Does the neurotransmitter transporter underlie adaptation at a histaminergic photoreceptor synapse?

Abstract:

:Using autoradiographic and biochemical techniques, we studied the sodium-dependent forward and reverse transport of the neurotransmitter histamine in an arthropod photoreceptor in order to test whether the transporter plays a central role in visual signal transfer at this synapse. In particular, we asked whether the histamine transporter might be the important factor in synaptic adaptation, the process by which the operating range of the synapse adapts to increasing depolarizations of the photoreceptor in increasing background light. Drugs known from electrophysiological observations to interfere with synaptic adaptation blocked the uptake of [3H]histamine into photoreceptors. These drugs also blocked the sodium (Na)-triggered efflux of [3H]histamine, previously loaded into photoreceptors, via the histamine transporter. Several lines of evidence showed that efflux of [3H]histamine did not occur via calcium-dependent exocytosis. First, efflux occurred when the preparation was bathed in calcium (Ca)-free/EGTA salines or in cobalt (Co)-containing salines. Even more importantly, efflux could be elicited from axons, whose membranes must contain the transporter protein since they take up [3H]histamine independently from the presynaptic terminals. Since both adaptation and the histamine transporter are blocked by the same agents, the transporter may underlie adaptation by maintaining the cleft histamine concentration in a particular range independent of light intensity. We also characterized the transporter further and found that it is partially dependent on chloride ions, and that neither [3H]norepinephrine nor [3H]dopamine are transported (at 20 microM), adding to evidence that the transporter is highly selective for histamine.

journal_name

Vis Neurosci

journal_title

Visual neuroscience

authors

Stuart AE,Gebhardt KA,Vogel SN,Rodriguez O

doi

10.1017/s0952523802193084

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

307-19

issue

3

eissn

0952-5238

issn

1469-8714

pii

S0952523802193084

journal_volume

19

pub_type

杂志文章
  • A neural and computational model for the chromatic control of accommodation.

    abstract::Accommodation is more accurate with polychromatic stimuli than with narrowband or monochromatic stimuli. The aim of this paper is to develop a computational model for how the visual system uses the extra information in polychromatic stimuli to increase the accuracy of accommodation responses. The proposed model is dev...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800000705

    authors: Flitcroft DI

    更新日期:1990-12-01 00:00:00

  • Eel visual pigments revisited: the fate of retinal cones during metamorphosis.

    abstract::During their complex life history, anguilliform eels go through a major metamorphosis when developing from a fresh water yellow eel into a deep-sea silver eel. In addition to major changes in body morphology, the visual system also adapts from a fresh water teleost duplex retina with rods and cones, to a specialized d...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080152

    authors: Bowmaker JK,Semo M,Hunt DM,Jeffery G

    更新日期:2008-05-01 00:00:00

  • Development of excitatory and inhibitory neurotransmitters in transitory cholinergic neurons, starburst amacrine cells, and GABAergic amacrine cells of rabbit retina, with implications for previsual and visual development of retinal ganglion cells.

    abstract::Starburst amacrine cells (SACs), the only acetylcholine (ACh)-releasing amacrine cells (ACs) in adult rabbit retina, contain GABA and are key elements in the retina's directionally selective (DS) mechanism. Unlike many other GABAergic ACs, they use glutamic acid decarboxlyase (GAD)(67), not GAD(65), to synthesize GABA...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523810000052

    authors: Famiglietti EV,Sundquist SJ

    更新日期:2010-03-01 00:00:00

  • Simulation of an anatomically defined local circuit: the cone-horizontal cell network in cat retina.

    abstract::The outer plexiform layer of the retina contains a neural circuit in which cone synaptic terminals are electrically coupled and release glutamate onto wide-field and narrow-field horizontal cells. These are also electrically coupled and feed back through a GABAergic synapse to cones. In cat this circuit's structure is...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800008440

    authors: Smith RG

    更新日期:1995-05-01 00:00:00

  • Contacts of dopaminergic interplexiform cells in the outer retina of the blue acara.

    abstract::Dopaminergic interplexiform cells in the retina of the blue acara were investigated using an antiserum against tyrosine hydroxylase and PAP visualization. In whole-mount preparations, we observed a homogeneous distribution of cell bodies throughout the retina without any indication of regional specialization. At the f...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800010737

    authors: Wagner HJ,Wulle I

    更新日期:1992-09-01 00:00:00

  • Fixational ocular motor control is plastic despite visual deprivation.

