1,25-Dihydroxyvitamin D3 inhibits thyroid hormone-induced osteocalcin expression in mouse osteoblast-like cells via a thyroid hormone response element.

abstract：:Estrogen plays an important role in many physiological events including carcinogenesis and the development of human breast cancer. However, the molecular mechanisms of estrogen signaling in cancers have not been clarified hitherto and accurate therapeutic prediction of breast cancer is earnestly desired. We first carr...

journal_title：Journal of molecular endocrinology

authors： Inoue A,Yoshida N,Omoto Y,Oguchi S,Yamori T,Kiyama R,Hayashi S

更新日期：2002-10-01 00:00:00

abstract：:We have generated hybridomas which secrete monoclonal antibodies to the AT1 subtype of the angiotensin II receptor (AT1 receptor). These were obtained after immunization of Balb C/c mice with synthetic peptides representing sequences from either the extracellular domain (residues 8-17) or the intracellular domain (res...

journal_title：Journal of molecular endocrinology

authors： Barker S,Marchant W,Ho MM,Puddefoot JR,Hinson JP,Clark AJ,Vinson GP

更新日期：1993-10-01 00:00:00

abstract：:The hypothalamic arcuate nucleus (ARC) represents a major component of the neuroendocrine reproductive axis and plays an important role in controlling the onset of puberty as well as age-associated reproductive senescence. Although significant gene expression changes have been observed in the ARC during sexual maturat...

journal_title：Journal of molecular endocrinology

authors： Eghlidi DH,Garyfallou VT,Kohama SG,Urbanski HF

更新日期：2017-08-01 00:00:00

abstract：:The human progesterone receptor (PR) is a ligand-dependent transcription factor and two isoforms, (PRA and PRB), can be distinguished. PROGINS, a PR polymorphic variant, affects PRA and PRB and acts as a risk-modulating factor in several gynaecological disorders. Little is known about the functional consequences of th...

journal_title：Journal of molecular endocrinology

authors： Romano A,Delvoux B,Fischer DC,Groothuis P

更新日期：2007-02-01 00:00:00

abstract：:Evidence indicates that central regulation of food intake is well conserved along the vertebrate lineage, at least between teleost fish and mammals. However, several differences arise in the comparison between both groups. In this review, we describe similarities and differences between teleost fish and mammals on an ...

journal_title：Journal of molecular endocrinology

authors： Soengas JL,Cerdá-Reverter JM,Delgado MJ

更新日期：2018-05-01 00:00:00

abstract：:We have cloned a full length cDNA coding for the activin type IIB receptor (GactRIIB) from the goldfish ovary. GactRIIB shares 73 and 70% amino acid identity in the extracellular domain, and 78 and 80% identity in the intracellular domain with the type IIB receptors of the mouse and Xenopus respectively. The intracell...

journal_title：Journal of molecular endocrinology

authors： Ge W,Tanaka M,Yoshikuni M,Eto Y,Nagahama Y

更新日期：1997-08-01 00:00:00

abstract：:Oxytocin (OXT) is a peptide hormone that plays a central role in the regulation of parturition and lactation. OXT signaling is mediated by OXT receptor (OXTR), which shows species- and tissue-specific expressions and gene regulation. In the present study, we examined the synthesis of OXT and OXTR in human placenta tis...

journal_title：Journal of molecular endocrinology

authors： Kim SC,Lee JE,Kang SS,Yang HS,Kim SS,An BS

更新日期：2017-10-01 00:00:00

abstract：:CRH and its structurally related peptide urocortin (Ucn) are released under stress. Ucn is a potent agonist for CRH-receptor 2 (CRH-R2), which is strongly expressed in rodent heart. Stress induces Ucn mRNA expression in the heart, where it may be cardioprotective. However, increasing evidence indicates that Ucn may al...

journal_title：Journal of molecular endocrinology

authors： Huang M,Kempuraj D,Papadopoulou N,Kourelis T,Donelan J,Manola A,Theoharides TC

更新日期：2009-05-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), transforming growth factor alpha (TGFalpha) and epidermal growth factor (EGF) induced cathepsin D gene expression and reporter gene activity in MCF-7 human breast cancer cells transiently transfected with a construct (pCD1) containing a -2576 to -124 cathepsin D gene promoter inse...

journal_title：Journal of molecular endocrinology

authors： Wang F,Duan R,Chirgwin J,Safe SH

更新日期：2000-04-01 00:00:00

abstract：:Parathyroid hormone (PTH), a powerful bone-resorbing agent, is capable of stimulating interstitial collagenase (MMP-13) mRNA production in osteoblastic cells. In this study, a PEA3 consensus binding sequence (-80; AGGAAGT) in addition to a 'TRE-like' sequence (-89; CGACTCA) in the 5' upstream regulatory region of the ...

