Abstract:
:Aging per se is associated with abnormalities of the vascular wall linked to both structural and functional changes that can take place at the level of the extracellular matrix, the vascular smooth muscle and the endothelium of blood vessels. Endothelial dysfunction is generally defined as a decrease in the capacity of the endothelium to dilate blood vessels in response to physical and chemical stimuli. It is one of the characteristic changes that occur with age, independently of other known cardiovascular risk factors. This may account in part for the increased incidence of cardiovascular events in elderly people that can be reversed by restoring endothelial function. A better understanding of the mechanisms involved and the aetiopathogenesis of this process will help in the search for new therapeutic agents.Age-dependent alteration of endothelium-dependent relaxation seems to be a widespread phenomenon both in conductance and resistance arteries from several species. In the course of aging, there is an alteration in the equilibrium between relaxing and contracting factors released by the endothelium. Hence, there is a progressive reduction in the participation of nitric oxide and endothelium-derived hyperpolarising factor associated with increased participation of oxygen-derived free radicals and cyclo-oxygenase-derived prostanoids. Also, the endothelin-1 and angiotensin II pathways may play a role in age-related endothelial dysfunction. The use of drugs acting at different levels of these signalling cascades, including antioxidant therapy, lipid-lowering drugs and estrogens, seems to be promising.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Matz RL,Andriantsitohaina Rdoi
10.2165/00002512-200320070-00005subject
Has Abstractpub_date
2003-01-01 00:00:00pages
527-50issue
7eissn
1170-229Xissn
1179-1969pii
2075journal_volume
20pub_type
杂志文章,评审相关文献
DRUGS & AGING文献大全abstract::Giant cell arteritis (GCA) is an inflammatory vasculopathy that involves large- and medium-sized arteries and can cause vision loss, stroke and aneurysms. GCA occurs in people aged >50 years and is more common in women. A higher incidence of the disease is observed in populations from Northern European countries. Poly...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11592500-000000000-00000
更新日期:2011-08-01 00:00:00
abstract::Unfortunately the sections were published incorrectly in the original article. ...
journal_title:Drugs & aging
pub_type: 已发布勘误
doi:10.1007/s40266-020-00807-5
更新日期:2020-11-01 00:00:00
abstract::Aging is associated with a myriad of hormonal changes. The mechanisms underlying these changes are variable. Aging is associated with anatomic changes of the endocrine glands, notably as a result of programmed cell death, autoimmune mediated destruction of the gland, or neoplastic transformation of glandular tissue. A...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199303020-00004
更新日期:1993-03-01 00:00:00
abstract::Although use of NSAIDs and aspirin (acetylsalicylic acid) is well known to be associated with gastrointestinal (GI) complications and potential mortality, these medications continue to be widely prescribed in the elderly. Age is a significant risk factor for NSAID-induced GI events; indeed, patients >75 years of age c...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200724020-00004
更新日期:2007-01-01 00:00:00
abstract::Pneumococcal polysaccharide conjugate vaccine (13-valent, adsorbed) (PCV13; Prevenar 13(®); Prevnar 13(®)) is approved in adults aged ≥50 years (focus of review) and in children aged 6 weeks to 5 years for protection against pneumococcal diseases caused by Streptococcus pneumoniae in numerous countries worldwide, incl...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-012-0017-0
更新日期:2012-10-01 00:00:00
abstract::CATT (Comparison of Age-related macular degeneration [AMD] Treatment Trials) examined the efficacy of ranibizumab and bevacizumab for the treatment of neovascular AMD. This prospective, randomized, but unblinded trial revealed a significant improvement in vision with both treatments in terms of visual acuity; importan...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11594720-000000000-00000
更新日期:2011-11-01 00:00:00
abstract::The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00706-4
更新日期:2019-12-01 00:00:00
abstract::New treatments and treatment protocols for diseases affecting the elderly are evolving as we strive to meet the needs of an aging society. To help you keep up to date with the latest advances worldwide on all aspects of drug therapy and patient management, this section of the journal brings you information selected fr...
