VIP and PACAP are autocrine factors that protect the androgen-independent prostate cancer cell line PC-3 from apoptosis induced by serum withdrawal.

abstract：:1 The activation of tachykinin NK(1) receptors in the rat spinal cord produced a transient drop in arterial blood pressure followed by a more prolonged pressor effect which is mediated by the stimulation of the sympatho-adrenal system. This study aims at characterizing the spinal mechanism of that initial hypotension ...

journal_title：British journal of pharmacology

authors： Brouillette J,Couture R

更新日期：2002-08-01 00:00:00

abstract：:The releases of [3H]5-hydroxytryptamine ([3H]5-HT) and of endogenous glutamic acid and their modulation through presynaptic h5-HT1B autoreceptors and h5-HT1D heteroreceptors have been investigated in synaptosomal preparations from fresh neocortical samples obtained from patients undergoing neurosurgery. The inhibition...

journal_title：British journal of pharmacology

authors： Marcoli M,Maura G,Munari C,Ruelle A,Raiteri M

更新日期：1999-02-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) applied by ionophoresis, pressure ejection and superfusion to myenteric neurones of the guinea-pig ileum were investigated by intracellular recording techniques. Ionophoretic or pressure application of GABA (10 pC-30 nC) caused membrane depolarizations of AH neurones but n...

journal_title：British journal of pharmacology

authors： Cherubini E,North RA

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Imiquimod is an immunomodulator approved for the treatment of basal cell carcinoma and has adverse side effects, including taste disturbances. Paracrine transmission, representing cell-cell communication within taste buds, has the potential to shape the final signals that taste buds transmit to t...

journal_title：British journal of pharmacology

authors： Huang AY,Wu SY

更新日期：2016-11-01 00:00:00

abstract：:1. Histamine release by compound 48/80 was substantially reduced in a time-dependent manner (maximum at 30 min) by pre-incubating mast cells in calcium-free medium at 37 degrees C but not at 2 degrees C. This effect was optimal at pH 7.0 to 7.5. 2. The re-introduction of calcium (0.1 to 3 mmol/l) restored histamine re...

journal_title：British journal of pharmacology

authors： Garland LG,Payne AN

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intestinal mucositis is a common side-effect of irinotecan-based cancer chemotherapy regimens. This mucositis is associated with cytokine activation and NO synthesis. Production of IL-18 is up-regulated in patients suffering from inflammatory bowel disease. Therefore, we have investigated the rol...

journal_title：British journal of pharmacology

authors： Lima-Júnior RC,Freitas HC,Wong DV,Wanderley CW,Nunes LG,Leite LL,Miranda SP,Souza MH,Brito GA,Magalhães PJ,Teixeira MM,Cunha FQ,Ribeiro RA

更新日期：2014-05-01 00:00:00

abstract：:1. Microinjection of peptide YY (PYY, 7-46 pmol) into the dorsal vagal complex (DVC) stimulated gastric acid secretion in urethane-anaesthetized rats. Using a variety of neuropeptide Y (NPY) and PYY derivatives, we characterized the pharmacological profile of the receptor mediating the acid secretory response to PYY. ...

journal_title：British journal of pharmacology

authors： Yang H,Li WP,Reeve JR Jr,Rivier J,Taché Y

更新日期：1998-04-01 00:00:00

abstract：:The effects of several anticonvulsant drugs on sodium-dependent high affinity choline uptake (HACU) in mouse hippocampal synaptosomes was investigated. HACU was measured in vitro after in vivo administration of the drug to mice. HACU was inhibited by drugs which have in common the ability to facilitate gamma-aminobuty...

journal_title：British journal of pharmacology

authors： Miller JA,Richter JA

更新日期：1985-01-01 00:00:00

abstract：:1. A biliary fistula was prepared in twelve sheep.2. Each animal was given 2 ml. of (14)C-carbon tetrachloride (specific activity 15 mc/m-mole) and bile collected at 2, 4, 24 and 48 hr.3. Specific activity was measured by liquid scintillation counting before and after each specimen had been heated to 75 degrees C for ...

journal_title：British journal of pharmacology

authors： Khalidi A,Zaki SA

更新日期：1969-06-01 00:00:00

abstract：:1. Chronic treatment with a combined ETA/ETB endothelin receptor antagonist has been shown to reduce blood pressure in experimental rat models of hypertension in which endothelin-1 gene overexpression occurs in the walls of blood vessels, particularly small, resistance-sized arteries, but not in those genetic or exper...

