotype and serotype. CONCLUSIONS:The low prevalence of anti-HCV in genitourinary medicine clinic attenders who deny injecting drugs suggests that the majority of hepatitis C infections have been acquired in adult life, mostly by injecting drug use, and that the hepatitis C virus is rarely transmitted sexually. The use of needle exchanges may explain the relatively low prevalence observed in the injecting drug users.

journal_name

Sex Transm Infect

authors

Balogun MA,Ramsay ME,Parry JV,Donovan L,Andrews NJ,Newham JA,McGarrigle C,Harris KA,Teo CG

doi

10.1136/sti.79.4.301

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

301-6

issue

4

eissn

1368-4973

issn

1472-3263

journal_volume

79

pub_type

杂志文章,多中心研究
  • Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study.

    abstract:OBJECTIVES:Sexually transmitted infections (STI) and bacterial vaginosis (BV) cause female genital tract inflammation. This inflammation, which is often present in the absence of symptoms, is associated with increased susceptibility to HIV infection. We aimed to evaluate genital cytokine profiles and the degree of infl...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2014-051601

    authors: Masson L,Mlisana K,Little F,Werner L,Mkhize NN,Ronacher K,Gamieldien H,Williamson C,Mckinnon LR,Walzl G,Abdool Karim Q,Abdool Karim SS,Passmore JA

    更新日期:2014-12-01 00:00:00

  • Trichomonas vaginalis, endometritis and sequelae among women with clinically suspected pelvic inflammatory disease.

    abstract:OBJECTIVE:To ascertain the prevalence of Trichomonas vaginalis and investigate associations between trichomoniasis, endometritis and sequelae among women with pelvic inflammatory disease (PID). METHODS:We assessed the prevalence of trichomoniasis identified via wet mount and its association with histologically confirm...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2019-054079

    authors: Wiringa AE,Ness RB,Darville T,Beigi RH,Haggerty CL

    更新日期:2020-09-01 00:00:00

  • Rapid accurate point-of-care tests combining diagnostics and antimicrobial resistance prediction for Neisseria gonorrhoeae and Mycoplasma genitalium.

    abstract::In addition to inadequate access to early diagnosis and treatment with antimicrobial agents for patients and sexual contacts, management and control of STIs is significantly challenged by emergence and spread of antimicrobial resistance (AMR), particularly for STIs such as Neisseria gonorrhoeae and Mycoplasma genitali...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2016-053072

    authors: Sadiq ST,Mazzaferri F,Unemo M

    更新日期:2017-12-01 00:00:00

  • The superiority of polymerase chain reaction over an amplified enzyme immunoassay for the detection of genital chlamydial infections.

    abstract:BACKGROUND/OBJECTIVES:The polymer conjugate enhanced enzyme immunoassay (IDEIA) and Cobas Amplicor polymerase chain reaction Chlamydia trachomatis (CT) (Amplicor PCR) are two commonly used assays for the diagnosis of CT infection. The performance of these assays was compared for the diagnosis of genital CT infection am...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2005.015362

    authors: Jalal H,Stephen H,Al-Suwaine A,Sonnex C,Carne C

    更新日期:2006-02-01 00:00:00

  • Incidence of severe reproductive tract complications associated with diagnosed genital chlamydial infection: the Uppsala Women's Cohort Study.

    abstract:OBJECTIVE:To estimate the cumulative incidence of severe complications associated with genital chlamydia infection in the general female population. METHODS:The Uppsala Women's Cohort Study was a retrospective population based cohort study in Sweden, linking laboratory, hospital, and population registers. We estimated...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2005.017186

    authors: Low N,Egger M,Sterne JA,Harbord RM,Ibrahim F,Lindblom B,Herrmann B

    更新日期:2006-06-01 00:00:00

  • Characterisation of Chlamydia trachomatis by ompA sequencing and multilocus sequence typing in a Swedish county before and after identification of the new variant.

    abstract:OBJECTIVES:In 2006 a new variant of Chlamydia trachomatis (nvCT), with a deletion in the cryptic plasmid, was reported in Sweden. This deletion included the targets for the genetic diagnostic systems used in many clinical laboratories and resulted in thousands of false-negative results. The aim of this study was to cha...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2009.037572

    authors: Jurstrand M,Christerson L,Klint M,Fredlund H,Unemo M,Herrmann B

    更新日期:2010-02-01 00:00:00

  • Sorting out the new HSV type specific antibody tests.

