Percutaneous stone implantation in the pig kidney: a new animal model for lithotripsy research.

Abstract:

PURPOSE:This report describes a new animal model for research on the parameters of shockwave delivery and the mechanisms of shockwave action in SWL. MATERIALS AND METHODS:Female pigs (approximately 45 kg) were anesthetized for creation of an upper pole peripheral caliceal access. The tract was dilated with a 30F Nephromax balloon and Amplatz sheath, and a 24F rigid nephroscope was used to guide a gypsum artificial stone into a lower pole calix. An internal ureteral stent was then placed. After a 2-hour recovery period, lithotripsy was performed using an unmodified Dornier HM3 lithotripter. Following SWL, en bloc excision of the urinary tract was performed, and the stone fragments were collected. RESULTS:As observed by nephroscopy, most stones were surrounded by urine that was free of clot or debris. Urine output was >1 mL/kg per minute by the time the animal was positioned for SWL after a 2-hour observation period. When the conditions of shockwave (SW) exposure were 400 SWs, 20 kV, and 120 SW/min, the efficiency of stone fragment recovery was 85% +/- 2% (N = 6 stones). CONCLUSIONS:This procedure provides a minimally invasive method for placement of model stones of clinically relevant size within the pig kidney. Stone implantation is efficient and permits experiments to be conducted in 1 day. Stone fragmentation can be quantitated, and the animal can serve as its own control. Long-term experiments are also feasible. Overall, this new animal model is appropriate for experimentation on the parameters of SW delivery in SWL.

journal_name

J Endourol

journal_title

Journal of endourology

authors

Paterson RF,Lingeman JE,Evan AP,Connors BA,Williams JC Jr,McAteer JA

doi

10.1089/089277902320913215

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

543-7

issue

8

eissn

0892-7790

issn

1557-900X

journal_volume

16

pub_type

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