Corneal endothelial cell protection during phacoemulsification: low- versus high-molecular-weight sodium hyaluronate.

Abstract:

PURPOSE:To compare the efficacy of low- and high-molecular-weight sodium hyaluronate in protecting corneal endothelial cells during phacoemulsification. SETTING:Miyata Eye Hospital, Miyakonojo, Miyazaki, Japan. METHODS:One hundred forty-nine eyes of 136 cataract patients were randomly assigned to have cataract surgery using sodium hyaluronate 1% with a low molecular weight (0.6 to 1.2 million d, Opegan) or sodium hyaluronate 1% with a high molecular weight (4 million d, Healon) during phacoemulsification. Each group was divided into 2 subgroups depending on the amount of ultrasound (% min) used during phacoemulsification, which was defined as the mean phacoemulsification energy (%) multiplied by phacoemulsification time (minutes). Corneal endothelial cell density was examined preoperatively and 3 months after surgery. The rate of cell loss was compared between the subgroups in the Opegan group and the Healon group. RESULTS:In the subgroups with ultrasound of 50% min or less, the mean rate of endothelial cell loss 3 months after surgery was 3.2% +/- 4.1% (SD) in the Opegan group and 5.9% +/- 5.3% in the Healon group (P =.0214). In the subgroups with ultrasound over 50% min, the mean rate of endothelial cell loss 3 months after surgery was 7.5% +/- 10.6% in the Opegan group and 14.8 +/- 9.0% in the Healon group (P =.0029). CONCLUSIONS:The results suggest that Opegan is more effective than Healon in protecting corneal endothelial cells during phacoemulsification regardless of the amount of ultrasound energy used.

authors

Miyata K,Maruoka S,Nakahara M,Otani S,Nejima R,Samejima T,Amano S

doi

10.1016/s0886-3350(02)01540-7

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

1557-60

issue

9

eissn

0886-3350

issn

1873-4502

pii

S0886335002015407

journal_volume

28

pub_type

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