Sleep disturbance in mucopolysaccharidosis type III (Sanfilippo syndrome): a survey of managing clinicians.

Abstract:

:Sanfilippo syndrome (mucopolysaccharidosis type III) is the commonest mucoploysaccharidosis. It causes neurodegeneration with often profound sleep and behavioral disturbance. Management of the sleep disturbance is difficult and inconsistent. In this study, we surveyed clinicians with particular expertise in the management of individuals with mucopolysaccharidoses. We found that sleep problems are almost universal in this patient population and that no one treatment is consistently viewed as beneficial. Among the clinicians surveyed, melatonin is reported as the medication most likely to be of benefit. Benzodiazepines, chloral hydrate, antihistamines and antipsychotic agents are overall reported as less efficacious. The major side-effect of the medications as a group was reported to be daytime somnolence. Based on this study, recommendations are given regarding the approach to sleep disturbance in Sanfilippo syndrome.

journal_name

Clin Genet

journal_title

Clinical genetics

authors

Fraser J,Wraith JE,Delatycki MB

doi

10.1034/j.1399-0004.2002.620512.x

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

418-21

issue

5

eissn

0009-9163

issn

1399-0004

pii

cge620512

journal_volume

62

pub_type

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