Validity of direct assessment of functional status as a tool for measuring Alzheimer's disease severity.

Abstract:

OBJECTIVE:to assess the validity of the Direct Assessment of Functional Status (DAFS) performance-based functional scale for the staging of dementia severity by comparing it with established clinical, functional and cognitive scales. PATIENTS AND METHODS:93 consecutive Alzheimer's disease patients underwent DAFS. Socio-demographic variables, cognitive status (Mini-Mental State Examination; MMSE), global disease severity (Clinical Dementia Rating; CDR), disease duration, physical performance (Physical Performance Test, PPT) and functional status (as reported by the primary caregiver) were also recorded and basic (B) and instrumental (I) activities of daily living (ADL) assessed. RESULTS:a significant correlation was found between DAFS and MMSE (Pearson's r = 0.60; P < 0.01), PPT (r = 0.54; P < 0.01) and CDR (Spearman correlation coefficient: -0.48; P < 0.01). A mild, significant correlation was found between DAFS score and daily function as reported by the primary caregiver (r = -0.30 for BADL and r = - 0.27 for IADL). On multiple regression analysis, only MMSE and PPT were independently associated with the DAFS score, explaining 56% of DAFS total variance. ADL scales did not independently contribute to DAFS variance. A multivariate regression model of the association of DAFS with CDR showed that the association was significant even after adjustment for MMSE and PET, suggesting that DAFS scores provide additional information on dementia severity. CONCLUSION:DAFS is a valid tool for the assessment of dementia severity, capturing cognitive and physical aspects of disability.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Zanetti O,Frisoni GB,Rozzini L,Bianchetti A,Trabucchi M

doi

10.1093/ageing/27.5.615

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

615-22

issue

5

eissn

0002-0729

issn

1468-2834

journal_volume

27

pub_type

杂志文章
  • Improving the recording of the clinical assessment of stroke patients using a clerking pro forma.

    abstract::In this study we examine whether the introduction of a clerking pro forma improves the completeness of the recording of the management of stroke patients and we review methodological issues important in this type of audit. We prospectively identified 244 consecutive stroke patients before and after the introduction of...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/24.1.43

    authors: Davenport RJ,Dennis MS,Warlow CP

    更新日期:1995-01-01 00:00:00

  • Tuberculosis in older people--is it on the increase? Trends in notifications in Leeds from 1976 to 1996.

    abstract:OBJECTIVES:the absolute number of notifications for tuberculosis in older people appears to have increased in Scotland. To determine if these trends are present elsewhere in the UK, we have reviewed notifications in Leeds with particular reference to non-pulmonary disease, Asian subcontinent groups and older people. M...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/29.4.319

    authors: Phelan F,Teale C

    更新日期:2000-07-01 00:00:00

  • Does vitamin D stop inpatients falling? A randomised controlled trial.

    abstract:BACKGROUND:Vitamin D deficiency is common in older people and may increase risk of falls and fracture. Hospital inpatients are at particular risk of falling. Previous studies suggest that vitamin D improves neuromuscular function and reduces falls. OBJECTIVE:To determine whether routine supplementation with vitamin D ...

    journal_title:Age and ageing

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ageing/afm087

    authors: Burleigh E,McColl J,Potter J

    更新日期:2007-09-01 00:00:00

  • Urodynamic studies in the management of urinary incontinence in the elderly.

    abstract::An outline is given of simple urodynamic investigations applicable to elderly subjects. The type of patient presenting primarily to geriatric departments with urinary incontinence, whose management is aided by such studies, is described under various clinical groupings. The requirement for urodynamic studies and the b...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/8.1.41

    authors: Eastwood HD

    更新日期:1979-02-01 00:00:00

  • Lower urinary tract dysfunction in Parkinson's disease: changes relate to age and not disease.

    abstract::Lower urinary tract symptoms are frequency report in Parkinson's disease. Whether these are causally related to Parkinson's disease rather than the known effects of age on the urinary tract is unknown. In this study we compared urodynamic data from 1864 women and 357 men with no neurological disease with data from 34 ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/24.6.499

    authors: Gray R,Stern G,Malone-Lee J

    更新日期:1995-11-01 00:00:00

  • Prevalence of biliary lithiasis in the elderly people of a small town in Sicily.

