The effects of hydroxyethyl starch solutions on thromboelastography in preoperative male patients.

Abstract:

BACKGROUND:Hydroxyethyl starches (HES) have been shown to decrease clot strength and to increase coagulation times assessed by thromboelastography (TEG). HES with minimal anticoagulant side-effects is beneficial for plasma volume expansion in the perioperative setting. A comparison of the in vivo effects of high, middle and low molecular weight HES solutions on TEG variables has not been performed so far. METHODS:Blood was obtained before and after intravenous infusion (10 ml kg-1) of either saline, HES 70/0.5/4 (molecular weight in kDa/degree of substitution/C2:C6 ratio), HES 130/0.4/9, HES 200/0.6/9.4, or HES 450/0.7/4.6 in 50 otherwise healthy patients. Thromboelastography was performed in 360 micro l of 1% celite activated citrated whole blood after recalcification. RESULTS:HES 450/0.7/4.6 prolonged reaction time indicating impairment of the plasmatic coagulation system. TEG parameters indicative for platelet function, including angle alpha, maximum amplitude and coagulation time, deteriorated after infusion of HES 450/0.7/4.6 and HES 70/0.5/4. HES 200/0.6/9.4 and HES 130/0.4/9 impaired platelet contribution to hemostasis only partially, decreasing two or one TEG platelet parameters, respectively. CONCLUSION:Infusion of HES 450/0.7/4.6 compromises TEG parameters more than the other solutions tested, whereas HES 130/0.4/9 has the smallest effect. Further outcome-related studies are needed in order to assess the clinical relevance of our findings.

authors

Felfernig M,Franz A,Bräunlich P,Fohringer C,Kozek-Langenecker SA

doi

10.1034/j.1399-6576.2003.470112.x

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

70-3

issue

1

eissn

0001-5172

issn

1399-6576

pii

aas470112

journal_volume

47

pub_type

临床试验,杂志文章,随机对照试验
  • Haemodynamic responses and prolongation of QT interval of ECG after suxamethonium-facilitated intubation during anaesthetic induction in children: a dose-related attenuation by alfentanil.

    abstract::The haemodynamic response to endotracheal intubation and changes in the QT interval of ECG during anaesthetic induction were studied in 68 healthy children (5.5 years). The children were pretreated double-blindly with either alfentanil 10 micrograms/kg (A10), 25 micrograms/kg (A25), 50 micrograms/kg (A50) or saline (c...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1991.tb03305.x

    authors: Lindgren L,Rautiainen P,Klemola UM,Saarnivaara L

    更新日期:1991-05-01 00:00:00

  • Potential anti-thrombotic effects of local anaesthetics due to their inhibition of platelet aggregation.

    abstract::The aim was to study the possible anti-aggregating effects of local anaesthetics on platelets stimulated by physiological doses of adenosine-diphosphate and collagen. Platelet-rich plasma was therefore incubated in an aggregometer with lidocaine, bupivacaine or tocainide in various concentrations and for different inc...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1985.tb02292.x

    authors: Borg T,Modig J

    更新日期:1985-10-01 00:00:00

  • Intraoperative MgSO4 infusion protects oxygenation and lung mechanics in COPD patients during general anesthesia. A randomized clinical trial.

    abstract:BACKGROUND:The purpose of this study was to examine the effects of an intraoperative MgSO4 infusion on arterial oxygenation and lung mechanics in patients with moderate COPD undergoing cancer larynx surgery under general anesthesia (GA). Our primary outcome was arterial oxygenation determined by the PaO2 and PaO2 /FiO2...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13684

    authors: Ahmed A,Sayed AH,Elkholy J,Elshal S,Badwy A,Abdelhamid B,Ollaek M

    更新日期:2020-11-01 00:00:00

  • Neuromuscular blockade induced by flunarizine alone and in combination with pancuronium, suxamethonium or neomycin: studies in isolated rat phrenic-hemidiaphragm preparations.

    abstract::The in vitro effects of flunarizine on indirectly- and directly-elicited contractions in rat phrenic-hemidiaphragm preparations were studied. The interactions of flunarizine with non-depolarizing and depolarizing neuromuscular blocking drugs (pancuronium and suxamethonium) and with an aminoglycoside antibiotic (neomyc...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1989.tb02971.x

    authors: del Pozo E,Baeyens JM

    更新日期:1989-10-01 00:00:00

  • Maternal and foetal effects of remifentanil for general anaesthesia in parturients undergoing caesarean section: a systematic review and meta-analysis.

