Methodologic issues in collecting data from debilitated patients with cancer near the end of life.

Abstract:

PURPOSE/OBJECTIVES:To report the experience of a group of researchers who have had a year of experience in a clinical trial with homecare hospice patients. SAMPLE:150 hospice patients with cancer and their primary caregivers who were accrued to a National Cancer Institute-funded clinical trial focusing on quality of life. METHODS:The investigative team kept careful records of the numbers of patient/caregiver dyads accrued to the study and the reasons for nonaccrual as well as reasons for attrition. Data were analyzed using descriptive statistics. FINDINGS:During a nine-month period, the hospice admitted 2,517 patients; 75% had cancer and 95% had caregivers, making them eligible for the study. However, after further screening, only 19% were eligible for contact and only 5% finally were accrued to the study. For the 125 patient/caregiver dyads actually accrued to the study, baseline data were obtained on only 50% and evaluable follow-up data on only 50%. CONCLUSIONS:Accruing patients to clinical trials and retaining them when they are critically ill and near death are extraordinarily difficult tasks. The inability to recruit and retain subjects for clinical trials has implications for integrity of data, data analysis, success of the project, and the cost of conducting such projects in the future.

journal_name

Oncol Nurs Forum

journal_title

Oncology nursing forum

authors

McMillan SC,Weitzner MA

doi

10.1188/03.ONF.123-129

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

123-9

issue

1

eissn

0190-535X

issn

1538-0688

journal_volume

30

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Longman AJ,Braden CJ,Mishel MH

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  • Development and implementation of a risk assessment tool for chemotherapy-induced neutropenia.

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    authors: Griffith H,Miller I

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    authors: Ferrell BR,Dow KH,Leigh S,Ly J,Gulasekaram P

    更新日期:1995-07-01 00:00:00

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    更新日期:1997-04-01 00:00:00

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  • Body-Related Shame and Guilt Predict Physical Activity in Breast Cancer Survivors Over Time.

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    pub_type: 杂志文章

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    更新日期:1991-01-01 00:00:00

  • Chemotherapy-induced cognitive impairment in women with breast cancer: a critique of the literature.

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    pub_type: 杂志文章,评审

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    doi:

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