    abstract::The aim of the present study was to determine the prevalence of biliary lithiasis (BL) and its major associated factors in the elderly people of a small town in Sicily. All inhabitants over the age of 65 were interviewed and underwent a general physical examination, blood tests and ultrasonography of the gallbladder a...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/21.5.338

    authors: Montalto G,Soresi M,Carroccio A,Averna MR,Muratore R,Li Castri C,Barbagallo CM,Cavera G,Sapienza M,Notarbartolo A

    更新日期:1992-09-01 00:00:00

  • Increasing delirium skills at the front door: results from a repeated survey on delirium knowledge and attitudes.

    abstract:BACKGROUND:delirium is under-recognised in comparison to other common and serious acute disorders. A 2006 survey of UK junior doctors (not undertaking specialist training) identified poor knowledge of the diagnostic criteria and treatment of delirium. We hypothesised that increased prominence accorded to delirium in th...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw066

    authors: Jenkin RP,Al-Attar A,Richardson S,Myint PK,MacLullich AM,Davis DH

    更新日期:2016-07-01 00:00:00

  • The impact of first- and second-eye cataract surgery on injurious falls that require hospitalisation: a whole-population study.

    abstract:BACKGROUND:cataract is a leading cause of reversible vision impairment and may increase falls in older adults. OBJECTIVE:to assess the risk of an injury due to a fall among adults aged 60+, 2 years before first-eye cataract surgery, between first-eye surgery and second-eye surgery and 2 years after second-eye surgery....

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/aft177

    authors: Meuleners LB,Fraser ML,Ng J,Morlet N

    更新日期:2014-05-01 00:00:00

  • Defining 'recovery' for delirium research: a systematic review.

    abstract:BACKGROUND:Delirium is a common neuropsychiatric disorder. The natural course is of an acute, fluctuating and often transient condition; however, accumulating evidence suggests that delirium can be associated with incomplete recovery. Despite a growing body of research, a lack of clarity exists regarding definition and...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afu152

    authors: Adamis D,Devaney A,Shanahan E,McCarthy G,Meagher D

    更新日期:2015-03-01 00:00:00

  • Bridging the gap: the effectiveness of teaming a stroke coordinator with patient's personal physician on the outcome of stroke.

    abstract:OBJECTIVES:to test the hypothesis as to whether persons newly discharged into the community following an acute stroke and assigned a stroke case manager would experience, compared to usual post-hospital care, better health-related quality of life (HRQL), fewer emergency room visits and less non-elective hospitalisation...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/ageing/afm133

    authors: Mayo NE,Nadeau L,Ahmed S,White C,Grad R,Huang A,Yaffe MJ,Wood-Dauphinee S

    更新日期:2008-01-01 00:00:00

  • New horizons in deprescribing for older people.

    abstract::Deprescribing has gained interest recently, driven by an ageing population seeing an increasing number living with multiple long-term conditions. This, coupled with disease-specific guidelines derived from clinical trials in younger people, has led to an increase in exposure to polypharmacy and the associated therapeu...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afz109

    authors: Woodford HJ,Fisher J

    更新日期:2019-11-01 00:00:00

  • Folate status and its relation to vitamin C in healthy elderly men and women.

    abstract::Plasma and red-cell folate levels and dietary folate intake were monitored for about six months, including two months during which supplementary vitamin C was given, in 21 healthy elderly men and women living at home in the north of England. Although biochemical values were consistently low in some subjects, no clinic...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/9.4.241

    authors: Bates CJ,Fleming M,Paul AA,Black AE,Mandal AR

    更新日期:1980-11-01 00:00:00

  • Prognostic factors for continued or rebleeding and death from gastrointestinal haemorrhage in the elderly.

    abstract::We analysed 103 episodes of upper gastrointestinal bleeding in 88 elderly patients (age 76 +/- 7.7 years) to determine which of a group of 52 clinical and laboratory variables, measured on admission, best predicted continued or rebleeding, and death in these patients. Variables which related directly to the size of th...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/16.4.208

    authors: Booker JA,Johnston M,Booker CI,Tydd T,Mitchell R

    更新日期:1987-07-01 00:00:00

  • Risk of imbalance in elderly people with impaired hearing or vision.

