Abstract:
:Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl). 183 references are cited.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Warren MJ,Raux E,Schubert HL,Escalante-Semerena JCdoi
10.1039/b108967fsubject
Has Abstractpub_date
2002-08-01 00:00:00pages
390-412issue
4eissn
0265-0568issn
1460-4752journal_volume
19pub_type
杂志文章,评审abstract::This review covers the morphology, isolation, total synthesis and biological activity of the naturally occurring alkaloids isolated from the Amaryllidaceae family, as well as the structurally related Sceletium alkaloids. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b316106b
更新日期:2005-02-01 00:00:00
abstract::Fungi have emerged worldwide as increasingly frequent causes of healthcare-associated infections, but fungal infections have generally been considered curable, and thus the demand for new antifungal agents has been very low. Although superficial fungal infections of the skin and nails are common and are for the most p...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b914961a
更新日期:2010-07-01 00:00:00
abstract::Covering: 2008 to 2016The total synthesis of natural products and their derivatives continues to inspire organic chemists to identify and test new synthetic strategies and develop and explore novel methodology. In recent years, visible light photoredox catalysis has risen to prominence as a powerful technology that en...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c6np00070c
更新日期:2016-10-26 00:00:00
abstract::2,5-Disubstituted tetrahydrofurans constitute the core skeleton of several natural products and are pivotal synthetic analogues of medicinal importance that exhibit remarkable bioactivities. Oxasqualenoid natural products are implicated as potent biologically active molecules, particularly with regard to demonstrating...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00029c
更新日期:2014-09-01 00:00:00
abstract::Covering: up to 2018 Ovothiols are sulfur-containing natural products biosynthesized by marine invertebrates, microalgae, and bacteria. These compounds are characterized by unique chemical properties suggestive of numerous cellular functions. For example, ovothiols may be cytoprotectants against oxidative stress, serv...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00045j
更新日期:2018-12-12 00:00:00
abstract::The article reviews the progress in the chemistry of the steroids that was published between January and December, 2001. The reactions and partial syntheses of estrogens, androgens, pregnanes, cholic acid derivatives, cholestanes and vitamin D analogues are covered. There are 184 references. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b212061p
更新日期:2003-06-01 00:00:00
abstract::Naturally-occurring nitro compounds display great structural diversity, and a wide range of biological activities. This review summarizes current information on the structures of naturally-occurring nitro compounds and on the biosynthesis of the nitro group. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c0np00024h
更新日期:2011-01-01 00:00:00
abstract::Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthetases (NRPSs) assem...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00022k
更新日期:2018-11-14 00:00:00
abstract::Covering: Early 2008 until the end of 2019Microorganisms which survive (extreme-tolerant) or even prefer (extremophilic) living at the limits of pH, temperature, salinity and pressure found on earth have proven to be a rich source of novel structures. In this update we summarise the wide variety of new molecules which...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/d0np00021c
更新日期:2020-07-16 00:00:00
abstract::Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b316419p
更新日期:2004-12-01 00:00:00
abstract::In this review the names, structures and occurrence of all new drimanes and rearranged drimanes which have been published between January 1990 and January 2003 have been collected. Subjects that have been treated are biosynthesis, analysis, biological activities, with special attention to cytotoxic activity and antife...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b311170a
更新日期:2004-08-01 00:00:00
abstract::Covering: up to the end of 2018 Piperazic acid is a cyclic hydrazine and a non-proteinogenic amino acid found in diverse non-ribosomal peptide (NRP) and hybrid NRP-polyketide (PK) structures. Piperazic acid was first identified as a residue in the monamycins in 1959. Since then, the piperazic acid residue has been fou...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00076j
更新日期:2019-12-11 00:00:00
abstract::Covering: up to 2017This review covers the biosynthetic and evolutionary aspects of lincosamide antibiotics, antitumour pyrrolobenzodiazepines (PBDs) and the quorum-sensing molecule hormaomycin. These structurally and functionally diverse groups of complex natural products all incorporate rarely occurring 4-alkyl-l-pr...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00047b
更新日期:2018-03-01 00:00:00
abstract::This Highlight describes factors that contribute to an ideal synthesis, including economies (step, time, atom, solvent, energy) and orientations (target, diversity, safety, function), and the role of synthesis-informed design directed at function in advancing synthesis and its impact on science. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00013g
更新日期:2014-04-01 00:00:00
abstract::Covering: up to September 2015. Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which we...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00090d
更新日期:2016-01-01 00:00:00
abstract::Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments o...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70128j
更新日期:2014-08-01 00:00:00
abstract::Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines. In this report, these three important classes of natural products are reviewed and classified on the basis of their oxygenation pattern. In ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b303648k
更新日期:2003-12-01 00:00:00
abstract::Covering: up to February 2019Actinomycetes are Gram positive bacteria of the phylum Actinobacteria. These organisms are one of the most important sources of structurally diverse, clinically used antibiotics and other valuable bioactive products, as well as biotechnologically relevant enzymes. Most strains were discove...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c9np00029a
更新日期:2019-09-01 00:00:00
abstract::The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide. It includes 349 metabolites and 150 references. The molecular phylogeny ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b807365a
更新日期:2008-10-01 00:00:00
abstract::This Highlight describes synthetic methods that have enabled new strategic approaches to the synthesis of natural product targets as well as libraries of compounds for unbiased screening experiments. The structural differences of the compounds produced by both efforts are illustrated. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b814468k
更新日期:2009-01-01 00:00:00
abstract::This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b103713g
更新日期:2002-02-01 00:00:00
abstract::Sesterterpenoids account for many bioactive natural products, often with unusual and complex structural features, which makes them attractive targets for synthetic chemists. This review surveys efforts undertaken toward the synthesis of sesterterpenoids, focusing on completed total syntheses and covering ca. 50 natura...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20005h
更新日期:2012-07-01 00:00:00
abstract::The diastereoselective addition of organometallic reagents to α-chloroaldehydes was first reported in 1959 and occupies a historically significant role as the prototypical reaction for Cornforth's model of stereoinduction. Despite clear synthetic potential for these reagents, difficulties associated with producing ena...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20108a
更新日期:2013-02-01 00:00:00
abstract::Covering: up to the end of 2015.Peptides are naturally occurring compounds that play an important role in all living systems and are responsible for a range of essential functions. Peptide receptors have been implicated in disease states such as oncology, metabolic disorders and cardiovascular disease. Therefore, natu...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00083a
更新日期:2016-06-02 00:00:00
abstract::This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b301028g
更新日期:2006-04-01 00:00:00
abstract::This review deals with the isolation and structure elucidation of meroterpenoids (natural products of mixed biosynthetic origin which are partially derived from terpenoids) from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate. It describes 333 fungal meroterpenoids a...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b820413f
更新日期:2009-08-01 00:00:00
abstract::This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to i...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b515619j
更新日期:2007-04-01 00:00:00
abstract::We compiled a data set of the compounds that terrestrial vertebrates (amniotes) use to send chemical signals, and searched for relationships between signal compound properties and signal function. Overall, relationships were scarce and formed only small-scale patterns. Terrestrial vertebrate signalling compounds are i...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00029g
更新日期:2015-07-01 00:00:00
abstract::This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthic invertebrates, fish and seabirds. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b702742g
更新日期:2008-08-01 00:00:00
abstract::This review covers the isolation, structure determination, synthesis, chemical transformations and biological activity of indolizidine and quinolizidine alkaloids. Included in the review are the hydroxylated indolizidines lentiginosine, swainsonine, castanospermine and their analogues; alkaloids from animal sources, i...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b612166g
更新日期:2008-02-01 00:00:00