    abstract:BACKGROUND:Remifentanil has been suggested for the induction of general anaesthesia for caesarean section. We aimed to define remifentanil effects on maternal stress response as well as neonatal effects. METHODS:Relevant articles were retrieved by a systematic literature search. Randomized, controlled trials comparing...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1399-6576.2012.02723.x

    authors: Heesen M,Klöhr S,Hofmann T,Rossaint R,Devroe S,Straube S,Van de Velde M

    更新日期:2013-01-01 00:00:00

  • Management of a giant intracranial aneurysm using surface-heparinized extracorporeal circulation and controlled deep hypothermic low flow perfusion. A case report.

    abstract::Extracorporeal circulation with controlled hypothermic low flow perfusion was introduced during the surgical treatment of a patient with a giant intracranial aneurysm of the anterior communicating artery. Heparin-coated equipment (Carmeda Bio-Active Surface; CBAS) was utilized, thus reducing the need for systemic hepa...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1993.tb03804.x

    authors: Jolin A,Edén E,Berggren H,Roos A,von Essen C,Stephensen H,Hedström A,Karlsson H,Lindholm-Fransson L,Ricksten SE

    更新日期:1993-11-01 00:00:00

  • Socioeconomic status and risk of intensive care unit admission with sepsis.

    abstract:BACKGROUND:A recent study showed higher risk of bacteremia among individuals with low socioeconomic status (SES). We hypothesized that patients with a low SES have a higher risk of intensive care unit (ICU) admission with sepsis compared to patients with higher SES. METHODS:This was a case-control study on patients wi...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13114

    authors: Storm L,Schnegelsberg A,Mackenhauer J,Andersen LW,Jessen MK,Kirkegaard H

    更新日期:2018-08-01 00:00:00

  • Postoperative pain relief by topical lidocaine in the surgical wound of hysterectomized patients.

    abstract:BACKGROUND:To improve postoperative analgesia, local anesthetics have been administered perioperatively as infiltration or as aerosol in the surgical area. A previous study showed good analgesic effects by topical lidocaine in the wound in minor extraabdominal surgery (herniorraphy), while the same treatment in minor l...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1996.tb04493.x

    authors: Sinclair R,Westlander G,Cassuto J,Hedner T

    更新日期:1996-05-01 00:00:00

  • Intravenous glucose-insulin-potassium during off-pump coronary artery bypass surgery does not reduce myocardial injury.

    abstract:BACKGROUND:This randomized, double-blind, placebo-controlled study was designed to determine whether an intra-operative, intravenous infusion of glucose-insulin-potassium (GIK) could be helpful in the prevention of myocardial ischemia and in the maintenance of intra-operative cardiac performance in patients undergoing ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2006.01115.x

    authors: Shim YH,Kweon TD,Lee JH,Nam SB,Kwak YL

    更新日期:2006-09-01 00:00:00

  • Dexamethasone for pain after outpatient shoulder surgery: a randomised, double-blind, placebo-controlled trial.

    abstract:BACKGROUND:Dexamethasone has analgesic properties when given intravenously before surgery, but the optimal dose has not been determined. We hypothesised that a dose of 40 mg dexamethasone would improve analgesia after outpatient shoulder surgery compared with 8 mg. METHODS:A randomised, double-blind, placebo-controlle...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.12333

    authors: Bjørnholdt KT,Mønsted PN,Søballe K,Nikolajsen L

    更新日期:2014-07-01 00:00:00

  • Effects of oral clonidine premedication and postoperative i.v. infusion on haemodynamic and adrenergic responses during recovery from anaesthesia.

    abstract::The effects of clonidine, a central alpha 2-adrenoreceptor agonist, on haemodynamic and catecholamine changes were assessed during emergence from anaesthesia, a period which is associated with increased sympathetic nervous discharge, hypertension and tachycardia. According to a double-blind randomized design, 32 patie...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1991.tb03241.x

    authors: Bernard JM,Bourréli B,Homméril JL,Pinaud M

    更新日期:1991-01-01 00:00:00

  • Haemodynamics and oxygen consumption in the dog during high epidural block with special reference to the splanchnic region.

    abstract::High epidural block (Th I-IV) with bupivacaine was carried out in 16 dogs. Mean arterial blood pressure decreased to 52% of control value owing to nearly equal decreases in systemic vascular resistance and cardiac output. Portal venous blood flow decreased from 25.8 +/- 8.6 to 16.7 +/- 7.2 ml/kg b.w. X min-1 following...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1983.tb01937.x

    authors: Greitz T,Andreen M,Irestedt L

    更新日期:1983-06-01 00:00:00

  • Comparison of fentanyl and halothane as supplement to nitrous-oxide-oxygen anaesthesia for coronary artery surgery.