journal_title：British journal of pharmacology

authors： Schiffrin EL,Turgeon A,Deng LY

更新日期：1997-07-01 00:00:00

abstract：:1. In order to define the electrophysiological mechanism(s) responsible for bradykinin (BK)-induced positive inotropic and chronotropic responses in isolated guinea-pig atria, effects of BK on the membrane currents were examined in isolated atrial cells using patch clamp techniques. 2. BK (0.1-1000 nM) increased the L...

journal_title：British journal of pharmacology

authors： Sakamoto N,Uemura H,Hara Y,Saito T,Masuda Y,Nakaya H

更新日期：1998-09-01 00:00:00

abstract：:Binding of the 5-HT(7) receptor antagonist radioligand [(3)H]-SB-269970 to human 5-HT(7(a)) receptors expressed in HEK293 cell membranes (h5-HT(7(a))/293) and to guinea-pig cerebral cortex membranes, was characterized and compared with [(3)H]-5-CT binding. [(3)H]-SB-269970 (1 nM) showed full association with h5-HT(7(a...

journal_title：British journal of pharmacology

authors： Thomas DR,Atkinson PJ,Ho M,Bromidge SM,Lovell PJ,Villani AJ,Hagan JJ,Middlemiss DN,Price GW

更新日期：2000-05-01 00:00:00

abstract：:1. This study examined beta-adrenoceptor signalling in cardiac tissues following infusion of isoprenaline (400 microg kg(-1) h(-1)) or vehicle to rats for 14 days. 2. Isoprenaline infusion caused marked hypertrophy of atria and ventricles and reduced the resting rate of spontaneously beating right atria and the basal ...

journal_title：British journal of pharmacology

authors： McMartin L,Summers RJ

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Screening of 12,000 compounds for binding affinity to the synaptic vesicle protein 2A (SV2A), identified a high-affinity pyrrolidone derivative, brivaracetam (ucb 34714). This study examined its pharmacological profile in various in vitro and in vivo models of seizures and epilepsy, to evaluate i...

journal_title：British journal of pharmacology

authors： Matagne A,Margineanu DG,Kenda B,Michel P,Klitgaard H

更新日期：2008-08-01 00:00:00

abstract：:1. Unique among the phospholipids, phosphatidylserine depresses brain energy metabolism when injected intravenously into mice in the form of sonicated liposomes. The possibility that this effect results from a metabolic transformation of phosphatidylserine is examined in this paper. 2. A strong enhancement of the phos...

journal_title：British journal of pharmacology

authors： Bigon E,Boarato E,Bruni A,Leon A,Toffano G

更新日期：1979-12-01 00:00:00

abstract：:The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect drug metabolism. More evidence now hints at the effects that drugs can have on the function and c...

journal_title：British journal of pharmacology

authors： Walsh J,Griffin BT,Clarke G,Hyland NP

更新日期：2018-12-01 00:00:00

abstract：:1 The question whether constriction of local vessels is essential for the anti-inflammatory action of glucocorticoids in carrageenin-induced granulomatous inflammation was studied. 2 The vasodilator prostaglandin E1 injection into the granuloma pouch fluid increased the exudation of plasma protein into the granuloma t...

journal_title：British journal of pharmacology

authors： Sugio K,Tsurufuji S

更新日期：1981-07-01 00:00:00

abstract：:1 Plasma noradrenaline concentrations were similar in rats following unilateral renal arterial constriction (two kidney Goldblatt model) and in sham-operated control rats. 2 The development of hypertension was not affected by pretreatment with intracisternal injections of 6-hydroxydopamine. 3 These data suggest that s...

journal_title：British journal of pharmacology

authors： Dargie HJ,Franklin SS,Reid JL

更新日期：1977-10-01 00:00:00

abstract：:1. Ca2+ buffering function of sarcoplasmic reticulum (SR) in the resting state of arteries from spontaneously hypertensive rats (SHR) was examined. Differences in the effects of cyclopiazonic acid (CPA) and thapsigargin, agents which inhibit the Ca(2+)-ATPase of SR, on tension and cellular Ca2+ level were assessed in ...

journal_title：British journal of pharmacology

authors： Nomura Y,Asano M,Ito K,Uyama Y,Imaizumi Y,Watanabe M

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prefrontal dopamine release by the combined activation of 5-HT1A and sigma-1 (σ1 ) receptors is enhanced by the GABAA receptor antagonist picrotoxin in mice. Here, we examined whether this neurochemical event was accompanied by behavioural changes. EXPERIMENTAL APPROACH:Male mice were treated wi...

