Estrogen-androgen levels in aging men and women: therapeutic considerations.


:The influence of aging on serum levels of gonadotropins (FSH and LH), testosterone and estradiol was studied in the following groups: 4 normal men (ages 30 to 50), 38 men with symptoms of the male climacteric (ages 51 to 84), 25 men with relative impotence (ages 31 to 50), 10 normal women (ages 24 to 31), and 6 menopausal women (ages 58 to 76). FSH and LH levels began to rise in men in their 40's, and the increase became more conspicuous in the later age decades. The degree of elevation was nowhere comparable to that observed in the aging women. In the male, the serum testosterone levels showed a progressive decrease from the fifth age decade onward, whereas in the female there was an increase after the menopause. Estradiol levels showed no significant change in the aged male, but they were somewhat higher than in the aged female. Exceptions to the low-testosterone and low-gonadotropin relationship were observed in individual cases and might be explained by relatively high estradiol values. Proper replacement therapy by means of estrogens for the postmenopausal female and androgens for the aging male is often of great benefit, physically and emotionally.


J Am Geriatr Soc


Greenblatt RB,Oettinger M,Bohler CS




Has Abstract


1976-04-01 00:00:00












  • The use of quality-of-life considerations in medical decision making.

    abstract::Quality-of-life considerations in physicians' decisions on life-sustaining therapy were explored using a patient management problem (PMP) depicting acute respiratory failure in an elderly man with chronic pulmonary disease; 205 internal medicine and family medicine physicians were interviewed. The physicians' percepti...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Pearlman RA,Jonsen A

    更新日期:1985-05-01 00:00:00

  • Differences in the signs and symptoms of hyperthyroidism in older and younger patients.

    abstract:OBJECTIVES:To determine if aging modifies the clinical presentation of hyperthyroidism and the signs of thyrotoxicosis in older people. DESIGN:Prospective cohort study. SETTING:A French university hospital. SUBJECTS:Eighty-four new patients with overt hyperthyroidism confirmed chemically between January 1992 and Jan...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Trivalle C,Doucet J,Chassagne P,Landrin I,Kadri N,Menard JF,Bercoff E

    更新日期:1996-01-01 00:00:00

  • National Prescribing Trends for High-Risk Anticholinergic Medications in Older Adults.

    abstract:OBJECTIVES:To estimate prescribing tends of and correlates independently associated with high-risk anticholinergic prescriptions in adults aged 65 and older in office-based outpatient visits. DESIGN:Repeated cross-sectional analysis. SETTING:National Ambulatory Medical Care Survey (NAMCS). PARTICIPANTS:A national sa...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Rhee TG,Choi YC,Ouellet GM,Ross JS

    更新日期:2018-07-01 00:00:00

  • Effects of a Safe Transportation Educational Program for Older Drivers on Driving Exposure and Community Participation: A Randomized Controlled Trial.

    abstract:OBJECTIVES:To ascertain whether a safe-transportation program can change driving exposure while maintaining community participation of older drivers. DESIGN:Randomized controlled trial. SETTING:Northwest Sydney. PARTICIPANTS:Drivers aged 75 and older (mean 80 ± 4) (n = 380). INTERVENTION:Intervention group particip...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验


    authors: Coxon K,Chevalier A,Brown J,Clarke E,Billot L,Boufous S,Ivers R,Keay L

    更新日期:2017-03-01 00:00:00

  • Effect of medical conditions on improvement in self-reported and observed functional performance of elders.

    abstract:OBJECTIVES:To evaluate the effect of nine disabling medical conditions upon recovery from functional limitations by elders. DESIGN:Retrospective analysis of prospective longitudinal cohort. SETTING:Community. PARTICIPANTS:Persons aged 65 and older in Framingham Heart Study. MEASUREMENTS:Change in function in elders...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Miller RR,Zhang Y,Silliman RA,Hayes MK,Leveille SG,Murabito JM,Kiel D,O'Connor GT,Felson DT

    更新日期:2004-02-01 00:00:00

  • Hearing impairment as a determinant of function in the elderly.

    abstract::This clinical, practice-based study explores the research question: Is there a relationship between hearing loss and functional disturbance in elderly patients? We analyzed the impact of hearing impairment on 153 patients over 65 years of age screened in primary care practice. Functional and psychosocial impairment we...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Bess FH,Lichtenstein MJ,Logan SA,Burger MC,Nelson E