    abstract::Twenty unselected patients suffering from incapacitating angina, in spite of medication with nitrates, beta-blockers and calcium antagonists, were studied before and during coronary artery bypass surgery. Fentanyl or halothane was randomly used in combination with nitrous oxide for maintenance of anaesthesia in order ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1985.tb02152.x

    authors: Fischerström A,Ohqvist G,Settergren G

    更新日期:1985-01-01 00:00:00

  • Mortality prediction models in the adult critically ill: A scoping review.

    abstract:BACKGROUND:Mortality prediction models are applied in the intensive care unit (ICU) to stratify patients into different risk categories and to facilitate benchmarking. To ensure that the correct prediction models are applied for these purposes, the best performing models must be identified. As a first step, we aimed to...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/aas.13527

    authors: Keuning BE,Kaufmann T,Wiersema R,Granholm A,Pettilä V,Møller MH,Christiansen CF,Castela Forte J,Snieder H,Keus F,Pleijhuis RG,van der Horst ICC,HEALICS consortium.

    更新日期:2020-04-01 00:00:00

  • Effects of combined helium pre/post-conditioning on the brain and heart in a rat resuscitation model.

    abstract:BACKGROUND:The noble gas helium induces cardio- and neuroprotection by pre- and post-conditioning. We investigated the effects of helium pre- and post-conditioning on the brain and heart in a rat resuscitation model. METHODS:After approval by the Animal Care Committee, 96 Wistar rats underwent cardiac arrest for 6 min...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13041

    authors: Aehling C,Weber NC,Zuurbier CJ,Preckel B,Galmbacher R,Stefan K,Hollmann MW,Popp E,Knapp J

    更新日期:2018-01-01 00:00:00

  • Haemodynamic responses to antagonism of pancuronium and alcuronium block.

    abstract::Using non-invasive methods, haemodynamic responses to antagonism of pancuronium (Pc) and alcuronium (Ac) block were compared in patients anaesthetized with thiopental-N2O-fentanyl and undergoing minor surgery. Neuromuscular block (90%) was maintained with Pc in 10 patients and Ac in 10 patients. After surgery, atropin...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1981.tb01594.x

    authors: Heinonen J,Salmenperä M,Takkunen O

    更新日期:1981-02-01 00:00:00

  • Atelectasis and pulmonary shunting during induction of general anaesthesia--can they be avoided?

    abstract:BACKGROUND:Gas exchange is regularly impaired during general anaesthesia with mechanical ventilation. A major cause of this disorder appears to be atelectasis and consequently pulmonary shunt. After re-expansion, atelectasis reappears very slowly if 30% oxygen in nitrogen is used, but much faster if 100% oxygen is used...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1996.tb04483.x

    authors: Rothen HU,Sporre B,Engberg G,Wegenius G,Reber A,Hedenstierna G

    更新日期:1996-05-01 00:00:00

  • Treatment of venous air embolism with papaverine.

    abstract::Two cases of venous air embolism are described. One case occurred in a 12-year-old girl operated for ureteroileo-cutaneostomy; the other case occurred in a 44-year-old patient who underwent a hemihepatectomy. The haemodynamic and pulmonary consequences were successfully treated with intravenous papaverine. ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1989.tb02902.x

    authors: de Lange JJ,Booij LH,Smelt WL

    更新日期:1989-04-01 00:00:00

  • Epidural ropivacaine and sufentanil and the perioperative stress response after a radical retropubic prostatectomy.

    abstract:BACKGROUND:The effects of an epidural opioid and a local anesthetic on the perioperative stress responses have not been fully investigated in elderly patients undergoing cancer surgery. We hypothesized that the stress response after a radical retropubic prostatectomy (RRP) would be attenuated by epidural ropivacaine an...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2010.02360.x

    authors: Hong JY,Yang SC,Yi J,Kil HK

    更新日期:2011-03-01 00:00:00

  • Sublingual premedication with brotizolam.

    abstract::This randomized, double-blind and double-dummy study was carried out in order to compare the perioperative sedation after premedication with either brotizolam 0.25-0.50 mg sublingually or diazepam 5-10 mg orally. Sixty-two patients aged 18-60 years scheduled for minor gynaecological surgery in general anaesthesia were...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1992.tb03560.x

    authors: Laub M,Espersen K,Ejlersen E,Krintel JJ

    更新日期:1992-11-01 00:00:00

  • Multicentre study of validity and interrater reliability of the modified Nursing Care Recording System (NCR11) for assessment of workload in the ICU.

    abstract:BACKGROUND:Reliable assessment of nursing workload is necessary for the quantitative approach to staffing of intensive care units. The Nursing Care Recording System (NCR11) scores both the nursing contribution to patient care and those related to medical procedures. The purpose of the present work was to compare NCR11 ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.0001-5172.2004.00397.x

    authors: Walther SM,Jonasson U,Karlsson S,Nordlund P,Johansson A,Mälstam J,south-Eastern Intensive Care Network Of Sweden.

