Abstract：
STUDY DESIGN:In vitro studies using isolated guinea pig spinal cord. OBJECTIVES:To develop an alternative model using isolated guinea pig spinal cord, which can be used to screen antioxidants for in vivo SCI treatment. SETTING:Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana, USA. METHODS:The compression injury was induced by a constant-displacement of 5-s compression of spinal cord using a modified forceps possessing a spacer. Reactive oxygen species (ROS) were evaluated using three distinct methods: fluorescence microscopy, lipid peroxidation assay, and flow cytometry. RESULTS:The injury-mediated ROS increases are comparable with other in vivo studies and consistent with our previous observation using a similar injury model and measured with electrophysiological and anatomical technique. Further, ascorbic acid, hypothermia, or the combination of both significantly suppressed superoxide and lipid peroxidation. The combination treatment was the most effective when compared with ascorbic acid or hypothermia alone. CONCLUSION:This in vitro model has the advantage of replicating some of the in vivo conditions while gaining the ability to control the experimental conditions. This in vitro model is suitable to study the mechanisms of ROS generation and degradation and can also be used to critically evaluate the effective suppressor of ROS in the contents of spinal cord traumatic injury.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Luo J,Li N,Robinson JP,Shi Rdoi
10.1038/sj.sc.3101363subject
Has Abstractpub_date
2002-12-01 00:00:00pages
656-65issue
12eissn
1362-4393issn
1476-5624journal_volume
40pub_type
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