Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans.

Abstract:

:Leptin may be a link in the relationship of obesity with hypertension. We evaluated associations of leptin with blood pressure (BP) in 54 normotensive and 114 hypertensive African American individuals. Plasma leptin was higher (P <.03) in hypertensive women than in normotensive women, although body mass index did not differ (30.5 +/- 0.5 v 30.2 +/- 0.8 kg/m(2)). After adjusting for obesity and insulin resistance, there were no significant relationships between leptin and BP; however, leptin independently predicted 28% of the variability of heart rate in hypertensive men (P <.01) and 18% of the variability of lithium clearance in hypertensive women (P <.01). Thus, in these obese hypertensive African American women, there is no direct or independent association of leptin with BP. However, leptin may contribute to hypertension in these women by increasing renal tubular sodium reabsorption.

journal_name

Am J Hypertens

authors

El-Gharbawy AH,Kotchen JM,Grim CE,Kaldunski M,Hoffmann RG,Pausova Z,Hamet P,Kotchen TA

doi

10.1016/s0895-7061(02)03089-3

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

989-93

issue

11

eissn

0895-7061

issn

1941-7225

pii

S0895706102030893

journal_volume

15

pub_type

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