FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface.

abstract：:Nuclear respiratory-defective mutants of Saccharomyces cerevisiae have been screened for lesions in the mitochondrial alpha-ketoglutarate dehydrogenase complex. Strains assigned to complementation group G70 were ascertained to be deficient in enzyme activity due to mutations in the KGD1 gene coding for the alpha-ketog...

journal_title：Molecular and cellular biology

authors： Repetto B,Tzagoloff A

更新日期：1989-06-01 00:00:00

abstract：:Mutations in the Drosophila mus308 gene confer specific hypersensitivity to DNA-cross-linking agents as a consequence of defects in DNA repair. The mus308 gene is shown here to encode a 229-kDa protein in which the amino-terminal domain contains the seven conserved motifs characteristic of DNA and RNA helicases and th...

journal_title：Molecular and cellular biology

authors： Harris PV,Mazina OM,Leonhardt EA,Case RB,Boyd JB,Burtis KC

更新日期：1996-10-01 00:00:00

abstract：:ABFI (ARS-binding protein I) is a yeast protein that binds specific DNA sequences associated with several autonomously replicating sequences (ARSs). ABFI also binds sequences located in promoter regions of some yeast genes, including DED1, an essential gene of unknown function that is transcribed constitutively at a h...

journal_title：Molecular and cellular biology

authors： Buchman AR,Kornberg RD

更新日期：1990-03-01 00:00:00

abstract：:The tumor suppressor gene PTEN is a phosphoinositide phosphatase that is inactivated by deletion and/or mutation in diverse human tumors. Wild-type PTEN is expressed both in the cytoplasm and nucleus in normal cells, with a preferential nuclear localization in differentiated or resting cells. To elucidate the relation...

journal_title：Molecular and cellular biology

authors： Liu JL,Sheng X,Hortobagyi ZK,Mao Z,Gallick GE,Yung WK

更新日期：2005-07-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) constitutes the most inherited kidney disease. Mutations in the PKD1 and PKD2 genes, encoding the polycystin 1 and polycystin 2 Ca2+ ion channels, respectively, result in tubular epithelial cell-derived renal cysts. Recent clinical studies demonstrate oxidative stre...

journal_title：Molecular and cellular biology

authors： Ishimoto Y,Inagi R,Yoshihara D,Kugita M,Nagao S,Shimizu A,Takeda N,Wake M,Honda K,Zhou J,Nangaku M

更新日期：2017-11-28 00:00:00

abstract：:Regulation of the endogenous mouse metallothionein I and II (MT-I and MT-II) genes by heavy metals and glucocorticoids was studied in cultured mouse cells. Both mRNAs were measured simultaneously by solution hybridization with [3H]MT-I cDNA and [32P]MT-II cDNA, and the absolute amount of each mRNA was calculated by us...

journal_title：Molecular and cellular biology

authors： Yagle MK,Palmiter RD

更新日期：1985-02-01 00:00:00

abstract：:Substantial evidence supports a critical role for the activation of the Raf-1/MEK/mitogen-activated protein kinase pathway in oncogenic Ras-mediated transformation. For example, dominant negative mutants of Raf-1, MEK, and mitogen-activated protein kinase all inhibit Ras transformation. Furthermore, the observation th...

journal_title：Molecular and cellular biology

authors： Khosravi-Far R,White MA,Westwick JK,Solski PA,Chrzanowska-Wodnicka M,Van Aelst L,Wigler MH,Der CJ

更新日期：1996-07-01 00:00:00

abstract：:As shown by Southern blot analysis, the metallothionein-1 (MT-1) genes in rats comprise a multigene family. We present the sequence of the MT-1 structural gene and compare its features with other metallothionein genes. Three MT-1 pseudogenes which we sequenced apparently arose by reverse transcription of processed mRN...

journal_title：Molecular and cellular biology

authors： Andersen RD,Birren BW,Taplitz SJ,Herschman HR

更新日期：1986-01-01 00:00:00

abstract：:The first intron of the human collagen alpha 1(I) gene contains several positively and negatively acting elements. We have studied the transcription of collagen-human growth hormone fusion genes, containing deletions and rearrangements of collagen intronic sequences, by transient transfection of chick tendon fibroblas...

journal_title：Molecular and cellular biology

authors： Bornstein P,McKay J,Liska DJ,Apone S,Devarayalu S

更新日期：1988-11-01 00:00:00

abstract：:The TAR RNA binding Protein, TRBP, inhibits the activity of the interferon-induced protein kinase R (PKR), whereas the PKR activator, PACT, activates its function. TRBP and PACT also bind to each other through their double-stranded RNA binding domains (dsRBDs) and their Medipal domains, which may influence their activ...

