Breaking free: "protein antibiotics" and phage lysis.

Abstract:

:Bacteriophages must destroy the bacterial cell wall to lyse their host and release their progeny into the environment. There are at least two distinct mechanisms by which phages destroy the cell wall. Bacteriophages with large genomes use a holin-endolysin system, while bacteriophages with small genomes encode a single lysis protein. Three unrelated single protein lysis systems are known and these proteins will be the focus of the review. Recent results indicate that at least two of these proteins inhibit cell wall synthesis and are thus the phage analogs of antibiotics like penicillin.

journal_name

Res Microbiol

journal_title

Research in microbiology

authors

Bernhardt TG,Wang IN,Struck DK,Young R

doi

10.1016/s0923-2508(02)01330-x

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

493-501

issue

8

eissn

0923-2508

issn

1769-7123

pii

S0923-2508(02)01330-X

journal_volume

153

pub_type

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