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Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells.

Abstract：

:gamma-Synuclein is a small cytoplasmic protein implicated in neurodegenerative diseases and cancer. However, the mechanism of its involvement in diseases is not clear. We studied the role of gamma-synuclein in the regulation of matrix metalloproteinases in retinoblastoma cell culture. Matrix metalloproteinases play important roles in the remodeling of extracellular matrix implicated in tumor progression and in the neurodegenerative diseases. Western blot and zymography data demonstrated a moderate elevation of matrix metalloproteinases-2 and significant upregulation of matrix metalloproteinases-9 in stable cell lines overexpressing gamma-synuclein. No effect of gamma-synuclein overexpression on matrix metalloproteinases-1 level or activity was found. Chloramphenicol-acetyltransferase assay demonstrated that overexpression of gamma-synuclein increases the efficiency of the matrix metalloproteinases-9 promoter. This increment of promoter activity may be mediated by the AP-1 binding site(s), since point mutations in one of these sites (Pr18 or Pr19) and elimination of the distal AP-1 site (Pr14) reduced the increment of promoter activity.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Surgucheva IG,Sivak JM,Fini ME,Palazzo RE,Surguchov AP

doi

10.1016/s0003-9861(02)00664-1

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

167-76

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003986102006641

journal_volume

410

pub_type

杂志文章

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