Declines in switching underlie verbal fluency changes after unilateral pallidal surgery in Parkinson's disease.

Abstract:

:Declines in verbal fluency are consistently reported in patients with Parkinson's disease (PD) after pallidal surgery. In the present study, the clustering and switching components of semantic or category fluency (oral naming of items obtainable in supermarkets) were examined at baseline and four months after unilateral deep brain stimulation or pallidotomy in 45 patients with PD (30 left, 15 right pallidal surgery). Post-operative declines were observed for supermarket fluency total score and switching, but not for average cluster size. These findings support the proposal that semantic fluency decrements after pallidal surgery reflect a disruption of frontal-basal ganglia circuits mediating efficient shifting between semantic categories, or perhaps efficient access to categories, rather than a degradation of semantic stores.

journal_name

Brain Cogn

journal_title

Brain and cognition

authors

Tröster AI,Woods SP,Fields JA,Hanisch C,Beatty WW

doi

10.1016/s0278-2626(02)00504-3

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

207-17

issue

2

eissn

0278-2626

issn

1090-2147

pii

S0278262602005043

journal_volume

50

pub_type

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