Granisetron versus granisetron/dexamethasone combination for the treatment of nausea, retching, and vomiting after major gynecologic surgery: a randomized, double-blind study.

abstract：BACKGROUND:Aspirin is a widely used NSAID that has been extensively studied in numerous conditions. Nonprescription analgesics, such as aspirin, are frequently used for a wide variety of common ailments, including conditions such as dental pain and tension-type headache. OBJECTIVE:We sought to compare the efficacy and...

journal_title：Clinical therapeutics

authors： Gatoulis SC,Voelker M,Fisher M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Biosimilars are defined as biologic products that are highly similar to reference products, notwithstanding minor differences in clinically inactive components, with no clinically meaningful differences between the biologic product and the reference product in terms of safety profile, purity, and potency. Du...

journal_title：Clinical therapeutics

authors： Ahmed I,Kaspar B,Sharma U

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:One approach to treating allergic rhinoconjunctivitis is the concomitant use of an intranasal spray such as fluticasone propionate to alleviate nasal symptoms and a topical or systemic agent to relieve ocular symptoms. It has not yet been determined whether a topical or systemic agent is more effective for t...

journal_title：Clinical therapeutics

authors： Lanier BQ,Abelson MB,Berger WE,Granet DB,D'Arienzo PA,Spangler DL,Kägi MK

更新日期：2002-07-01 00:00:00

abstract：:The objective of this study was to compare the lipid-altering efficacy and safety of simvastatin with that of gemfibrozil in hypercholesterolemic patients with non-insulin-dependent diabetes mellitus (NIDDM). The study was a 24-week, double-blind, randomized, multicenter trial conducted at clinics and hospitals in the...

journal_title：Clinical therapeutics

authors： Sweany AE,Shapiro DR,Tate AC,Goldberg RB,Stein EA

更新日期：1995-03-01 00:00:00

abstract：:This paper explores how one health care purchasing coalition in Minnesota, the Buyers Health Care Action Group (BHCAG), has taken an active role in restructuring its local health care market. BHCAG started with the belief that the consumer should be the motivating force in health care delivery. Unfortunately, providin...

journal_title：Clinical therapeutics

authors： Robinow A

更新日期：1997-11-01 00:00:00

abstract：:Chancroid, the third most prevalent venereal disease in Thailand, was treated with a single 2-gm dose of spectinomycin, or two tablets of co-trimoxazole (trimethoprim-sulfamethoxazole) twice daily for seven days. The differences in cure rates between the two groups were statistically significant. The chancroidal ulcer...

journal_title：Clinical therapeutics

authors： Traisupa A,Ariyarit C,Metheeprapha C,Buatiang A,Sungthong P

更新日期：1990-05-01 00:00:00

abstract：:This article reviews the drugs used in the treatment of childhood asthma (bronchodilators and anti-inflammatory agents) from the perspective of their safety and clinical tolerability. Adverse events observed in adults are likely to be seen to a greater degree in children and adolescents for many types of antiasthma dr...

journal_title：Clinical therapeutics

authors： Selcow JE

更新日期：1994-07-01 00:00:00

abstract：:A 1-year, open-label extension of a 12-week, double-blind clinical trial was conducted to evaluate the long-term safety and efficacy of once-daily therapy with triamcinolone acetonide nasal aerosol (110, 220, or 440 micrograms) in 93 patients with perennial allergic rhinitis. All three doses of triamcinolone acetonide...

journal_title：Clinical therapeutics

authors： Welch MJ,Bronsky E,Findlay S,Pearlman DS,Southern DL,Storms WW,Weakley S

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to test the ability of human insulin 70/30, insulin lispro mixture 75/25 (75% neutral protamine lispro [NPL], 25% insulin lispro), and insulin lispro mixture 50/50 (50% NPL, 50% insulin lispro) to control postprandial glucose (PPG) concentrations in patients with type 2 diabetes mell...

journal_title：Clinical therapeutics

authors： Schwartz S,Zagar AJ,Althouse SK,Pinaire JA,Holcombe JH

更新日期：2006-10-01 00:00:00

abstract：:Congestive heart failure (CHF) afflicts more than 4.6 million people in the United States and increases at a rate of 400,000 newly diagnosed patients per year. With more than 1.5 million hospital admissions per year attributed to CHF, it is the number one cause of hospitalization. Hospital length of stay (LOS) is one ...