journal_title：Journal of molecular endocrinology

authors： Quinn CO,Rajakumar RA,Agapova OA

更新日期：2000-08-01 00:00:00

abstract：:Decreased suppressors of cytokine signaling (SOCS) activity in human gestational tissues may play a part in the onset/progression of term labor. Since SOCS proteins negatively regulate cytokine-mediated inflammatory processes, we hypothesized that SOCS proteins are elevated in gestational tissues from spontaneous pret...

journal_title：Journal of molecular endocrinology

authors： Blumenstein M,Keelan JA,Bowen-Shauver JM,Mitchell MD

更新日期：2005-08-01 00:00:00

abstract：:Secretion of parathyroid hormone-related protein (PTHrP) by sheep fetal parathyroid glands is reported to be an important factor in the maintenance of a placental calcium pump. The aim of the present study was to determine whether the developing rat parathyroid glands express PTHrP or parathyroid hormone (PTH), or bot...

journal_title：Journal of molecular endocrinology

authors： Tucci J,Russell A,Senior PV,Fernley R,Ferraro T,Beck F

更新日期：1996-10-01 00:00:00

abstract：:The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new markers and targets for prostate cancer treatment. Glycine N-meth...

journal_title：Journal of molecular endocrinology

authors： Ottaviani S,Brooke GN,O'Hanlon-Brown C,Waxman J,Ali S,Buluwela L

更新日期：2013-11-07 00:00:00

abstract：:The nociceptin receptor (NOP) and its endogenous ligand, nociceptin/orphanin FQ (OFQ), are involved in a wide range of biological functions, such as pain, anxiety, learning, and memory. The zebrafish has been proposed as a candidate to study the in vivo effects of several drugs of abuse and to discover new pharmacolog...

journal_title：Journal of molecular endocrinology

authors： Rivas-Boyero AA,Herrero-Turrión MJ,Gonzalez-Nunez V,Sánchez-Simón FM,Barreto-Valer K,Rodríguez RE

更新日期：2011-03-03 00:00:00

abstract：:A prolactin cDNA was cloned from a cDNA expression library constructed from total RNA of bullfrog (Rana catesbeiana) adenohypophyses by immunoscreening with antiserum against bullfrog prolactin. The cDNA clone thus obtained contained a 249 bp insert. Using this clone as a probe, plaque hybridizations were performed an...

journal_title：Journal of molecular endocrinology

authors： Takahashi N,Yoshihama K,Kikuyama S,Yamamoto K,Wakabayashi K,Kato Y

更新日期：1990-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is synthesized from a precursor, which includes the PACAP-related peptide (PRP; formerly known as GHRH-like peptide). PRP can act as a hypophysiotropic factor in teleosts by stimulating GH secretion. However, no information points to this peptide as a regulato...

journal_title：Journal of molecular endocrinology

authors： Levy G,Degani G

更新日期：2011-03-03 00:00:00

abstract：:To assess the functional significance of putative proteins encoded by alternately spliced mRNA of the sheep testicular FSH receptor, a short form cDNA comprising of the first four exons (117 residues mature protein) was engineered for expression in Escherichia coli. The expressed protein of molecular mass 15 kDa was p...

journal_title：Journal of molecular endocrinology

authors： Khan H,Jiang LG,Jayashree GN,Yarney TA,Sairam MR

更新日期：1997-10-01 00:00:00

abstract：:Transportation of vitamin C [also called ascorbic acid (AA)], an important water-soluble antioxidant and cofactor in testis, requires glucose transporter family (GLUTs) and sodium/vitamin C cotransporter family (SVCT1 and SVCT2). There is so far scant information vis-à-vis the functional roles of SVCTs in testis, alth...

journal_title：Journal of molecular endocrinology

authors： Gao G,Zhao Y,Wang K,Wang F

更新日期：2020-12-01 00:00:00

abstract：:Chronic inflammation is involved in the genitourinary syndrome of menopause (GSM) and beneficial effects of androgens in the vagina have been described. We investigated the potential involvement of human vagina smooth muscle cells (hvSMCs) in the inflammatory response and the immunomodulatory effect of androgen recept...

journal_title：Journal of molecular endocrinology

authors： Maseroli E,Cellai I,Filippi S,Comeglio P,Cipriani S,Rastrelli G,Rosi M,Sorbi F,Fambrini M,Petraglia F,Amoriello R,Ballerini C,Lombardelli L,Piccinni MP,Sarchielli E,Guarnieri G,Morelli A,Maggi M,Vignozzi L

更新日期：2020-10-01 00:00:00

abstract：:Two marsupial casein genes have been isolated from a tammar wallaby (Macropus eugenii) mammary gland cDNA library. Comparisons of the tammar alpha- and beta-casein genes with their eutherian homologous reveal extensive divergence at the levels of nucleotide and amino acid sequences. Regions of similarity between the t...