journal_title：Molecular and cellular biology

authors： Daher A,Laraki G,Singh M,Melendez-Peña CE,Bannwarth S,Peters AH,Meurs EF,Braun RE,Patel RC,Gatignol A

更新日期：2009-01-01 00:00:00

abstract：:Activins and other members of the transforming growth factor beta family play a critical role in morphological changes of the epidermis that require epithelial cell movement. We investigated the molecular pathways in the transmission of activin signals that lead to actin reorganization and epithelial cell migration. W...

journal_title：Molecular and cellular biology

authors： Zhang L,Deng M,Parthasarathy R,Wang L,Mongan M,Molkentin JD,Zheng Y,Xia Y

更新日期：2005-01-01 00:00:00

abstract：:Gamma interferon (IFN-γ) is an inflammatory cytokine that has complex effects on myogenesis. Here, we show that the IFN-γ-induced inhibition of myogenesis is mediated by the major histocompatibility complex (MHC) class II transactivator, CIITA, which binds to myogenin and inhibits its activity. In IFN-γ-treated myobla...

journal_title：Molecular and cellular biology

authors： Londhe P,Davie JK

更新日期：2011-07-01 00:00:00

abstract：:Activation-induced deaminase (AID) is essential for class switch recombination and somatic hypermutation, and it has the ability to deaminate single-stranded DNA at cytidines. Mammalian class switch regions form R-loops upon transcription in the physiological orientation. The displaced DNA strand of an R-loop is force...

journal_title：Molecular and cellular biology

authors： Yu K,Roy D,Bayramyan M,Haworth IS,Lieber MR

更新日期：2005-03-01 00:00:00

abstract：:Though widely recognized in higher eukaryotes, the regulation of Saccharomyces cerevisiae genes transcribed by RNA polymerase II by proteins that bind within the coding sequence remains largely speculative. We have shown for the LPD1 gene, encoding lipoamide dehydrogenase, that the coding sequence between +13 and +469...

journal_title：Molecular and cellular biology

authors： Sinclair DA,Kornfeld GD,Dawes IW

更新日期：1994-01-01 00:00:00

abstract：:The accurate segregation of chromosomes requires the kinetochore, a complex protein machine that assembles onto centromeric DNA to mediate attachment of replicated sister chromatids to the mitotic spindle apparatus. This study reveals an important role for the yeast RSC ATP-dependent chromatin-remodeling complex at th...

journal_title：Molecular and cellular biology

authors： Hsu JM,Huang J,Meluh PB,Laurent BC

更新日期：2003-05-01 00:00:00

abstract：:Multiple members of the A, B, and C clusters of Hox genes are expressed in hematopoietic cells. Several of these Hox genes have been found to display distinctive expression patterns, with genes located at the 3' side of the clusters being expressed at their highest levels in the most primitive subpopulation of human C...

journal_title：Molecular and cellular biology

authors： Thorsteinsdottir U,Sauvageau G,Hough MR,Dragowska W,Lansdorp PM,Lawrence HJ,Largman C,Humphries RK

更新日期：1997-01-01 00:00:00

abstract：:The c-Jun NH2-terminal protein kinase (JNK) is a member of the mitogen-activated protein kinase (MAPK) group and is an essential component of a signaling cascade that is activated by exposure of cells to environmental stress. JNK activation is regulated by phosphorylation on both Thr and Tyr residues by a dual-specifi...

journal_title：Molecular and cellular biology

authors： Tournier C,Whitmarsh AJ,Cavanagh J,Barrett T,Davis RJ

更新日期：1999-02-01 00:00:00

abstract：:CD26 is a T-cell costimulatory molecule with dipeptidyl peptidase IV enzyme activity in its extracellular region. We have previously reported that the addition of recombinant soluble CD26 resulted in enhanced proliferation of human T lymphocytes induced by the recall antigen tetanus toxoid (TT) via upregulation of CD8...

journal_title：Molecular and cellular biology

authors： Ohnuma K,Yamochi T,Uchiyama M,Nishibashi K,Iwata S,Hosono O,Kawasaki H,Tanaka H,Dang NH,Morimoto C

更新日期：2005-09-01 00:00:00

abstract：:We have constructed an ALDH3a1 null mouse to investigate the role of this enzyme that comprises nearly one-half of the total water-soluble protein in the mouse corneal epithelium. ALDH3a1-deficient mice are viable and fertile, have a corneal epithelium with a water-soluble protein content approximately half that of wi...

journal_title：Molecular and cellular biology

authors： Nees DW,Wawrousek EF,Robison WG Jr,Piatigorsky J

更新日期：2002-02-01 00:00:00

abstract：:Brain disturbances, like injuries or aberrant protein deposits, evoke nucleotide release or leakage from cells, leading to microglial chemotaxis and ingestion. Recent studies have identified P2Y12 purinergic receptors as triggers for microglial chemotaxis and P2Y6 receptors as mediators for phagocytosis. However, pino...