    abstract::The aim of this study was to assess the plasticity of human voluntary fixational eye movement control in relation to visual experience/chronic visual deprivation. Twelve blind adults participated (self-reported vision < or = light perception in each eye; age range = 23-56 years; visual experience range = 0-28 years; b...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523802194090

    authors: Hall EC,Ciuffreda KJ

    更新日期:2002-07-01 00:00:00

  • Space-time spectra of complex cell filters in the macaque monkey: a comparison of results obtained with pseudowhite noise and grating stimuli.

    abstract::White noise stimuli were used to estimate second-order kernels for complex cells in cortical area V1 of the macaque monkey, and drifting grating stimuli were presented to the sample of neurons to obtain orientation and spatial-frequency tuning curves. Using these data, we quantified how well second-order kernels predi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800003102

    authors: Gaska JP,Jacobson LD,Chen HW,Pollen DA

    更新日期:1994-07-01 00:00:00

  • Short-term effects of dopamine on photoreceptors, luminosity- and chromaticity-horizontal cells in the turtle retina.

    abstract::The effects of dopamine on luminosity-type horizontal cells have been documented in different vertebrate retinas, both in vivo and in vitro. Some of these effects may reflect direct action of dopamine onto these cells, but indirect effects mediated by presynaptic neurons cannot be ruled out. Furthermore, direct effect...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800008312

    authors: Ammermüller J,Weiler R,Perlman I

    更新日期:1995-05-01 00:00:00

  • A novel system for the classification of diseased retinal ganglion cells.

    abstract::Retinal ganglion cell (RGC) dendritic atrophy is an early feature of many forms of retinal degeneration, providing a challenge to RGC classification. The characterization of these changes is complicated by the possibility that selective labeling of any particular class can confound the estimation of dendritic remodeli...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523814000248

    authors: Tribble JR,Cross SD,Samsel PA,Sengpiel F,Morgan JE

    更新日期:2014-11-01 00:00:00

  • Distribution of GABA immunoreactivity in the cat retina: a light- and electron-microscopic study.

    abstract::The distribution of GABA-like immunoreactivity in the cat retina was studied through the use of preembedding immunocytochemistry for light microscopy and by postembedding immunogold techniques for electron microscopy. Staining was observed in both inner and outer plexiform layers. Approximately 30% of the somata in th...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800012323

    authors: Pourcho RG,Owczarzak MT

    更新日期:1989-01-01 00:00:00

  • Functional dopamine deficits in the senile rat retina.

    abstract::The activity of the endogenous retinal dopamine (DA) pathway has been examined in the pigmented rat using retinas obtained from normal adult (approximately 3 months) and senile adults (approximately 24 months) using an in vitro electrophysiological approach. By comparing the pharmacological sensitivity of the horizont...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800176035

    authors: Hankins MW

    更新日期:2000-11-01 00:00:00

  • Two opposite effects of ATP on the apparent sensitivity of the cGMP-gated channel of the carp retinal cone.

    abstract::Effects of ATP on the activity of cGMP-gated channels from carp cone photoreceptors were studied. In 29% of the patches examined (N = 45), ATP (1 mM) enhanced a current evoked by cGMP (20 microM, up to about 100%), in 33%. ATP suppressed it by up to about 90%, and in the remaining 38%, ATP had no effect. ATP showed si...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800012578

    authors: Watanabe S,Shen J

    更新日期:1997-07-01 00:00:00

  • Contrast processing by ON and OFF bipolar cells.

    abstract::Much of what is currently known about the visual response of retinal bipolar cells is based on studies of rod-dominant responses to flashes in the dark in the isolated retina. This minireview summarizes quantitative findings on contrast processing in the intact light-adapted retina based on intracellular recording fro...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审

    doi:10.1017/S0952523810000313

    authors: Burkhardt DA

    更新日期:2011-01-01 00:00:00

  • Cholera toxin mapping of retinal projections in pigeons (Columbia livia), with emphasis on retinohypothalamic connections.