journal_title：Clinical therapeutics

authors： Simons WR,Haim M,Rizzo J,Zannad F

更新日期：1996-07-01 00:00:00

abstract：:Fourteen patients with serious infections caused by Staphylococcus aureus and other gram-positive bacteria were prospectively treated with chromatographically purified vancomycin in an open-label, nonrandomized study, between December 1986 and June 1987. Five patients were excluded from the evaluation of efficacy. Amo...

journal_title：Clinical therapeutics

authors： Wang LS,Liu CY,Wang FD,Fung CP,Chiu ZH,Cheng DL

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and is characterized by acute, extensive formation of nonfollicular sterile pustules on an erythematous and edematous substrate. Hydroxychloroquine (HHCQ), an antimalarial drug widely used to t...

journal_title：Clinical therapeutics

authors： Paradisi A,Bugatti L,Sisto T,Filosa G,Amerio PL,Capizzi R

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Patients with hypertension may require combination therapy to attain the blood pressure targets recommended by US and European treatment guidelines. Combination therapy with a calcium channel blocker and an angiotensin II-receptor blocker would be expected to provide enhanced efficacy. OBJECTIVES:Two studie...

journal_title：Clinical therapeutics

authors： Philipp T,Smith TR,Glazer R,Wernsing M,Yen J,Jin J,Schneider H,Pospiech R

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:The goal of this study was to assess the effect of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on lipid profiles in patients with type 2 diabetes. METHODS:The MEDLINE, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched from inception through October 31, 2013. Randomized controll...

journal_title：Clinical therapeutics

authors： Sun F,Wu S,Wang J,Guo S,Chai S,Yang Z,Li L,Zhang Y,Ji L,Zhan S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring (TDM) is essential to maintain the efficacy of many immunosuppressant drugs while minimizing their toxicity. TDM has become more refined with the development of new monitoring techniques and more specific assays. OBJECTIVE:This article summarizes current data on TDM of the follow...

journal_title：Clinical therapeutics

authors： Kahan BD,Keown P,Levy GA,Johnston A

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:The utilization pattern of dronedarone was unknown, especially regarding prescribers' compliance with the product's prescribing information (PI) following its availability and the implementation of the Food and Drug Administration-approved risk evaluation and mitigation strategy for the drug in the United St...

journal_title：Clinical therapeutics

authors： Gao S,Juhaeri J,Schiappacasse HA,Koren AT,Dai WS

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:In Korea, the treatment of hypertension and dyslipidemia constitutes an important strategy for the prevention of cardiovascular disease (CVD). OBJECTIVE:This study sought to investigate the cost-effectiveness (from the Korean health care system perspective) of prescribing a proprietary formulation single-ta...

journal_title：Clinical therapeutics

authors： Liew D,Park HJ,Ko SK

更新日期：2009-10-01 00:00:00

abstract：:This study evaluated the efficacy, safety, and most suitable dose of omeprazole in short-term acute treatment (4 weeks) and maintenance treatment (6 months) of patients older than 60 years of age with endoscopically diagnosed gastric ulcer (GU) or duodenal ulcer (DU). This randomized, prospective study included 156 pa...

journal_title：Clinical therapeutics

authors： Pilotto A,Di Mario F,Battaglia G,Vigneri S,Leandro G,Franceschi M,De Boni M,Grasso A,Vianello F,Naccarato R

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The real-world clinical effectiveness of exogenous insulin is limited by nonadherence. Various insulin delivery systems have been developed to help improve adherence, with prefilled pens gaining popularity among adult Singaporeans with diabetes. However, adherence to insulin in people with diabetes in Singap...

journal_title：Clinical therapeutics

authors： Cheen HH,Lim SH,Huang MC,Bee YM,Wee HL

更新日期：2014-07-01 00:00:00

abstract：:Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity. It has been the subject of more than 8,000 published papers, which include clinical reports of its usefulness in approximately 100 diseases and symptoms. In the United States the only indications for use in the official labelin...