journal_title:Drugs & aging
pub_type:
doi:10.2165/00002512-200623070-00008
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Statins have been shown to be beneficial in primary and secondary prevention settings; however, their role in the elderly remains a clinical conundrum, given that age-related factors could alter the risk-benefit ratio of statin treatment. This study aimed to critically evaluate the efficacy and safety of sta...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s40266-015-0290-9
更新日期:2015-08-01 00:00:00
abstract::Donepezil (E-2020) is a reversible, noncompetitive, piperidine-type cholinesterase inhibitor. It is selective for acetylcholinesterase rather than butyrylcholinesterase. Donepezil 5 and 10 mg/day significantly improved cognition and global clinical function compared with placebo in well designed short term trials (14 ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200016030-00005
更新日期:2000-03-01 00:00:00
abstract::The fluoroquinolones are antibiotics frequently used in infections that affect elderly individuals. The physiological aging process can profoundly affect the pharmacokinetics of drugs, necessitating adjustment of dosage regimens in the elderly. Changes in pharmacokinetics with age are mainly due to the progressive det...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199101040-00004
更新日期:1991-07-01 00:00:00
abstract::Behavioural disturbances, also termed neuropsychiatric symptoms, are a frequent clinical feature of dementia in Alzheimer's disease (AD). Many AD patients receive treatment with cholinesterase inhibitors (ChEIs). This review examines the evidence for behavioural effects of the four ChEIs that have been approved for th...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200623120-00003
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Medication for elderly patients is often complex and problematic. Several criteria for classifying inappropriate prescribing exist. In 2010, the Swedish National Board of Health and Welfare published the document "Indicators of appropriate drug therapy in the elderly" as a guideline for improving prescribing...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-014-0165-5
更新日期:2014-05-01 00:00:00
abstract::Psoriatic arthritis (PsA) can start in subjects aged over 60 years, defined as late-onset PsA. In late-onset PsA, the weight of family history and genetic background appears less significant when compared with younger onset PsA, whereas obesity and smoking have been suggested as potential risk factors. In patients wit...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00688-3
更新日期:2019-10-01 00:00:00
abstract::The alcohol withdrawal syndrome is common in elderly individuals who are alcohol dependent and who decrease or stop their alcohol intake. While there have been few clinical studies to directly support or refute the hypothesis that withdrawal symptom severity, delirium and seizures increase with advancing age, several ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199914060-00002
更新日期:1999-06-01 00:00:00
abstract::Melatonin prolonged release (PR) 2 mg is approved for the treatment of primary insomnia characterized by poor sleep quality in patients aged ≥55 years in the EU and elsewhere. Patients may receive treatment with melatonin PR for up to 13 weeks. Production of endogenous nocturnal melatonin, which helps regulate circadi...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-012-0018-z
更新日期:2012-11-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) has considerable morbidity and mortality in the older adult population. The role of antibiotics in the management of acute exacerbations of COPD (AECOPD) is currently evolving. Despite only mild benefits, most patients with AECOPD in ambulatory settings receive antibiotics ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-020-00786-7
更新日期:2020-09-01 00:00:00
abstract::Pharmacological treatment of depression in old age is associated with an increased risk of adverse pharmacokinetic and pharmacodynamic drug interactions. Elderly patients may have multiple disease states and, therefore, may require a variety of other drugs. In addition to polypharmacy, other factors such as age-relate...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219040-00004
更新日期:2002-01-01 00:00:00
abstract::Management of hypertension in the elderly should take into account, in particular, the possible negative impact of antihypertensive drugs on the patient's quality of life, the deterioration of which may result in a loss of independence and reduced treatment compliance. Quality of life is recognised as a multifactorial...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421060-00003
更新日期:2004-01-01 00:00:00
abstract::In general, the pharmacological treatment of non-psychotic major depressive disorder in old age is only partially successful, with only approximately 50% of older depressed adults improving with initial antidepressant monotherapy. Many factors may predict a more difficult-to-treat depression, including coexisting anxi...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200724100-00002
更新日期:2007-01-01 00:00:00
abstract::The atypical antipsychotics are a new class of agents with great promise for use in the elderly because of their reduced propensity to cause acute extrapyramidal adverse effects. Treatment of older patients with these agents, however, needs to take into consideration age-related changes in pharmacokinetics and the ris...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812020-00004
更新日期:1998-02-01 00:00:00
abstract::beta-Adrenoceptor antagonists (beta-blockers) reduce mortality and recurrent myocardial infarction (MI) in older patients after both Q-wave MI and non-Q-wave MI. The effects of beta-blockers are to: (i) reduce complex ventricular arrhythmias, including ventricular tachycardia; (ii) increase the ventricular fibrillatio...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711060-00002
更新日期:1997-12-01 00:00:00
abstract::Healthcare systems worldwide are facing an unprecedented demographic change as globally, the number of older people will triple to 2 billion by the year 2050. The resulting pressures on acute services have been instrumental in the development of intermediate care (IC) as a new healthcare model, which has its origins i...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-013-0133-5
更新日期:2014-01-01 00:00:00
abstract::Faecal incontinence occurs in up to 10% of community dwelling persons > or = 65 years of age and approximately 50% of nursing home residents. It is a vastly under-reported problem that has a devastating effect on those who experience it as well as their spouses and caregivers. There are three broad categories of faeca...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522020-00004
更新日期:2005-01-01 00:00:00
abstract::The elderly patient may show normal physiological changes of the cardiovascular and respiratory systems that accompany aging, as well as features of intrinsic cardiac disease. The latter include: a past history of myocardial infarction or ischaemic heart disease; history of congestive cardiac failure; angina; arterial...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219060-00003
更新日期:2002-01-01 00:00:00
abstract::The elderly population has much to gain from the advances of molecular medicine, although at present genetic pharmacology remains mostly at the conceptual level. Cancer, in particular, is an increasing health burden and the majority (over 70%) of gene therapy trials are aimed at tackling this problem. Available strate...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200017020-00004
更新日期:2000-08-01 00:00:00
abstract::Influenza infection is an acute respiratory disease with a high morbidity and significant mortality, particularly among the elderly and individuals with chronic diseases. The majority of countries now recommend annual influenza vaccination for all people aged 65 years or older, and for those with high risk conditions....
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199915030-00001
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Home care (HC) patients are characterized by a high level of complexity, which is reflected by the prevalence of multimorbidity and the correlated high drug consumption. This study assesses prevalence and factors associated with polypharmacy in a sample of HC patients in Europe. METHODS:We conducted a cross...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0521-y
更新日期:2018-02-01 00:00:00
abstract::The focus of this review is hormone replacement therapy (HRT) with continuous oral 17 beta-estradiol (herein referred to as estradiol) 2 mg/day plus sequential oral dydrogesterone 10 or 20 mg/day for 14 days of each 28-day cycle. According to data from nonblind trials, this regimen relieves climacteric symptoms, prese...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199711040-00006
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Increased life expectancy is associated with an increased prevalence of chronic diseases and drug consumption. Changes often occur in the medication regimen after hospitalization. The extent and nature of these changes and the adherence of elderly patients have not yet been fully investigated. OBJECTIVE:To ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200825100-00005
更新日期:2008-01-01 00:00:00