    abstract::This review will delineate performance characteristics and limitations, as far as they are known, of the new glycoprotein G based, type specific HSV serologies. Several of these tests have been FDA approved in the United States for use in adults. With the departure of Gull/Meridian from the HSV serology market, it is ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.77.4.232

    authors: Ashley RL

    更新日期:2001-08-01 00:00:00

  • Assisting medical students to conduct empathic conversations with patients from a sexual medicine clinic.

    abstract:OBJECTIVE:To describe an exercise, the structure and content of which assists medical students to conduct potentially embarrassing conversations concerning sexual health which require expression of empathy, to integrate previous learning, to identify their further learning needs, and to develop and test strategies to m...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.4.246

    authors: Henderson P,Johnson MH

    更新日期:2002-08-01 00:00:00

  • Homosexual men's HIV related sexual risk behaviour in Scotland.

    abstract:OBJECTIVE:To date, the epidemic of HIV infection in Scotland has been primarily associated with injecting drug use. However, the epidemiology of HIV in Scotland changed in the late 1980s, with homosexual men becoming the largest group at risk of HIV infection and AIDS. Our aim was to describe homosexual men's sexual ri...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.75.4.242

    authors: Hart GJ,Flowers P,Der GJ,Frankis JS

    更新日期:1999-08-01 00:00:00

  • High levels of unprotected anal intercourse and never testing for HIV among men who have sex with men in Nigeria: evidence from a cross-sectional survey for the need for innovative approaches to HIV prevention.

    abstract:OBJECTIVES:To describe sexual risk behaviour, correlates of unprotected anal intercourse (UAI) and never testing for HIV and its implications for HIV prevention interventions among men who have sex with men (MSM) in Nigeria and other similar contexts. METHODS:A cross-sectional survey was administered to 712 MSM in Abu...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sextrans-2013-051065

    authors: Vu L,Andrinopoulos K,Tun W,Adebajo S

    更新日期:2013-12-01 00:00:00

  • Behavioural sources of repeat Chlamydia trachomatis infections: importance of different sex partners.

    abstract:OBJECTIVE:To examine sources of repeat Chlamydia trachomatis infections using behavioural and molecular methods. METHODS:Women with C. trachomatis had baseline and 4-month follow-up visits consisting of behavioural surveys and genotyping of C. trachomatis. Frequencies and population-attributable risk percentages (PAR%...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2010.045484

    authors: Niccolai LM,Livingston KA,Laufer AS,Pettigrew MM

    更新日期:2011-04-01 00:00:00

  • Risky business: health and safety in the sex industry over a 9 year period.

    abstract:OBJECTIVES:To assess whether a previously established low sexually transmitted infection/HIV risk in prostitutes in London has been sustained, and to measure other occupational risks, including mortality. DESIGN:9 year prospective study in west London. SUBJECTS:402 prostitutes recruited from 1985 to 1991, 320 were fo...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.75.5.340

    authors: Ward H,Day S,Weber J

    更新日期:1999-10-01 00:00:00

  • Estimating the number of men who have sex with men in low and middle income countries.

    abstract:OBJECTIVES:To collect and analyse published and unpublished surveillance and research data on the prevalence of same sex sexual activity among male adults (including male-to-female transgenders and sex workers) in low and middle income countries. METHODS:Key indicators were operationalised (ever sex with a man, sex wi...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.2005.019489

    authors: Cáceres C,Konda K,Pecheny M,Chatterjee A,Lyerla R

    更新日期:2006-06-01 00:00:00

  • Prevalence, incidence and associated risk factors of STIs during pregnancy in South Africa.

    abstract:OBJECTIVE:STIs during pregnancy increase adverse pregnancy and birth outcomes and may increase HIV risk. STI syndromic management is standard of care in South Africa. Our study evaluated the prevalence and incidence of STIs in pregnant women and the associated risk factors. METHODS:We combined data from two prospectiv...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2020-054631

    authors: Nyemba DC,Medina-Marino A,Peters RPH,Klausner JD,Ngwepe P,Myer L,Johnson LF,Davey DJ

    更新日期:2020-10-01 00:00:00

  • Inferior vena cava filters for HIV infected patients with pulmonary embolism and contraindications to anticoagulation.