journal_title：Molecular and cellular biology

authors： Li HQ,Chen C,Dou Y,Wu HJ,Liu YJ,Lou HF,Zhang JM,Li XM,Wang H,Duan S

更新日期：2013-11-01 00:00:00

abstract：:The proteins of the Polycomb group (PcG) are required for maintaining regulator genes, such as the homeotic selectors, stably and heritably repressed in appropriate developmental domains. It has been suggested that PcG proteins silence genes by creating higher-order chromatin structures at their chromosomal targets, t...

journal_title：Molecular and cellular biology

authors： Breiling A,Bonte E,Ferrari S,Becker PB,Paro R

更新日期：1999-12-01 00:00:00

abstract：:Exchange proteins activated by cAMP (cyclic AMP) 2 (Epac2) is a guanine nucleotide exchange factor for Rap1, a small G protein involved in many cellular functions, including cell adhesion, differentiation, and exocytosis. Epac2 interacts with Ras-GTP via a Ras association (RA) domain. Previous studies have suggested t...

journal_title：Molecular and cellular biology

authors： Liu C,Takahashi M,Li Y,Song S,Dillon TJ,Shinde U,Stork PJ

更新日期：2008-12-01 00:00:00

abstract：:Glucose release from hepatocytes is important for maintenance of blood glucose levels. Glucose-6-phosphate phosphatase, catalyzing the final metabolic step of gluconeogenesis, faces the endoplasmic reticulum (ER) lumen. Thus, glucose produced in the ER has to be either exported from the ER into the cytosol before rele...

journal_title：Molecular and cellular biology

authors： Fehr M,Takanaga H,Ehrhardt DW,Frommer WB

更新日期：2005-12-01 00:00:00

abstract：:The Saccharomyces cerevisiae Nrd1-Nab3 pathway directs the termination and processing of short RNA polymerase II transcripts. Despite the potential for Nrd1-Nab3 to affect the transcription of both coding and noncoding RNAs, little is known about how the Nrd1-Nab3 pathway interacts with other pathways in the cell. Her...

journal_title：Molecular and cellular biology

authors： Darby MM,Serebreni L,Pan X,Boeke JD,Corden JL

更新日期：2012-05-01 00:00:00

abstract：:The expression of CD154 (CD40 ligand) by activated T lymphocytes plays a central role in humoral and cellular immunity. The fundamental importance of this protein in mounting an immune response has made it an attractive target for immunomodulation. Several studies have demonstrated that CD154 expression is regulated a...

journal_title：Molecular and cellular biology

authors： Hamilton BJ,Genin A,Cron RQ,Rigby WF

更新日期：2003-01-01 00:00:00

abstract：:The abundance of crystallins (> 80% of the soluble protein) in the ocular lens provides advantageous markers for selective gene expression during cellular differentiation. Here we show by functional and protein-DNA binding experiments that the chicken alpha A-crystallin gene is regulated by at least five control eleme...

journal_title：Molecular and cellular biology

authors： Cvekl A,Sax CM,Bresnick EH,Piatigorsky J

更新日期：1994-11-01 00:00:00

abstract：:V(D)J recombination requires binding and synapsis of a complementary (12/23) pair of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins, aided by a high-mobility group protein, HMG1 or HMG2. Double-strand DNA cleavage within this synaptic, or paired, complex is thought to involve DNA distortion or mel...

journal_title：Molecular and cellular biology

authors： Ciubotaru M,Schatz DG

更新日期：2004-10-01 00:00:00

abstract：:Tristetraprolin (TTP) regulates the expression of AU-rich element-containing mRNAs through promoting the degradation and repressing the translation of target mRNA. While the mechanism for promoting target mRNA degradation has been extensively studied, the mechanism underlying translational repression is not well estab...

journal_title：Molecular and cellular biology

authors： Tao X,Gao G

更新日期：2015-11-01 00:00:00

abstract：:The recombinant shuttle vector pSV2gpt was introduced into V79 Chinese hamster cells, and stable transformants expressing the Escherichia coli gpt gene were selected. Two transformants carrying tandem duplications of the plasmid at a single site were identified and fused to simian COS-1 cells. Plasmid DNA recovered fr...

journal_title：Molecular and cellular biology

authors： Ashman CR,Davidson RL

更新日期：1984-11-01 00:00:00

abstract：:The FLP protein of the Saccharomyces cerevisiae plasmid 2 microns circle catalyzes site-specific recombination between two repeated segments present on the plasmid. In this paper we present results of experiments we performed to define more precisely the features of the FLP recognition target site, which we propose to...

journal_title：Molecular and cellular biology

authors： McLeod M,Craft S,Broach JR

更新日期：1986-10-01 00:00:00