    abstract::We evaluated the effect of impaired hearing and vision on balance in a sample of 977 elderly people residing in the community. Of the sample, 21% reported balance problems, 27% vision problems, and 30% hearing problems. The increased relative risk for balance problems was 1.7 for each 10-year age increment. Women were...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/18.1.31

    authors: Gerson LW,Jarjoura D,McCord G

    更新日期:1989-01-01 00:00:00

  • Slicing the health service cake: the Islington study.

    abstract:BACKGROUND:Little is known about the factors that are associated with receipt of care in older people. This study aims to describe the pattern and predictors of service usage, by a representative sample of people aged 65 and over. METHOD:We assessed psychiatric and physical morbidity, formal and informal care and pres...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/31.6.445

    authors: Nelson T,Livingston G,Knapp M,Manela M,Kitchen G,Katona C

    更新日期:2002-11-01 00:00:00

  • Prevention of malnutrition in older people during and after hospitalisation: results from a randomised controlled clinical trial.

    abstract:OBJECTIVE:to prevent the occurrence of weight loss during hospitalisation and following discharge by daily oral supplementation. DESIGN:in a prospective, randomised, controlled study of 80 patients aged 75 or more, and at risk of undernutrition based on their initial Mini Nutritional Assessment score, patients were ra...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/32.3.321

    authors: Gazzotti C,Arnaud-Battandier F,Parello M,Farine S,Seidel L,Albert A,Petermans J

    更新日期:2003-05-01 00:00:00

  • Poor oral hygiene, oral microorganisms and aspiration pneumonia risk in older people in residential aged care: a systematic review.

    abstract:BACKGROUND:aspiration pneumonia increases hospitalisation and mortality of older people in residential aged care. OBJECTIVES:determine potentially pathogenic microorganisms in oral specimens of older people with aspiration pneumonia and the effect of professional oral care in reducing aspiration pneumonia risk. DATA ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa102

    authors: Khadka S,Khan S,King A,Goldberg LR,Crocombe L,Bettiol S

    更新日期:2021-01-08 00:00:00

  • Faecal incontinence in residential homes for the elderly: prevalence, aetiology and management.

    abstract::Faecal incontinence occurring at least once weekly was found in 10.3% of residents in 30 residential homes for the elderly. Fifty-two randomly-selected incontinent residents were prescribed treatment and the outcome was compared with 30 incontinent residents acting as controls. The vast majority of all incontinent res...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章

    doi:10.1093/ageing/15.1.41

    authors: Tobin GW,Brocklehurst JC

    更新日期:1986-01-01 00:00:00

  • The natural history of delirium in older hospitalized patients: a syndrome of heterogeneity.

    abstract:OBJECTIVES:To determine the presentation, course and duration of delirium in hospitalized older people. DESIGN:Observational cohort study. SETTING:Inpatient surgical and medical wards at a university hospital. PARTICIPANTS:432 people over the age of 65. MEASUREMENTS:All participants were screened daily for confusio...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/26.3.169

    authors: Rudberg MA,Pompei P,Foreman MD,Ross RE,Cassel CK

    更新日期:1997-05-01 00:00:00

  • An unusual cause of bruising in an 80-year-old woman.

    abstract:PRESENTATION:a previously fit 80-year-old woman presented with a 2-week history of spontaneous and extensive bruising affecting all four limbs. The severity was such that she required a transfusion of 8 units of blood. RESULTS OF INVESTIGATIONS:a markedly prolonged activated partial thromboplastin time which was only ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/29.3.261

    authors: Kelly J,Gattens M,Geraghty R

    更新日期:2000-05-01 00:00:00

  • Responsiveness of the Duke Social Support sub-scales in older women.

    abstract:OBJECTIVE:an abbreviated form of the Duke Social Support Index (DSSI) as used in a large longitudinal study of older Australian women was examined with respect to factors that might be expected to affect social support for older women over time. METHODS:in this large cohort study two sub-scales of the DSSI, one descri...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afn205

    authors: Pachana NA,Smith N,Watson M,McLaughlin D,Dobson A

    更新日期:2008-11-01 00:00:00

  • Visual acuity and contrast sensitivity in relation to falls in an elderly population.