    abstract:OBJECTIVES:To describe the mode of presentation, interventions, and outcome of HIV infected patients with pulmonary embolism and a contraindication to anticoagulation, who were treated with a bird's nest filter. METHODS:Retrospective review of case records and imaging department database at UCL Hospitals, London, UK. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.76.5.395

    authors: Shahmanesh M,Brooks J,Shaw PJ,Miller RF

    更新日期:2000-10-01 00:00:00

  • Emergent properties of HIV risk among injection drug users in Tallinn, Estonia: synthesis of individual and neighbourhood-level factors.

    abstract:OBJECTIVES:HIV/AIDS risk is embodied within multiple levels including structural and social levels. The aim of this study was to assess the effects of neighbourhood characteristics on HIV prevalence among injection drug users (IDU) residing in the area of Tallinn, Estonia in 2007. METHODS:A cross-sectional, multilevel...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2009.040212

    authors: Uusküla A,McMahon JM,Raag M,Silm S,Rüütel K,Talu A,Abel-Ollo K,Ahas R,Des Jarlais DC

    更新日期:2010-12-01 00:00:00

  • The performance of non-NAAT point-of-care (POC) tests and rapid NAAT tests for chlamydia and gonorrhoea infections. An assessment of currently available assays.

    abstract:OBJECTIVES:To identify point-of-care (POC) and rapid nucleic acid amplification techniques (NAATs) for the diagnosis of chlamydia and gonorrhoea and assess their utility. METHODS:Literature search for available POC and rapid NAATs. The performance from the best-performing assays were applied hypothetically to patients...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sextrans-2014-051997

    authors: Brook G

    更新日期:2015-12-01 00:00:00

  • Cross-sectional survey of treatment practices for urethritis at pharmacies, private clinics and government health facilities in coastal Kenya: many missed opportunities for HIV prevention.

    abstract:BACKGROUND:While bacterial sexually transmitted infections (STIs) are important cofactors for HIV transmission, STI control has received little attention in recent years. The aim of this study was to assess STI treatment and HIV testing referral practices among health providers in Kenya. METHODS:In 2011 we assessed qu...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050979

    authors: Mugo PM,Duncan S,Mwaniki SW,Thiong'o AN,Gichuru E,Okuku HS,van der Elst EM,Smith AD,Graham SM,Sanders EJ

    更新日期:2013-11-01 00:00:00

  • The case for further treatment studies of uncomplicated genital Chlamydia trachomatis infection.

    abstract::Azithromycin 1 g immediately and doxycycline 100 mg twice daily have good antimicrobial activity against Chlamydia trachomatis and treatment studies have demonstrated a >95% microbiological cure at 2-5 weeks, with antimicrobial resistance being rarely reported. Recently an 8% (95%, CI 5% to 11%) failure rate was obser...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.2005.019158

    authors: Horner P

    更新日期:2006-08-01 00:00:00

  • British HIV Association guidelines for prescribing antiretroviral therapy in pregnancy (1998).

    abstract::The aim of antiretroviral therapy in pregnancy is to deliver a healthy uninfected child to a healthy mother, without prejudicing the future treatment opportunities of the mother. The use of zidovudine monotherapy rapidly became standard practice once it had been shown to reduce by 67% mother to child transmission in w...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.75.2.90

    authors: Taylor GP,Lyall EG,Mercey D,Smith R,Chester T,Newell ML,Tudor-Williams G

    更新日期:1999-04-01 00:00:00

  • Markers of local immunity in cervico-vaginal secretions of HIV infected women: implications for HIV shedding.

    abstract:OBJECTIVES:To link local proinflammatory cytokines with HIV related nucleic acids in cervico-vaginal secretions and the factors associated with them. METHODS:An observational study on 60 HIV positive women attending the department of obstetrics and gynaecology, University of Pavia, Italy. HIV-1 RNA in plasma, proviral...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2003.005157

    authors: Zara F,Nappi RE,Brerra R,Migliavacca R,Maserati R,Spinillo A

    更新日期:2004-04-01 00:00:00

  • Self-sampling for oropharyngeal and rectal specimens to screen for sexually transmitted infections: acceptability among men who have sex with men.

    abstract:OBJECTIVES:To explore the feasibility and acceptability of self-sampling for oropharyngeal and rectal specimens to screen for sexually transmitted infections (STIs) among men who have sex with men (MSM). Participant's willingness to self-sample at home was also explored. METHODS:Participants of a study to evaluate the...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2008.032193

    authors: Wayal S,Llewellyn C,Smith H,Hankins M,Phillips A,Richardson D,Fisher M,Home Sampling Kit Project Steering Group.

