Abstract:
:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a novel member of the secretin/glucagon/vasoactive intestinal peptide (VIP) superfamily. In vertebrates, including avians, it occurs in two forms: PACAP(38) and PACAP(27). PACAP structure is well conserved during evolution, being identical in mammals, and showing one amino acid dfifference in avians (chick, turkey). PACAP is widely distributed in the central nervous system and peripheral tissues and displays a pleiotropic activity, including functions as a hypophysiotropic hormone, neuromodulator, and neurotrophic factor. PACAP exerts its biological actions through three types of receptors designated PAC(1), VPAC(1) and VPAC(1). This review (1) presents the current knowledge on PACAP origin, distribution and function, (2) compares the avian findings with those found in mammals, and (3) describes receptor-linked mechanisms in avians, including recent data on receptor-related signal transduction pathways, with a special emphasis on receptor pharmacology and function.
journal_name
Curr Pharm Desjournal_title
Current pharmaceutical designauthors
Nowak JZ,Zawilska JBdoi
10.2174/1381612033391586subject
Has Abstractpub_date
2003-01-01 00:00:00pages
467-81issue
6eissn
1381-6128issn
1873-4286journal_volume
9pub_type
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journal_title:Current pharmaceutical design
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abstract:: ...
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