Iron status and neural functioning.

Abstract:

:Iron deficiency in early life is associated with delayed development as assessed by a number of clinical trials using similar global scales of development; this poor development during infancy persists in most cases after iron therapy has corrected iron status. If iron deficiency occurs in preschool and older children, the consequences appear reversible with treatment. The biologic understanding of this relationship between development, brain iron status, and functioning is sparse though animal studies repeatedly demonstrate alterations in dopamine metabolism and in the myelination process. Dietary iron deficiency can rapidly deplete brain iron concentrations and repletion is able to normalize them. Residual alterations in striatal dopamine metabolism and myelin production persist if neonatal animals are used. Future studies with more specific measures of neurodevelopment in iron-deficient human infants, and animal models, will allow investigators to more clearly define causal roles of brain iron in neural development and functioning.

journal_name

Annu Rev Nutr

authors

Beard JL,Connor JR

doi

10.1146/annurev.nutr.23.020102.075739

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

41-58

eissn

0199-9885

issn

1545-4312

pii

020102.075739

journal_volume

23

pub_type

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