    更新日期:2009-02-01 00:00:00

  • Prevalence of sexually transmitted infections and performance of STI syndromes against aetiological diagnosis, in female sex workers of red light area in Surat, India.

    abstract:OBJECTIVES:To measure prevalence of selected sexually transmitted infections (STI) and HIV among female sex workers (SWs) in the red light area of Surat, India, and to evaluate the performance of STI syndrome guidelines (for general population women in India) in this group against the standard aetiological diagnosis of...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.79.2.111

    authors: Desai VK,Kosambiya JK,Thakor HG,Umrigar DD,Khandwala BR,Bhuyan KK

    更新日期:2003-04-01 00:00:00

  • Chancroid: clinical manifestations, diagnosis, and management.

    abstract::Chancroid is a sexually transmitted disease (STD) caused by the Gram negative bacterium Haemophilus ducreyi and is characterised by necrotising genital ulceration which may be accompanied by inguinal lymphadenitis or bubo formation. H ducreyi is a fastidious organism which is difficult to culture from genital ulcer ma...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.79.1.68

    authors: Lewis DA

    更新日期:2003-02-01 00:00:00

  • The potential role of serology in diagnosing chronic lymphogranuloma venereum (LGV): a case of LGV mimicking Crohn's disease.

    abstract::We present the case of a 26 year old HIV positive homosexual man who was managed for suspected Crohn's disease for over 1 year before lymphogranuloma venereum (LGV) was clinically diagnosed. He had presented with constipation, secondary to acute haemorrhagic proctitis, and subsequently had two chlamydia negative recta...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2005.016667

    authors: Forrester B,Pawade J,Horner P

    更新日期:2006-04-01 00:00:00

  • What is the excess risk of infertility in women after genital chlamydia infection? A systematic review of the evidence.

    abstract:OBJECTIVE:To summarise evidence on the attributable risk of infertility after chlamydial infection in women. METHODS:Twelve databases were searched, limited to peer-reviewed literature published from January 1970 to September 2007. Conference abstracts and reference lists from reviews published since 2000 and from key...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.2007.026047

    authors: Wallace LA,Scoular A,Hart G,Reid M,Wilson P,Goldberg DJ

    更新日期:2008-06-01 00:00:00

  • Patterns of chlamydia testing in different settings and implications for wider STI diagnosis and care: a probability sample survey of the British population.

    abstract:BACKGROUND:Following widespread rollout of chlamydia testing to non-specialist and community settings in the UK, many individuals receive a chlamydia test without being offered comprehensive STI and HIV testing. We assess sexual behaviour among testers in different settings with a view to understanding their need for o...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2016-052719

    authors: Clifton S,Mercer CH,Woodhall SC,Sonnenberg P,Field N,Lu L,Johnson AM,Cassell JA

    更新日期:2017-06-01 00:00:00

  • Role of widows in the heterosexual transmission of HIV in Manicaland, Zimbabwe, 1998-2003.

    abstract:BACKGROUND:AIDS is the main driver of young widowhood in southern Africa. METHODS:The demographic characteristics of widows, their reported risk behaviours and the prevalence of HIV were examined by analysing a longitudinal population-based cohort of men and women aged 15-54 years in Manicaland, eastern Zimbabwe. The ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2008.033043

    authors: Lopman BA,Nyamukapa C,Hallett TB,Mushati P,Spark-du Preez N,Kurwa F,Wambe M,Gregson S

    更新日期:2009-04-01 00:00:00

  • Improving our understanding of the disproportionate incidence of STIs in heterosexual-identifying people of black Caribbean heritage: findings from a longitudinal study of sexual health clinic attendees in England.

    abstract:OBJECTIVE:In England, people of black minority ethnicities are at elevated risk of STI diagnosis, especially those of black Caribbean (BC) heritage. Understanding the factors that predict STI acquisition in this population is key to inform prevention measures. We examined the differences in predictors of incident STI d...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2020-054784

    authors: Bardsley M,Wayal S,Blomquist P,Mohammed H,Mercer CH,Hughes G

    更新日期:2021-01-29 00:00:00

  • Sexual behaviour and early coitarche in a national sample of 17 year old Swedish girls.

    abstract:OBJECTIVE:To evaluate sexual behaviour in 17 year old girls, using data from a national survey on adolescent sexuality. METHOD:The study was based on two samples of 17 year olds, comprising 2% of the population born in 1973 and carried out in 1990. A school sample and a sample of school non-attenders were recruited in...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.76.2.98

    authors: Edgardh K

    更新日期:2000-04-01 00:00:00