    更新日期:1989-02-01 00:00:00

  • The renal effects of nonsteroidal anti-inflammatory drugs in older people: findings from the Established Populations for Epidemiologic Studies of the Elderly.

    abstract:OBJECTIVE:To determine whether older people who use nonsteroidal anti-inflammatory agents (NSAIDs) have increased levels of blood urea nitrogen (BUN), serum creatinine, and BUN:serum creatinine ratio. DESIGN:Cross-sectional, secondary data analysis. SETTING:Older people living in the communities of East Boston, MA, N...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Field TS,Gurwitz JH,Glynn RJ,Salive ME,Gaziano JM,Taylor JO,Hennekens CH

    更新日期:1999-05-01 00:00:00

  • Effect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trial.

    abstract:OBJECTIVES:To investigate the effect of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) supplementation on quality of life (QOL). DESIGN:Randomized, double-blind, placebo-controlled trial. SETTING:Independently living individuals from the general older Dutch population. PARTICIPANTS:Three hundred two ind...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验


    authors: van de Rest O,Geleijnse JM,Kok FJ,van Staveren WA,Olderikkert MG,Beekman AT,de Groot LC

    更新日期:2009-08-01 00:00:00

  • Firearm presence in households of patients with Alzheimer's disease and related dementias.

    abstract:OBJECTIVE:Attention has recently been drawn to the potential dangers of firearm use among patients with dementia. However, little is known about the actual prevalence of firearms in households with demented family members. This study seeks to determine the prevalence and loaded status of firearms in households with a d...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Spangenberg KB,Wagner MT,Hendrix S,Bachman DL

    更新日期:1999-10-01 00:00:00

  • Motor profile and drug treatment of nursing home residents with Parkinson's disease.

    abstract:OBJECTIVES:To examine the clinical characteristics, motor impairments, and drug treatments of nursing home residents with Parkinson's disease (PD). DESIGN:Cross-sectional study. SETTING:Nursing homes in the southeast of the Netherlands. PARTICIPANTS:Nursing home residents with PD and a Mini-Mental State Examination ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Weerkamp NJ,Zuidema SU,Tissingh G,Poels PJ,Munneke M,Koopmans RT,Bloem BR

    更新日期:2012-12-01 00:00:00

  • Alcohol use, comorbidity, and mortality.

    abstract:OBJECTIVES:To examine the combined influence of alcohol use and comorbidity on 20-year mortality in older adults (average age 66 at the time of the baseline survey). DESIGN:Longitudinal analysis of a national probability sample-based cohort study. SETTING:Data sources were the National Health and Nutrition Examinatio...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Moore AA,Giuli L,Gould R,Hu P,Zhou K,Reuben D,Greendale G,Karlamangla A

    更新日期:2006-05-01 00:00:00

  • Community-acquired bacteremia in the elderly: analysis of one hundred consecutive episodes.

    abstract::A retrospective analysis was made of the records of 100 consecutive geriatric patients with community-acquired bacteremia, admitted to a suburban hospital. The most frequently identified tissue sources for these bacteremias were the urinary tract (34 percent), biliary tract (20 percent), and lungs (13 percent). In 11 ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Esposito AL,Gleckman RA,Cram S,Crowley M,McCabe F,Drapkin MS

    更新日期:1980-07-01 00:00:00

  • Rehabilitation Services Use of Older Adults According to Fall-Risk Screening Guidelines.

    abstract:OBJECTIVES:To characterize rehabilitation services use of older adults according to fall-risk classification based on screening guidelines. DESIGN:Cross-sectional analysis of 2015 National Health and Aging Trends Study. SETTING:Study participants' homes. PARTICIPANTS:National sample of 7,440 community-dwelling Medic...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Gell NM,Patel KV

    更新日期:2019-01-01 00:00:00

  • Rationale and design of a multi-center randomized trial of comprehensive geriatric assessment consultation for hospitalized patients in an HMO.

    abstract:OBJECTIVE:To describe the evaluation of an interdisciplinary comprehensive geriatric assessment (CGA) consultation program for targeted hospitalized patients. DESIGN:Multi-center randomized clinical trial (RCT) at four hospitals where patients were randomly assigned to CGA consultation or usual care by the attending p...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Borok GM,Reuben DB,Zendle LJ,Ershoff DH,Wolde-Tsadik G,Rubenstein LZ,Ambrosini VL,Fishman LK,Beck JC

