Abstract:
:We aimed to provide a quantitative description of decay in pertussis antibody levels to aid in finding a serological estimate of the incidence of pertussis. The serum IgG response against pertussis toxin was studied in a group of clinically diagnosed patients. Individual records consisted of repeated serum IgG measurements at irregular intervals for up to 10 years post diagnosis. These data were analysed with a nonlinear regression model taking into account censoring at upper and lower threshold levels, measurement errors, and individual variation in the shape and magnitude of the immune response. There was considerable variation between individual responses, both in strength (amplitude) and duration (shape). The inverse model relating IgG levels to time from infection (diagnosis) can be applied to cross-sectional IgG data to generate distributions of times from infection, which may be used to calculate infection rates and their variation, in populations sampled for cross-sectional IgG data.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Teunis PF,van der Heijden OG,de Melker HE,Schellekens JF,Versteegh FG,Kretzschmar MEdoi
10.1017/s0950268802007896subject
Has Abstractpub_date
2002-12-01 00:00:00pages
479-89issue
3eissn
0950-2688issn
1469-4409journal_volume
129pub_type
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