journal_title：British journal of pharmacology

authors： Hasebe S,Ago Y,Watabe Y,Oka S,Hiramatsu N,Tanaka T,Umehara C,Hashimoto H,Takuma K,Matsuda T

更新日期：2017-02-01 00:00:00

abstract：:1. The current study investigated the effects of respiratory tract viral infection on the density of ETA and ETB receptors in murine tracheal smooth muscle and on the contractile response to endothelin-1 mediated by these receptors. 2. Quantitative autoradiographic studies using [125I]-endothelin-1 revealed that trach...

journal_title：British journal of pharmacology

authors： Henry PJ,Goldie RG

更新日期：1994-08-01 00:00:00

abstract：:1. The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water...

journal_title：British journal of pharmacology

authors： Vickers SP,Benwell KR,Porter RH,Bickerdike MJ,Kennett GA,Dourish CT

更新日期：2000-07-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) evoked potent contractile responses in phenoxybenzamine-treated ring segments of rat caudal artery, partially contracted with U46619. Responses were mimicked by 5-HT1-selective agonists with the potency order: RU24969 > 5-carboxamidotryptamine > 5-HT = CP-93,129 > sumatriptan. 8-Hydroxy-N,N-...

journal_title：British journal of pharmacology

authors： Craig DA,Martin GR

更新日期：1993-07-01 00:00:00

abstract：:The use of the procaine-blocked hemisected spinal cord preparation to identify the primary action of amino acids and their antagonists on amphibian mononeurones is described. 2 Apart from an anomalous effect of glycine, the responses of frog spinal motoneurones to amino acids were shown to be similar to those of mamma...

journal_title：British journal of pharmacology

authors： Evans RH,Watkins JC

更新日期：1975-12-01 00:00:00

abstract：:1. Membranes from rat cerebral cortex, myocardium and extraorbital lacrimal gland were used as sources of M1, M2 and M3 muscarinic acetylcholine receptors respectively and the affinities of seven antagonists for the three subtypes were examined under different experimental conditions. 2. The affinities for the membran...

journal_title：British journal of pharmacology

authors： Pedder EK,Eveleigh P,Poyner D,Hulme EC,Birdsall NJ

更新日期：1991-06-01 00:00:00

abstract：:1. The endothelial modulation of the relaxant responses to the nitric oxide (NO) donor sodium nitroprusside (SNP) and the KATP channel opener levcromakalim (LEM) and the interactions between these agents were analysed in isolated rat aorta. 2. LEM-induced relaxation was unchanged by endothelium removal or by the prese...

journal_title：British journal of pharmacology

authors： Pérez-Vizcaíno F,Cogolludo AL,Zaragozá-Arnáez F,Fajardo S,Ibarra M,López-López JG,Tamargo J

更新日期：1999-12-01 00:00:00

abstract：:British Journal of Pharmacology (BJP) is pleased to publish a new set of guidelines for reporting research involving animals, simultaneously with several other journals; the 'ARRIVE' guidelines (Animals in Research: Reporting In Vivo Experiments). This editorial summarizes the background to the guidelines, gives our v...

journal_title：British journal of pharmacology

authors： McGrath JC,Drummond GB,McLachlan EM,Kilkenny C,Wainwright CL

更新日期：2010-08-01 00:00:00

abstract：:1. Nine non-steroidal anti-inflammatory drugs were tested for antagonism of bradykinin-induced bronchoconstriction in guinea-pig lungs in vivo. Only one, benzydamine, was inactive.2. The descending order of potency of the active anti-inflammatory drugs was meclofenamate = Scha 306>Scha 87/2>indoxole>Mi85>indomethacin>...

journal_title：British journal of pharmacology

authors： Collier HO,James GW,Piper PJ

更新日期：1968-09-01 00:00:00

abstract：BACKGROUND:Macrophage elastase (MMP-12) is involved in the inflammatory process of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate in mice the effect of MMP-12 inhibition on the inflammatory process induced by cigarette smoke (CS) or by lipopolysaccharide (LPS) exposure of the air...

journal_title：British journal of pharmacology

authors： Le Quément C,Guénon I,Gillon JY,Valença S,Cayron-Elizondo V,Lagente V,Boichot E

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The beneficial effect of 5-HT6 receptor antagonism in cognition remains controversial. This study has been undertaken to reassess the cognition enhancing properties of acute vs subchronic treatment with the selective 5-HT6 receptor antagonist SB-271046 in unimpaired rats, as well as against scopo...

journal_title：British journal of pharmacology

authors： Marcos B,Chuang TT,Gil-Bea FJ,Ramirez MJ

更新日期：2008-10-01 00:00:00