Effects of conjugated linoleic acid on anaphylaxis and allergic pruritus.

Abstract:

:The effects of conjugated linoleic acid (CLA) against anaphylaxis and allergic pruritus were investigated using a in vivo assay. Inhibitory effects of CLA were observed on the immediate (type 1) hypersensitivity reaction, with CLA significantly suppressing the decrease in blood pressure (BP) and blood flow (BF) induced by the hen egg-white lysozyme (HEL)-anaphylactic reaction in ddY mice. After oral administration, CLA showed antipruritic activity, with significant inhibition of scratching behavior induced by compound 48/80 (COM), a histamine-release agent. When painted onto the skin, CLA also inhibited COM, platelet-activating factor, and protease-induced scratching behavior, and COM-induced vasodilation of the skin. CLA offers promise as a drug for the treatment of allergic and inflammatory pruritus not only as an oral but also a topical agent. The present findings demonstrate that CLA can be effective for the prevention and treatment of allergic disease with severe pruritus.

journal_name

Biol Pharm Bull

authors

Ishiguro K,Oku H,Suitani A,Yamamoto Y

doi

10.1248/bpb.25.1655

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

1655-7

issue

12

eissn

0918-6158

issn

1347-5215

journal_volume

25

pub_type

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