journal_title：Clinical therapeutics

authors： Finkel MJ

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:It is unclear whether vitamin D provides any benefit against the pro-inflammatory effects of homocysteine in elderly patients with type 2 diabetes mellitus (T2DM). METHODS:We compared lymphocyte counts for CD3, CD19, CD4, and CD8 subsets between elderly (age ≥65 years) T2DM patients (n = 5098) and nondiabetes ...

journal_title：Clinical therapeutics

authors： Ma C,Zhao Y,Liu Z

更新日期：2020-10-01 00:00:00

abstract：:Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid family with demonstrated efficacy in the treatment of rheumatoid arthritis and osteoarthritis; a distinguished safety profile; and good tolerability. This report describes a new extended-release formulation that maintains therapeutic pla...

journal_title：Clinical therapeutics

authors： Schumacher HR Jr

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:We applied Multi-Criteria Decision Analysis (MCDA) methods in a structured benefit-risk assessment of cladribine and newer approved disease-modifying drugs (DMDs) for patients with relapsing-remitting multiple sclerosis (RRMS). METHODS:Decision conferencing with clinical neurologists as decision makers was use...

journal_title：Clinical therapeutics

authors： Vermersch P,Martinelli V,Pfleger C,Rieckmann P,Alonso-Magdalena L,Galazka A,Dangond F,Phillips L

更新日期：2019-02-01 00:00:00

abstract：:The monomeric insulin analogue insulin lispro (Lys B28, Pro B29) is a rapid-acting insulin with a shorter duration of activity than human regular insulin. This compound has the advantage of reducing early postprandial hyperglycemia and the accompanying late hypoglycemia, thereby improving overall blood glucose control...

journal_title：Clinical therapeutics

authors： Somwar R,Sweeney G,Ramlal T,Klip A

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Mexican Americans, the fastest growing ethnic group in the United States, have a 2- to 3-fold higher prevalence of type 2 diabetes mellitus relative to the non-Hispanic white population. It is estimated that 10% of Mexican Americans >or=20 years of age have diabetes. OBJECTIVE:The goal of this study was to ...

journal_title：Clinical therapeutics

authors： Luis Bautista J,Bugos C,Dirnberger G,Atherton T

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Most patients with hypertension in the United States and Europe fail to achieve the recommended target blood pressure (BP) of <140/90 mm Hg. Combination therapy is required in approximately two thirds of all patients whose BP is >20/10 mm Hg above the goal. Combination therapy with agents having complementar...

journal_title：Clinical therapeutics

authors： Poldermans D,Glazes R,Kargiannis S,Wernsing M,Kaczor J,Chiang YT,Yen J,Gamboa R,Fomina I

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:Our aim was to develop and validate the extrapolative performance of a regression model using a limited sampling strategy for accurate estimation of the area under the plasma concentration versus time curve for saroglitazar. METHODS:Healthy subject pharmacokinetic data from a well-powered food-effect study (fa...

journal_title：Clinical therapeutics

authors： Joshi SN,Srinivas NR,Parmar DV

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to characterize comprehensive medication therapy management (MTM) involving a community pharmacy and local physicians by describing the drug-related issues encountered, identifying which medication types were associated with these issues, and listing the actions taken by physicians a...

journal_title：Clinical therapeutics

authors： Doucette WR,McDonough RP,Klepser D,McCarthy R

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Inhaled antibacterial agents are used to manage chronic pulmonary infections in cystic fibrosis (CF) and non-CF bronchiectasis. However, established nebulized preparations impose a substantial time burden on patients. A dry powder formulation of ciprofloxacin for inhalation (ciprofloxacin DPI) has been devel...

journal_title：Clinical therapeutics

authors： Stass H,Weimann B,Nagelschmitz J,Rolinck-Werninghaus C,Staab D

更新日期：2013-10-01 00:00:00

abstract：:The United States Pharmacopeia (USP) Practitioners' Reporting Network utilized nearly three decades of experience to design and develop a nationwide, anonymous, Internet-accessible service for hospitals to report and benchmark medication errors (also known as "preventable adverse drug events"). As nationwide experient...

journal_title：Clinical therapeutics

authors： Cousins DD

更新日期：1998-01-01 00:00:00