    abstract::Anterograde transport of cholera toxin subunit B (CTb) was used to study the retinal projections in birds, with an emphasis on retinohypothalamic connections. Pigeons (Columbia livia) were deeply anesthetized and received unilateral intraocular injections of CTb. In addition to known contralateral retinorecipient regi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800002376

    authors: Shimizu T,Cox K,Karten HJ,Britto LR

    更新日期:1994-05-01 00:00:00

  • Alpha ganglion cells of the rabbit retina lose antagonistic surround responses under dark adaptation.

    abstract::Alpha ganglion cells from the midperiphery of the rabbit retina were recorded intracellularly under visual control, in a superfused everted eyecup, and labeled with HRP. Their physiology and large somata with broad dendritic arbors identified them as uniform populations of ON- and OFF-center alpha ganglion cells, whic...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800011512

    authors: Muller JF,Dacheux RF

    更新日期:1997-03-01 00:00:00

  • Neuropharmacological analysis of the role of indoleamine-accumulating amacrine cells in the rabbit retina.

    abstract::In order to elucidate the role of putative indoleaminergic amacrine cells in visual processing, we have employed pharmacological agents specific for the two classes of serotonin receptor, 5-HT2 and 5-HT1, which have been identified in both the retina and brain. Perfusion of the rabbit retina with 5-HT2 selective antag...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审

    doi:10.1017/s0952523800001930

    authors: Brunken WJ,Daw NW

    更新日期:1988-01-01 00:00:00

  • The interstitial nucleus of the superior fasciculus, posterior bundle (INSFp) in the guinea pig: another nucleus of the accessory optic system processing the vertical retinal slip signal.

    abstract::As in rabbit, gerbil, and rat, the guinea pig interstitial nucleus of the superior fasciculus, posterior bundle (INSFp) is a sparse assemblage of neurons scattered among the fibers forming the fasciculus bearing this name. Most of the INSFp neurons are small and are ovoid in shape. Interspersed among these, are a few ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800002182

    authors: Benassi C,Biral GP,Lui F,Porro CA,Corazza R

    更新日期:1989-01-01 00:00:00

  • The discoloration illusion.

    abstract::The discoloration illusion, a new visual phenomenon, is described. This phenomenon originates from the juxtaposition of eight chromatic parallel contours on a white background, creating a luminance gradient and enclosing a light red region. Under these conditions, the inner region appears white: the light red discolor...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523806233406

    authors: Pinna B

    更新日期:2006-05-01 00:00:00

  • Analysis of dendritic arbors of native and regenerated ganglion cells in the goldfish retina.

    abstract::The retinas of adult teleost fish can regenerate following injury, but little is known about the neuronal integration of the visual scene that is performed by the regenerated retina. Using goldfish retinal ganglion cells (RGCs) as the experimental system, an evaluation of dendritic arbor structure and passive electrot...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523899162060

    authors: Cameron DA,Vafai H,White JA

    更新日期:1999-03-01 00:00:00

  • Early development of eye and retina in lanternfish larvae.

    abstract::The morphological characteristics of the eyes and the retinae of lanternfish larvae of Lampanyctus crocodilus, Benthosema glaciale, and Myctophum punctatum were analyzed in pre-flexion, flexion, and post-flexion stages. Pre-flexion larvae of L. crocodilus, the species with the shallowest depth distribution, had spheri...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070484

    authors: Bozzano A,Pankhurst PM,Sabatés A

    更新日期:2007-05-01 00:00:00

  • Visual arrestin in Limulus is phosphorylated at multiple sites in the light and in the dark.

    abstract::Arrestins participate in the termination of phototransduction in both vertebrates and invertebrates. However, the visual arrestins of invertebrates and vertebrates differ significantly from one another in that the invertebrate visual arrestins become phosphorylated rapidly in response to light while those in the photo...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800175145

    authors: Battelle BA,Andrews AW,Kempler KE,Edwards SC,Smith WC

    更新日期:2000-09-01 00:00:00

  • Multifocal visual evoked potential responses to pattern-reversal, pattern-onset, pattern-offset, and sparse pulse stimuli.