    更新日期:2004-07-01 00:00:00

  • Changes in rapidly extracted auditory evoked potentials during tracheal intubation.

    abstract:BACKGROUND:One of the problems encountered in assessment of the hypnotic level during anesthesia is the extraction of a consistent and reliable measure online and close to real time. Hemodynamic parameters such as heart rate and blood pressure are not, at least with the traditional single parameter versus time presenta...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.2000.440614.x

    authors: Urhonen E,Jensen EW,Lund J

    更新日期:2000-07-01 00:00:00

  • Opioid use in cancer pain. Is a more liberal approach enhancing toxicity?

    abstract::The majority of cancer patients develop pain before death. This pain has been shown to be underdiagnosed and undertreated. Opioid use has increased in the past 20 years in both developing and developed countries. The changing pattern in opioid use has resulted in the emergence of neurotoxicity as a major side effect o...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-6576.1999.430910.x

    authors: Daeninck PJ,Bruera E

    更新日期:1999-10-01 00:00:00

  • Reduced expression of mannose-specific receptors on murine peripheral blood polymorphonuclear leukocytes following prolonged anaesthesia with different inhalation agents.

    abstract::Inhalation anaesthetic agents are known to depress phagocytic functions such as mobilization, attachment, chemotactic motility, engulfment and intracellular killing. Mannose-specific sugar receptors on the surface of leukocytes are involved in a series of phagocytosis-related activities. To investigate the effect of a...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1990.tb03087.x

    authors: Bardosi L,Bardosi A,Hendrys M,Gabius HJ

    更新日期:1990-05-01 00:00:00

  • Measurement of acceleration: a new method of monitoring neuromuscular function.

    abstract::A new method for monitoring neuromuscular function based on measurement of acceleration is presented. The rationale behind the method is Newton's second law, stating that the acceleration is directly proportional to the force. For measurement of acceleration, a piezo-electric ceramic wafer was used. When this piezo el...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1988.tb02686.x

    authors: Viby-Mogensen J,Jensen E,Werner M,Nielsen HK

    更新日期:1988-01-01 00:00:00

  • Influence of orientations of guidewire tip on the placement of subclavian venous catheters.

    abstract:BACKGROUND:The role of a J-type guidewire tip has been known to prevent vascular or cardiac wall damage. We hypothesized that the course of the guidewire may be influenced by the initial orientations of the J-type guidewire tip during the subclavian approach. The purpose of this study was to investigate the influence o...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00758.x

    authors: Park HP,Jeon Y,Hwang JW,Han SH,Bahk JH,Oh YS

    更新日期:2005-11-01 00:00:00

  • Ultrasound-guided peripheral nerve blocks: what are the benefits?

    abstract:BACKGROUND:Use of ultrasound by anaesthesiologists performing regional blocks is rapidly gaining popularity. The aims of this review were to summarize and update accumulating evidence on ultrasound-guided nerve blocks, with an emphasis on the clinical relevance of the results and to critically appraise changing standar...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-6576.2008.01666.x

    authors: Koscielniak-Nielsen ZJ

    更新日期:2008-07-01 00:00:00

  • Four years' treatment with ketamine and a trial of dextromethorphan in a patient with severe post-herpetic neuralgia.

    abstract::N-methyl-D-aspartate (NMDA) receptors are involved in the development of neuropathic pain. Ketamine, a non-competitive NMDA receptor antagonist, has in several case reports given pain relief but efficacy in dosages tolerated in long-term ketamine treatment is unknown. Another substance with an antagonist action at NMD...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04709.x

    authors: Klepstad P,Borchgrevink PC

    更新日期:1997-03-01 00:00:00

  • Comparison of the effect of ketamine added to bupivacaine and ropivacaine, on stress hormone levels and the duration of caudal analgesia.

    abstract:BACKGROUND:The aim of this study was to compare bupivacaine 0.25% and ropivacaine 0.2%, singly and in combination with ketamine, for caudal administration in children. Duration of analgesia, the need for other analgesics and the stress response were measured. METHODS:Eighty children were randomized into four groups of...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00806.x

    authors: Akbas M,Titiz TA,Ertugrul F,Akbas H,Melikoglu M

    更新日期:2005-11-01 00:00:00

  • Fourier analysis of effects of varying pressure waveforms in electrical lung analogs.

    abstract::Six voltage waveforms were devised to simulate pressure curves of varying configuration for use in artificial ventilation. These waveforms were subjected to Fourier analysis and terms of the resulting series applied to a simple two-branch resistive-capacitive circuit intended to represent a lung analog using computer ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1984.tb02036.x

    authors: Bergman NA

    更新日期:1984-04-01 00:00:00