    更新日期:1994-05-01 00:00:00

  • The epidemiology of skin tears in the institutionalized elderly.

    abstract::While skin tears are a common occurrence in the institutionalized elderly population, nothing has been written about this problem. We retrospectively studied all incident reports during a 1-year period at a large, urban, long-term-care facility to identify residents with skin tears. The overall incidence of skin tears...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Malone ML,Rozario N,Gavinski M,Goodwin J

    更新日期:1991-06-01 00:00:00

  • Adiponectin isoforms in elderly patients with or without coronary artery disease.

    abstract:OBJECTIVES:To study the distribution of adiponectin isoforms in a group of very old patients. DESIGN:Cross-sectional. SETTING:Geriatric ambulatory clinic of the Department of Medicine at Policlinico "Tor Vergata." PARTICIPANTS:One hundred eight elderly adults (mean age 85.0+/-3.2) with or without a history of a prev...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Rizza S,Gigli F,Galli A,Micchelini B,Lauro D,Lauro R,Federici M

    更新日期:2010-04-01 00:00:00

  • Biomarkers for delirium--a review.

    abstract::To improve delirium recognition and care, numerous serum biomarkers have been investigated as potential tools for risk stratification, diagnosis, monitoring, and prognostication of delirium. The literature was reviewed, and no evidence was found to support the clinical use of any delirium biomarker, although certain b...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审


    authors: Khan BA,Zawahiri M,Campbell NL,Boustani MA

    更新日期:2011-11-01 00:00:00

  • Patterns of comorbidity in older adults with heart failure: the Cardiovascular Research Network PRESERVE study.

    abstract:OBJECTIVES:To examine whether the total burden of comorbidity and pattern of co-occurring conditions varies in individuals with heart failure (HF) with preserved left ventricular ejection fraction (LVEF) (HF-P) or HF with reduced LVEF (HF-R). DESIGN:Cross-sectional cohort study. SETTING:Four participating health plan...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 历史文章,杂志文章,多中心研究


    authors: Saczynski JS,Go AS,Magid DJ,Smith DH,McManus DD,Allen L,Ogarek J,Goldberg RJ,Gurwitz JH

    更新日期:2013-01-01 00:00:00

  • Papers prepared by the National Institute on Aging for the White House Conference on Aging (WHCoA). Injury in late life: II. Prevention.

    abstract::Contemporary, systematic approaches to injury prevention are presented as guides for considering needless death and disability of older people because of falls, burns, and vehicular crashes. Injury results from an unfavorable relationship between etiologic agent and host within a particular environment setting. Abnorm...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Hogue CC

    更新日期:1982-04-01 00:00:00

  • Drug prescribing for ambulatory patients 85 years of age and older.

    abstract::Drug prescribing for ambulatory patients greater than or equal to 85 years of age was studied using data from the 1980 National Ambulatory Medical Care Survey (NAMCS) on office visits to physicians. NAMCS is a survey by the US National Center for Health Statistics, which collected information on office visits and extr...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Knapp DA,Knapp DA,Wiser TH,Michocki RJ,Nuessle SJ,Knapp WK

    更新日期:1984-02-01 00:00:00

  • Is there an association between metabolic syndrome and cognitive function in very old adults? The Newcastle 85+ Study.

    abstract:OBJECTIVES:To determine, using data from the Newcastle 85+ Study, whether there is an association between modern diagnostic criteria for metabolic syndrome (MetS) and cognitive function in very old adults (≥85) and whether inflammation, physical activity, or diabetes mellitus status affects this association. DESIGN:Lo...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Harrison SL,Stephan BC,Siervo M,Granic A,Davies K,Wesnes KA,Kirkwood TB,Robinson L,Jagger C

    更新日期:2015-04-01 00:00:00

  • How the human brain responds to aging.

    abstract::The characteristic morphologic changes frequently observed in the brain of an old adult include a decrease in weight and volume, a change in the pattern of cerebral cortical convolutions, and an increase in ventricular size. Cell loss varies from region to region in the brain, and may be intensified in Alzheimer's dis...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审


    authors: Samorajski T

    更新日期:1976-01-01 00:00:00

  • Conceptual challenges and practical approaches to screening capacity for self-care and protection in vulnerable older adults.

