Abstract：
:Two cases of primary primitive neuroectodermal tumors of the cervix are presented. The two female patients are 35 and 51 years of age who presented with abnormal uterine bleeding of several weeks' duration. On gynecologic examination, a mass in the cervical area was palpated and a biopsy was obtained. The initial biopsy was interpreted as possible small cell carcinoma in both women. A radical hysterectomy was performed in both patients. Grossly, in both cases, the uterine cervix showed an ill-defined tumor involving the ectocervix and endocervix, measuring 3.0 and 4.0 cm in greatest dimension, respectively, and showing areas of necrosis and hemorrhage. Histologic sections showed the presence of a malignant neoplasm arranged in cords and with a vague nesting pattern. Areas of hemorrhage and necrosis were also present. The neoplastic cells were characterized by having indistinct cell borders, small round to oval nuclei, and inconspicuous nucleoli. Mitotic figures were easily identified. In one patient, the tumor had metastasized to lymph nodes. Immunohistochemical studies revealed the neoplastic cells to be positive for antibodies for CD99 and focally for synaptophysin, while keratin, chromogranin, smooth muscle actin, desmin, and neurofilament protein were negative. Both patients received adjuvant chemotherapy and remain alive 5 and 18 months after initial diagnosis, respectively. The present cases highlight the importance of keeping primitive neuroectodermal tumors in the differential diagnosis of small cell neoplasms of the uterine cervix.
journal_name
Ann Diagn Patholjournal_title
Annals of diagnostic pathologyauthors
Malpica A,Moran CAdoi
10.1053/adpa.2002.35739subject
Has Abstractpub_date
2002-10-01 00:00:00pages
281-7issue
5eissn
1092-9134issn
1532-8198pii
S1092913402000230journal_volume
6pub_type
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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