Abstract:
:The focus of high-throughput drug discovery has progressed through the genome and the transcriptome and is now moving towards more difficult problems in assessing the proteome, glycome and metabolome. Microarrays are currently the major tool in the assessment of gene expression via cDNA or RNA analysis; however, they are also used to screen libraries of proteins and small molecules. Microarrays have helped to extract more information from smaller sample volumes and enabled the incorporation of low-cost high-throughput assays in the drug discovery process. The technology continues to develop and is being rapidly transferred into more challenging areas, with the potential to further aid and enhance the drug discovery process through the development of, for example, proteomic, glycomic and tissue arrays.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Howbrook DN,van der Valk AM,O'Shaughnessy MC,Sarker DK,Baker SC,Lloyd AWdoi
10.1016/s1359-6446(03)02773-9subject
Has Abstractpub_date
2003-07-15 00:00:00pages
642-51issue
14eissn
1359-6446issn
1878-5832pii
S1359644603027739journal_volume
8pub_type
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