    abstract::Identifying impairments in the capacity to make and execute decisions is critical to the assessment and remediation of elder self-neglect. Few capacity assessment tools are available for use outside of healthcare settings, and none have been validated in the context of elder self-neglect. Health and social services pr...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审


    authors: Naik AD,Teal CR,Pavlik VN,Dyer CB,McCullough LB

    更新日期:2008-11-01 00:00:00

  • Cost-Effectiveness of Pneumococcal Vaccination Policies and Uptake Programs in US Older Populations.

    abstract:BACKGROUND/OBJECTIVES:Recently revised vaccination recommendations for US adults, aged 65 years and older, include both 23-valent pneumococcal polysaccharide vaccine (PPSV23) and 13-valent pneumococcal conjugate vaccine (PCV13), with PCV13 now recommended for immunocompetent older people based on shared decision making...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Wateska AR,Nowalk MP,Lin CJ,Harrison LH,Schaffner W,Zimmerman RK,Smith KJ

    更新日期:2020-06-01 00:00:00

  • Are Obese Residents More Likely to Be Admitted to Nursing Homes That Have More Deficiencies in Care?

    abstract:OBJECTIVES:To determine whether obese older adults who qualify for nursing home (NH) placement are as likely as nonobese adults to be admitted to NHs that provide adequate quality of care. DESIGN:Retrospective study. SETTING:NHs in New York State. PARTICIPANTS:Individuals aged 65 and older newly admitted to a NH in ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Zhang N,Rodriguez-Monguio R,Barenberg A,Gurwitz J

    更新日期:2016-05-01 00:00:00

  • Retrospective Evaluation of a Restrictive Transfusion Strategy in Older Adults with Hip Fracture.

    abstract:OBJECTIVES:To compare the association between a restrictive transfusion strategy and cardiovascular complications during hospitalization for hip fracture with the association between a liberal transfusion strategy and cardiovascular complications, accounting for all transfusions from the emergency department to postacu...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Zerah L,Dourthe L,Cohen-Bittan J,Verny M,Raux M,Mézière A,Khiami F,Tourette C,Neri C,Le Manach Y,Riou B,Vallet H,Boddaert J

    更新日期:2018-07-01 00:00:00

  • A comparison by payor/provider type of the cost of dying among frail older adults.

    abstract:OBJECTIVE:To compare expenditures and healthcare service use between decedents (in their last year of life) and survivors, all of whom were frail older people, under three payor/provider types. DESIGN:In-home interviews were conducted by home care nurses at baseline and at 6-month intervals for an 18-month period. Uti...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Experton B,Ozminkowski RJ,Branch LG,Li Z

    更新日期:1996-09-01 00:00:00

  • Effect of Hospice Use on Costs of Care for Long-Stay Nursing Home Decedents.

    abstract:OBJECTIVES:To analyze the costs for long-stay (>90 days) nursing home (NH) decedents with and without hospice care. DESIGN:Retrospective cohort study using a 1999-2009 data set of linked Medicare and Medicaid claims and minimum data set (MDS) assessments. SETTING:Indiana NHs. PARTICIPANTS:Long-stay NH decedents (N =...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Unroe KT,Sachs GA,Dennis ME,Hickman SE,Stump TE,Tu W,Callahan CM

    更新日期:2016-04-01 00:00:00

  • Healthy young and old women differ in their trunk elevation and hip pivot motions when rising from supine to sitting.

    abstract:OBJECTIVE:To describe the differences between healthy young and older women in regards to trunk elevation and hip pivot motions when rising from a supine to a seated position. DESIGN:Cross-sectional comparison. SETTING:University laboratory. PARTICIPANTS:Two groups of healthy female volunteers: young adult female co...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Alexander NB,Fry-Welch DK,Marshall LM,Chung CC,Kowalski AM

    更新日期:1995-04-01 00:00:00

  • Circumstances and contributing causes of fall deaths among persons aged 65 and older: United States, 2010.

    abstract:OBJECTIVES:To determine whether the increasing fall death rate among people aged 65 and older is due in part to temporal changes in recording the underlying cause of death. DESIGN:Analyses of multiple cause of death data using the online Centers for Disease Control and Prevention Wide-ranging ON-line Data for Epidemio...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章


    authors: Stevens JA,Rudd RA

    更新日期:2014-03-01 00:00:00