    abstract::The purpose of the present study was to compare standard multifocal visual evoked potential (mfVEP) pattern-reversal responses with those produced by pattern-onset, pattern-offset, and pulsed pattern stimuli. mfVEP recordings were obtained from five normal subjects using VERIS and a 4-electrode array. The standard rev...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080954

    authors: Fortune B,Demirel S,Bui BV

    更新日期:2009-03-01 00:00:00

  • Neurotransmitters, receptors, and neuropeptides in the accessory optic system: an immunohistochemical survey in the pigeon (Columba livia).

    abstract::Immunohistochemical techniques were used to survey the distribution of several conventional transmitters, receptors, and neuropeptides in the pigeon nucleus of the basal optic root (nBOR), a component of the accessory optic system. Amongst the conventional neurotransmitters/modulators, the most intense labeling of fib...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800005964

    authors: Britto LR,Hamassaki DE,Keyser KT,Karten HJ

    更新日期:1989-11-01 00:00:00

  • Current source-density analysis of light-evoked field potentials in rabbit retina.

    abstract::The technique of current source-density analysis was applied to several components of the light-evoked field potentials (electroretinogram) from the retina of the superfused eyecup of rabbit. The depth distributions of the major current sources and sinks were: b-wave--sink at outer plexiform layer, source at inner ple...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523899162163

    authors: Karwoski CJ,Xu X

    更新日期:1999-03-01 00:00:00

  • Properties of stimulus-dependent synchrony in retinal ganglion cells.

    abstract::Neighboring retinal ganglion cells often spike synchronously, but the possible function and mechanism of this synchrony is unclear. Recently, the strength of the fast correlation between ON-OFF directionally selective cells of the rabbit retina was shown to be stimulus dependent. Here, we extend that study, investigat...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070757

    authors: Chatterjee S,Merwine DK,Amthor FR,Grzywacz NM

    更新日期:2007-11-01 00:00:00

  • Transitions between color categories mapped with a reverse Stroop task.

    abstract::In the reverse Stroop task, observers are instructed to ignore the ink color in which a color word is printed (the distractor color) and to respond to the meaning of the color word (the target). Reaction times (RTs) are faster with congruent combinations when the ink color matches the word than with incongruent combin...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523806233388

    authors: Smithson HE,Khan SS,Sharpe LT,Stockman A

    更新日期:2006-05-01 00:00:00

  • AMPA-selective glutamate receptor subunits GluR2 and GluR4 in the cat retina: an immunocytochemical study.

    abstract::AMPA-selective glutamate receptors play a major role in glutamatergic neurotransmission in the retina and are expressed in a variety of neuronal subpopulations. In the present study, immunocytochemical techniques were used to visualize the distribution of GluR2 and GluR4 subunits in the cat retina. Results were compar...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523899166100

    authors: Qin P,Pourcho RG

    更新日期:1999-11-01 00:00:00

  • Effect of early monocular enucleation upon ocular dominance columns and cytochrome oxidase activity in monkey and human visual cortex.

    abstract::We examined cytochrome oxidase (CO) activity in striate cortex of four macaque monkeys after monocular enucleation at ages 1, 1, 5, and 12 weeks. These animal experiments were performed to guide our interpretation of CO patterns in occipital lobe specimens obtained from two children who died several years after monocu...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523898152124

    authors: Horton JC,Hocking DR

    更新日期:1998-03-01 00:00:00

  • Temporal properties of surround suppression in cat primary visual cortex.

    abstract::The responses of neurons in primary visual cortex (V1) are suppressed by stimuli presented in the region surrounding the receptive field. There is debate as to whether this surround suppression is due to intracortical inhibition, is inherited from lateral geniculate nucleus (LGN), or is due to a combination of these f...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070563

    authors: Durand S,Freeman TC,Carandini M

    更新日期:2007-09-01 00:00:00

  • Projection status of calbindin- and parvalbumin-immunoreactive neurons in the superficial layers of the rat's superior colliculus.

    abstract::Immunocytochemistry and retrograde labeling were used to define the thalamic projections of calbindin- and parvalbumin-containing cells in superficial layers of the rat's superior colliculus (SC). Quantitative analysis revealed that 90.8 +/- 2.2% (mean +/- standard deviation) of the calbindin-immunoreactive neurons in...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380001141x

    authors: Lane RD,Allan DM,Bennett-Clarke CA,Howell DL,Rhoades RW

    更新日期:1997-03-01 00:00:00