    abstract::Visual acuity and contrast sensitivity were measured in 95 residents of a hostel for the aged (mean age = 83 years) using a dual-contrast letter chart and the Melbourne Edge Test (MET). Vision (as measured by visual acuity, the MET, low-contrast visual acuity, and difference between high- and low-contrast acuity) decr...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/20.3.175

    authors: Lord SR,Clark RD,Webster IW

    更新日期:1991-05-01 00:00:00

  • Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials.

    abstract:OBJECTIVE:to review systematically the range of case definitions and methods used to measure falls in randomised controlled trials. DESIGN/METHODS:a Cochrane review of fall prevention interventions was used to identify fall definitions in published trials. Secondary searches of various databases were used to identify ...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afi218

    authors: Hauer K,Lamb SE,Jorstad EC,Todd C,Becker C,PROFANE-Group.

    更新日期:2006-01-01 00:00:00

  • Platypnoea-orthodeoxia in an elderly man with patent foramen ovale and dilated ascending aorta.

    abstract::We report the case of an 85-year-old male with platypnoea-orthodeoxia associated with patent foramen ovale (PFO) and ectatic ascending aorta, in the absence of any significant pulmonary pathology. ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afr131

    authors: Nazir T,Polydorou D,Irwin RB,Cooper A,Woolfson P,Thomson A

    更新日期:2012-01-01 00:00:00

  • Evaluation of a simulation training programme for geriatric medicine.

    abstract:BACKGROUND:geriatrics encompasses diverse medical, social and ethical challenges requiring a multidimensional, interdisciplinary approach. Recent reports have highlighted failings in the care of older people. It is therefore vital that trainees in geriatrics are afforded opportunities to develop skills in managing this...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afv049

    authors: Braude P,Reedy G,Dasgupta D,Dimmock V,Jaye P,Birns J

    更新日期:2015-07-01 00:00:00

  • Patterns of emergency department attendance among older people in the last three months of life and factors associated with frequent attendance: a mortality follow-back survey.

    abstract:BACKGROUND:frequent emergency department (ED) attendance at the end of life disrupts care continuity and contradicts most patients' preference for home-based care. OBJECTIVE:to examine factors associated with frequent (≥3) end of life ED attendances among older people to identify opportunities to improve care. METHOD...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afz043

    authors: Bone AE,Evans CJ,Henson LA,Gao W,Higginson IJ,BUILDCARE study.

    更新日期:2019-09-01 00:00:00

  • Mortality of older patients with dementia after surgery for chronic subdural hematoma: a nationwide study.

    abstract:BACKGROUND:dementia is associated with an excess risk of death but mortality after chronic subdural hematoma (CSDH) evacuation in older people with dementia is unknown. We assessed the association between dementia and 1-year case-fatality in older persons undergoing CSDH evacuation. METHODS:we conducted a nationwide F...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa193

    authors: Tommiska P,Korja M,Siironen J,Kaprio J,Raj R

    更新日期:2020-10-06 00:00:00

  • Evidence for the validity of the Short-form 36 Questionnaire (SF-36) in an elderly population.

    abstract::The objective of this study was to determine whether the Short-form 36 Health Status Questionnaire (SF-36) is suitable for use in an elderly population. The SF-36 was administered by interview to a random sample of 827 adults from West Glamorgan. Among the 216 adults aged 65 and over the data were 98.8% complete. Evid...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/23.3.182

    authors: Lyons RA,Perry HM,Littlepage BN

    更新日期:1994-05-01 00:00:00

  • Factors associated with the wish to die in elderly people.

    abstract::This study aimed to determine the prevalence of the wish to die in elderly people and investigate the factors associated with it, in particular, whether factors other than depression contribute to the wish to die. Data were obtained from an Australian epidemiological survey of people aged 70 or more. Survey participan...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/24.5.389

    authors: Jorm AF,Henderson AS,Scott R,Korten AE,Christensen H,Mackinnon AJ

    更新日期:1995-09-01 00:00:00

  • Greater progression of athletic performance in older Masters athletes.

    abstract:BACKGROUND:The number of new world records has decreased substantially in most athletic events in recent years. There has been enormous growth in participation at Masters events, and older athletes have been competing at the highest levels with much younger athletes. However, the progression of athletic performance ove...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afv023

    authors: Akkari A,Machin D,Tanaka H

    更新日期:2015-07-01 00:00:00