journal_title：Journal of molecular endocrinology

authors： Collet C,Joseph R,Nicholas K

更新日期：1992-02-01 00:00:00

abstract：:Murine double minute clone 2 (MDM2) is a multifunctional protein, which modulates nuclear receptor-mediated transactivation. In this study, we show that MDM2 significantly enhanced estrogen receptor α (ERα) and ERα/specificity protein-mediated transactivation in MCF-7 and ZR-75 breast cancer cells. This was demonstrat...

journal_title：Journal of molecular endocrinology

authors： Kim K,Burghardt R,Barhoumi R,Lee SO,Liu X,Safe S

更新日期：2011-02-15 00:00:00

abstract：:Breast cancer is a heterogeneous disease, and the complexity of breast carcinogenesis is associated with epigenetic modification. There are several major classes of epigenetic enzymes that regulate chromatin activity. This review will focus on the nine mammalian protein arginine methyltransferases (PRMTs) and the dysr...

journal_title：Journal of molecular endocrinology

authors： Wang SM,Dowhan DH,Muscat GEO

更新日期：2019-04-01 00:00:00

abstract：:Enhanced inflammation and reduced apoptosis sustain the growth of endometriotic lesions. Alterations in the expression of estrogen receptor-alpha (ERα) and estrogen receptor-beta (ERβ) accompany the conversion of resident endometrial cells within the normal uterine environment to ectopic lesions located in extrauterin...

journal_title：Journal of molecular endocrinology

authors： Simmen RC,Kelley AS

更新日期：2016-08-01 00:00:00

abstract：:Successful human embryo implantation requires a proper differentiation of endometrial stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs express specific molecules, such as prolactin, insulin-like growth factor-binding protein-1 (IGFBP-1) and connexin-43. Decidual cells are also in...

journal_title：Journal of molecular endocrinology

authors： Duval F,Dos Santos E,Moindjie H,Serazin V,Swierkowski-Blanchard N,Vialard F,Dieudonné MN

更新日期：2017-10-01 00:00:00

abstract：:The chemokine Stromal-derived factor-1alpha (SDF-1alpha) interacts with seven transmembrane (TM) G-protein-coupled receptor (GPR), CXCR4. SDF-1alpha is linked to inflammation, chemoattraction, cancer metastasis, and hematopoiesis. Tachykinin (Tac1) peptides bind seven transmembrane (TM), GPR and are involved in tumor ...

journal_title：Journal of molecular endocrinology

authors： Corcoran KE,Malhotra A,Molina CA,Rameshwar P

更新日期：2008-03-01 00:00:00

abstract：:A new full-length cDNA (ZFOR4) that encodes an opioid receptor has been isolated from the teleost zebrafish. The encoded polypeptide is 375 amino acids long and shows high sequence similarity to other delta-opioid receptors, including ZFOR1, the other delta-opioid receptor from zebrafish previously characterized by us...

journal_title：Journal of molecular endocrinology

authors： Pinal-Seoane N,Martin IR,Gonzalez-Nuñez V,Marron Fernandez de Velasco E,Alvarez FA,Sarmiento RG,Rodriguez RE

更新日期：2006-12-01 00:00:00

abstract：:In previous studies we demonstrated that IGF-I induces proliferation of pituitary lactotrophs. In addition to its mitotrophic actions, IGF-I is known to prevent apoptosis induced by diverse stimuli in several cell types. In this study, we investigated the action of IGF-I on pituitary cell survival and the intracellula...

journal_title：Journal of molecular endocrinology

authors： Fernández M,Sánchez-Franco F,Palacios N,Sánchez I,Fernández C,Cacicedo L

更新日期：2004-08-01 00:00:00

abstract：:The somatostatin (SRIF) system, which includes the SRIF ligand and receptors, regulates anterior pituitary gland function, mainly inhibiting hormone secretion and to some extent pituitary tumor cell growth. SRIF-14 via its cognate G-protein-coupled receptors (subtypes 1-5) activates multiple cellular signaling pathway...

journal_title：Journal of molecular endocrinology

authors： Eigler T,Ben-Shlomo A

更新日期：2014-08-01 00:00:00

abstract：:In vitro studies have indicated that the maturation-inducing hormone 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-DP, DHP), probably through nuclear progestin receptor (Pgr), might be involved in the proliferation of spermatogonial cells and the initiation of meiosis in several fish species. However, further in vivo evi...

journal_title：Journal of molecular endocrinology

authors： Liu G,Luo F,Song Q,Wu L,Qiu Y,Shi H,Wang D,Zhou L

更新日期：2014-08-01 00:00:00

abstract：:In the common brushtail possum (Trichosurus vulpecula) lactation lasts for 200 days and consists of two distinct phases. Milk composition changes dramatically between phase 2 and 3, which correspond to early and late lactation respectively (phase 1 corresponds to pregnancy). RNA expression patterns have been establish...

journal_title：Journal of molecular endocrinology

authors： Demmer J,Ross IK,Ginger MR,Piotte CK,Grigor MR

更新日期：1998-02-01 00:00:00