Abstract：
:The antidiarrhoeal effects of the methanol extract of Zizyphus spina-christi stem bark were evaluated in laboratory rodents. Studies on castor oil induced diarrhoea, intraluminal fluid accumulation, and gastrointestinal transit time were carried out. Results obtained revealed that the extract caused a dose dependent protection of rats against castor oil induced diarrhoea, decreased the intraluminal fluid accumulation and gastrointestinal transit. The intraperitoneal and oral LD(50) values were found to be 346+/-5.6 and 1200+/-41.2 mg/kg in mice. Preliminary phytochemical screening revealed the presence of glycosides, resins, saponins, and tannins. It is suggested that the extract may contain biologically active components that may be useful against diarrhoea, thereby justifying its use in ethnomedical practice as an antidiarrhoeal agent.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Adzu B,Amos S,Amizan MB,Gamaniel Kdoi
10.1016/s0001-706x(03)00114-1subject
Has Abstractpub_date
2003-07-01 00:00:00pages
245-50issue
2eissn
0001-706Xissn
1873-6254pii
S0001706X03001141journal_volume
87pub_type
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